The Human Trypanosomiases

Weinman, David

doi:10.1016/b978-1-4832-2788-7.50009-7

Cited by 4 publications

(3 citation statements)

References 157 publications

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“…1970). It has been suggested as a possible vector of primate trypanosomiasis in Southeast Asia by Weinman (1968). Recently T. rubrofasciata has been cultured for experimental purposes in Malaysia (Cheong and Maria 1970) while in Singapore Zaman (1972) reports the use of a laboratory strain in trypanosome studies.…”

Section: Triatoma Rubrofasciata (De Geer)mentioning

confidence: 99%

“…It includes unconfirmed records of 2 species of Triatominae from Australia (Lent 1951). In the last few years there has been a focus of attention on possible trypanosomiasis in areas to the north of Australia and this has resulted in the confirmation of endemic primate trypanosomiasis in nearby Indonesia (Weinman 1968 ; Weinman and Wiratmadja 1969), as well as in Taiwan (Cross et a1 1968) and Malaysia (Weinman 1970). Since I now have a definite Australian record for the Triatominae it seems useful to record and illustrate this species, to comment on the earlier Australian records, and to summarize in English the literature on the Indo-Pacific species.…”

Section: Introductionmentioning

confidence: 99%

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Confirmation of the Presence of Triatominae (Hemiptera: Reduviidae) in Australia, With Notes on Indo‐pacific Species

Monteith

1974

Australian Journal of Entomology

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An annotated list is given of the Triatominae described from the Indo-Pacific region. Triatoma novaeguineae Miller, previously known only from New Guinea, is recorded from north Queensland, this being the first authentic record of Triatominae from Australia. Earlier Australian records of Triatoma migrans Breddin and T. amicitiae Lent are excluded and it is shown that the latter is actually from Ceylon.

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Section: Triatoma Rubrofasciata (De Geer)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Confirmation of the Presence of Triatominae (Hemiptera: Reduviidae) in Australia, With Notes on Indo‐pacific Species

Monteith

1974

Australian Journal of Entomology

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“…Few practical drugs have been developed for African human trypanosomiasis during the past decade. Present drugs are expensive, and their prolonged administration is difficult and often ineffectual, especially when the central nervous system is invaded (17,34). Metabolic pathways of pathogenic trypanosomes and of cancer cells seem similar in certain respects: both metabolize large amounts of glucose through the Embden-Meyerhof pathway, both need dehydrogenases to recycle NADH, andi both rely conspicuously on a-GP metabolism (5,13,24).…”

mentioning

confidence: 99%

Effects of Some Antitumor Agents on Growth and Glycolytic Enzymes of the Flagellate Crithidia

1969

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Some antitumor agents known to specifically inhibit certain tumor cell enzymes were examined for activity against glycolytic enzymes and growth of the insect trypanosomatid, Crithidia fasciculata. The cytoplasmic enzymes hexokinase, a-glycerophosphate dehydrogenase, malic dehydrogenase, and glucose-6-phosphate dehydrogenase were tested. Agaricic acid (2-hydroxy-1 ,2,3-nonadecane tricarboxylic acid) was highly inhibitory (50 to 100%) to malic and a-glycerophosphate dehydrogenases at 3 x 10-5 M; 2-(p-hydroxyphenyl)-2-phenylpropane (2 X 10-M), and 5,6-dichloro-2-benzoxazolinone (5 X 10-4 M) were less effective (50% inhibition) against them. The antiprotozoal agents primaquine (4 X 10-4 M) and Melarsoprol (8 X 10-4 M) were 30 to 40% inhibitory. Agaricic acid, 2-(p-hydroxyphenyl)-2-phenylpropane, and 5,6-dichloro-2-benzoxazolinone inhibited growth of Crithidia at less than 10-4 M. Eight other test compounds from the Cancer Chemotherapy National Service Center (CCNSC) were not toxic to cell growth, although two (4-biphenylcarboxylic acid and 1-[p-chlorobenzyl]-2-ethyl-5-methyl-indole-3acetic acid) inhibited Crithidia a-glycerophosphate dehydrogenase below 1 mM. All of the compounds used specifically inhibited cancer cell a-glycerophosphate dehydrogenase. The corresponding enzyme in pathogenic African trypanosomes is important in their terminal respiration. C. fasciculata may be useful in preliminary evaluation of chemotherapeutic agents as potential trypanocides. 11, 12) and arsenicals on glycolytic enzymes and cells of C. fasciculata. This trypanosomatid 23

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Susceptibility of an Insect Leptomonas and Crithidia fasciculata to Several Established Antitrypanosomatid Agents

Bacchi

Lambros

Goldberg

et al. 1974

Antimicrob Agents Chemother

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Growth inhibition of the lower trypanosomatids Crithidia fasciculata and a Leptomonas from a hemipteron by several established trypanocides and leishmanicides were compared in four complex and one defined media. The Leptomonas was more susceptible than C. fasciculata in all media, especially to phenanthridines (ethidium, prothidium, isometamidium) and diamidines (pentamidine, diminazene diaceturate [Berenil], hydroxystilbamidine, stilbamidine); concentrations of these drugs required for 50% inhibition of the Leptomonas were <5 μg/ml. In contrast, C. fasciculata was uninhibited by <20 μg of diamidines per ml and was three- to sixfold less susceptible than the Leptomonas to isometamidium and prothidium. Both trypanosomatids were susceptible to nucleoside antibiotics, e.g., nucleocidin. Neither was inhibited by suramin, melarsen, melarsen oxide, or tryparsamide. The Leptomonas was more susceptible to standard trypanocides than five other insect trypanosomatids in a complex medium; it was the only one inhibited by <20 μg of stilbamidine and hydroxystilbamidine per ml.

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The Human Trypanosomiases

Cited by 4 publications

References 157 publications

Confirmation of the Presence of Triatominae (Hemiptera: Reduviidae) in Australia, With Notes on Indo‐pacific Species

Confirmation of the Presence of Triatominae (Hemiptera: Reduviidae) in Australia, With Notes on Indo‐pacific Species

Effects of Some Antitumor Agents on Growth and Glycolytic Enzymes of the Flagellate Crithidia

Susceptibility of an Insect Leptomonas and Crithidia fasciculata to Several Established Antitrypanosomatid Agents

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