The human umbilical cord stem cells improve the viability of OA degenerated chondrocytes

Wang, Hao; Xu, Yan; Jiang, Yuxin; Wang, Zheng; Li, Yufei; Shao, Qingdong

doi:10.3892/mmr.2018.8413

Cited by 27 publications

(30 citation statements)

References 47 publications

(46 reference statements)

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“…Another alternative for OA treatment with MSCs are human umbilical cord-derived MSCs (hUC-MSCs). These cells enhance the proliferation of OA chondrocytes and downregulate the expression of inflammatory cytokines, moreover, the co-culture of hUC-MSCs and OA chondrocytes may to be a therapeutic option for OA [ 22 ]. hUC-MSCs could be an alternative to BMMSCs for clinical applications, due to their easy preparation and low risk of viral contamination.…”

Section: Discussionmentioning

confidence: 99%

“…A study carried out in Shangai suggested that the secretion of hUC-MSCs enhanced chondrocyte proliferation and showed that these stem cells increased expression of chondrogenic genes ( aggrecan, sox-9, collagen II ), indicating chondrocytes promoted chondrogenic differentiation of hUC-MSCs, compared to the control group. They also postulated that hUC-MSCs inhibited inflammatory activity in OA chondrocytes [ 22 ]. In the same line, Zheng et al (2013) reported the chondrogenic differentiation of hUC-MSCs by co-culture with rabbit chondrocytes [ 95 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, an anti-aging effect of the conditioned medium of adipose-derived mesenchymal stem cells (ASCs) on OA chondrocytes has been reported, featured by downregulation of senescence markers induced by inflammatory stress [ 19 ]. Stem cells promote biological processes, such as vascularization, cell proliferation, differentiation, and modulation of the inflammatory process [ 20 ], and can be isolated, among others, from bone marrow, adipose tissue, umbilical cord blood, and placenta [ 21 , 22 ]. It is currently admitted that there are MSCs within the connective tissue of virtually all organs [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Adipose-Derived Mesenchymal Stem Cells: Are They a Good Therapeutic Strategy for Osteoarthritis?

Damia

Chicharro

López

et al. 2018

IJMS

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Osteoarthritis (OA) is a major cause of disability in elderly population around the world. More than one-third of people over 65 years old shows either clinical or radiological evidence of OA. There is no effective treatment for this degenerative disease, due to the limited capacity for spontaneous cartilage regeneration. Regarding the use of regenerative therapies, it has been reported that one option to restore degenerated cartilage are adipose-derived mesenchymal stem cells (ASCs). The purpose of this review is to describe and compare the efficacy of ASCs versus other therapies in OA. Methods: Recent studies have shown that ASCs exert paracrine effects protecting against degenerative changes in chondrocytes. According to the above, we have carried out a review of the literature using a combination of osteoarthritis, stem cells, and regenerative therapies as keywords. Results: Conventional pharmacological therapies for OA treatment are considered before the surgical option, however, they do not stop the progression of the disease. Moreover, total joint replacement is not recommended for patients under 55 years, and high tibia osteotomy (HTO) is a viable solution to address lower limb malalignment with concomitant OA, but some complications have been described. In recent years, the use of mesenchymal stem cells (MSCs) as a treatment strategy for OA is increasing considerably, thanks to their capacity to improve symptoms together with joint functionality and, therefore, the patients’ quality of life. Conclusions: ASC therapy has a positive effect on patients with OA, although there is limited evidence and little long-term follow-up.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Adipose-Derived Mesenchymal Stem Cells: Are They a Good Therapeutic Strategy for Osteoarthritis?

Damia

Chicharro

López

et al. 2018

IJMS

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“…Two articles reported the use of coculture systems combining HWJSC with human articular chondrocytes or osteoarthritis cells to allow these latter cell types to induce HWJSC differentiation. 41,42 The results suggested that coculture was able to promote chondrogenesis, and certain genes, including COL1A1, COMP, TGFb1, ACAN, and SOX9, were upregulated in differentiated HWJSC.…”

Section: Mesodermal Differentiation Potential Of Hwjscmentioning

confidence: 98%

Expanded Differentiation Capability of Human Wharton's Jelly Stem Cells Toward Pluripotency: A Systematic Review

Garzón

Chato‐Astrain

Campos

et al. 2020

Tissue Engineering Part B: Reviews

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Human Wharton's jelly stem cells (HWJSC) can be efficiently isolated from the umbilical cord, and numerous reports have demonstrated that these cells can differentiate into several cell lineages. This fact, coupled with the high proliferation potential of HWJSC, makes them a promising source of stem cells for use in tissue engineering and regenerative medicine. However, their real potentiality has not been established to date. In the present study, we carried out a systematic review to determine the multilineage differentiation potential of HWJSC. After a systematic literature search, we selected 32 publications focused on the differentiation potential of these cells. Analysis of these studies showed that HWJSC display expanded differentiation potential toward some cell types corresponding to all three embryonic cell layers (ectodermal, mesodermal, and endodermal), which is consistent with their constitutive expression of key pluripotency markers such as OCT4, SOX2, and NANOG, and the embryonic marker SSEA4. We conclude that HWJSC can be considered cells in an intermediate state between multipotentiality and pluripotentiality, since their proliferation capability is not unlimited and differentiation to all cell types has not been demonstrated thus far. These findings support the clinical use of HWJSC for the treatment of diseases affecting not only mesoderm-type tissues but also other cell lineages.

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“…Preliminary in vitro results on cocultures between wjMSCs and ILβ1-stimulated chondrocytes showed reduced expressions of cartilage-degrading enzymes, such as MMP-1 and MMP-3, as compared to ILβ1-stimulated chondrocytes alone [40]. The same decrease was observed also in OA chondrocytes after cocultures with wjMSCs [41]. Taken together, these results suggest a protective effect of wjMSCs on damaged chondrocytes and have been confirmed in vivo, whereby the injection of wjMSCs in rat models of OA showed reduced secretions of cartilage-degrading enzymes [42], inflammatory cytokines [43], increased cartilage matrix production and decreased chondrocyte apoptosis [44].…”

Section: Cord Blood and Wharton's Jelly Mscs For Oa And Ra Therapymentioning

confidence: 76%

Umbilical Cord MSCs and Their Secretome in the Therapy of Arthritic Diseases: A Research and Industrial Perspective

Arrigoni

D’Arrigo

Rossella³

et al. 2020

Cells

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The prevalence of arthritic diseases is increasing in developed countries, but effective treatments are currently lacking. The injection of mesenchymal stem cells (MSCs) represents a promising approach to counteract the degenerative and inflammatory environment characterizing those pathologies, such as osteoarthritis (OA). However, the majority of clinical approaches based on MSCs are used within an autologous paradigm, with important limitations. For this reason, allogeneic MSCs isolated from cord blood (cbMSCs) and Wharton’s jelly (wjMSCs) gained increasing interest, demonstrating promising results in this field. Moreover, recent evidences shows that MSCs beneficial effects can be related to their secretome rather than to the presence of cells themselves. Among the trophic factors secreted by MSCs, extracellular vesicles (EVs) are emerging as a promising candidate for the treatment of arthritic joints. In the present review, the application of umbilical cord MSCs and their secretome as innovative therapeutic approaches in the treatment of arthritic joints will be examined. With the prospective of routine clinical applications, umbilical cord MSCs and EVs will be discussed also within an industrial and regulatory perspective.

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The human umbilical cord stem cells improve the viability of OA degenerated chondrocytes

Cited by 27 publications

References 47 publications

Adipose-Derived Mesenchymal Stem Cells: Are They a Good Therapeutic Strategy for Osteoarthritis?

Adipose-Derived Mesenchymal Stem Cells: Are They a Good Therapeutic Strategy for Osteoarthritis?

Expanded Differentiation Capability of Human Wharton's Jelly Stem Cells Toward Pluripotency: A Systematic Review

Umbilical Cord MSCs and Their Secretome in the Therapy of Arthritic Diseases: A Research and Industrial Perspective

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