The human placenta – An alternative for studying foetal exposure

Myren, Maja; Mose, Tina; Mathiesen, Line; Knudsen, Lisbeth E.

doi:10.1016/j.tiv.2007.05.011

Cited by 148 publications

(92 citation statements)

References 75 publications

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“…Placenta contains some specific proteins, such as CYP1, CYP2, and CYP3, which could be largely responsible for the mechanisms in the detoxification of toxins in the placenta tissue. 21 In the present study, the boundary difference also implied the monodechlorinated metabolism of anti-DP was not negligible in the placenta. It appeared that to a certain extent the detoxify function of placenta likely could be contributable to the biotransformation of anti-DP in humans.…”

Section: ■ Results and Discussionmentioning

confidence: 44%

“…26 Placenta is rich with enzymatic machinery and is able to carry out both phase I and II reactions. 21 These unique biochemical processes in the placental tissues may be related to the occurrence of DP stereoselective bioaccumulation during the transfer of DP from maternal blood to cord blood. It appeared that the specific human compartments may strongly contribute to the stereoselective bioaccumulation of DP in humans.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Placental Transfer of Dechlorane Plus in Mother–Infant Pairs in an E-Waste Recycling Area (Wenling, China)

Ben

Yang

et al. 2014

Environ. Sci. Technol.

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It has been reported that breastfeeding can expose newborns to dechlorane plus (DP), but transplacental transfer of DP has not been documented. We measured DP and its dechlorinated analogs in matched maternal blood− placenta−cord blood samples from 72 residents of the e-waste recycling area of Wenling, China. DP was detected in cord sera, indicating the occurrence of prenatal DP exposure and the transfer of DP across the placenta. The concentration ratio in the cord serum and maternal serum was estimated to be 0.45 for syn-DP and 0.35 for anti-DP, indicating the placenta partially limited DP transfer with a greater extent for anti-DP. The DP concentrations in the maternal serum, placenta, and cord serum strongly correlated, indicating that DP could transfer between the tissues. The DP concentrations in the matched samples could be predicted from each other. The anti-DP/ total DP concentration ratios in the placentas and cord sera were significantly different from those in the maternal sera, suggesting that DP stereoselectively bioaccumulates in human tissues. When the congener concentrations of polybrominated diphenyl ethers (PBDEs) were used as control variables, DP and total triiodothyronine concentrations were associated in the sera from mothers who had lived in Wenling for over 20 years.

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Section: ■ Results and Discussionmentioning

confidence: 44%

Section: ■ Results and Discussionmentioning

confidence: 99%

Placental Transfer of Dechlorane Plus in Mother–Infant Pairs in an E-Waste Recycling Area (Wenling, China)

Ben

Yang

et al. 2014

Environ. Sci. Technol.

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“…One of the reasons is that the placenta does not completely protect the fetus from the outside influences (Vähäkangas and Myllynen 2006;Myren et al 2007). Factors that may increase fetal susceptibility include higher rates of cell proliferation, the greater number of target cells at risk, lower immunologic competence, and decreased capacity to activate and detoxify carcinogens as well as to repair DNA (Anderson et al 2000;Perera et al 2004;Whyatt et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Treatment of Pregnant Women with a Betamimetic and Verapamil Increases the Micronuclei Frequency in Umbilical Cord Blood Lymphocytes

Grujičić

Milošević-Djordjević

Arsenijevic

et al. 2008

Tohoku J. Exp. Med.

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In prevention of preterm labor, betamimetics are used in gynecological practice mostly combined with antiarrhythmic verapamil because of their therapeutic cardiovascular side effects. The aim of this study was to investigate the influence of a betamimetic (ritodrine hydrochloride, fenoterol or hexoprenaline) and verapamil (administered to mothers) on the frequency of micronuclei (MN) in umbilical cord blood lymphocytes of neonates, using cytokinesis-block micronucleus test. The analyzed sample included 23 babies whose mothers received the therapy and 30 control babies whose mothers received no therapy. The average MN frequency was significantly higher in the neonates whose mothers received the therapy (8.13 ± 2.69 MN/1000 BN cells), in comparison with the baseline frequency in untreated controls (3.30 ± 2.63 MN/1000 BN cells), with probability p < 0.05. The highest MN frequency was found in neonates whose mothers received fenoterol and verapamil (2.8-fold i.e. 9.10 ± 3.00 MN/1000 BN cells), while ritodrine hydrochloride and hexoprenaline combined with verapamil induced 2.3-fold and 2.2-fold higher MN values than in controls (7.50 ± 3.33 MN/1000 BN cells and 7.29 ± 0.95 MN/1000 BN cells). Multiple linear regression analysis showed that MN frequency was affected only by the maternal therapeutic treatment, while the neonates' sex, maternal age, cigarette smoking, and therapeutic doses did not affect the MN frequency in umbilical lymphocytes of neonates. We conclude that the treatment of pregnant women with a betamimetic and verapamil significantly increases the MN frequency in umbilical cord blood lymphocytes of neonates, regardless to therapeutic doses.umbilical cord blood lymphocytes; micronuclei; betamimetic; verapamil.Tohoku

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“…Before the disaster caused by the use of thalidomide in the late 1950s and early 1960s, placenta was considered a barrier capable of protecting the fetus from any pharmacological damage (Lenz, 1962;Martinez-Frias et al, 2012;Oliveira et al, 1999;Papaseita et al, 2013). However, currently it is known that most drugs, as well as various substances present in the environment have the ability to cross the placental barrier and reach the bloodstream of the fetus, exposing it to pharmacological and/or teratogenic effects (Berglund et al, 1984;Giaginis et al, 2012;Myren et al, 2007;Schantz, 1996;Swan, 2000;Tilson et al, 1998;West and Blake, 2005). Nonsteroidal anti-inflammatory drugs (NSAIDs), for example, widely prescribed in pregnancy to treat fever, pain and inflammation may cause embryo-fetal and neonatal adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of medication use among low risk pregnant women: A drug utilization study

Fontoura¹,

Ayres²,

Martins-Nagai³

et al. 2014

Afr. J. Pharm. Pharmacol.

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This study aimed to characterize the profile of medication consumption by low risk pregnant women and to correlate it with sociodemographic characteristics of this population. A cross-sectional descriptive study was conducted in the Reference Center of Women's Health in the Brazilian municipality of Ribeirão Preto. This study included women which were at least in the 32nd week of the gestation period. Data related to sociodemographic characteristics of the pregnant women and to their pregnancy and medication consumption were collected from June, 2008 to November, 2008. A total of 699 pregnant women were included. About 20% of the pregnant women began prenatal care in the 12th week of gestation and 75.3% had at least six antenatal visits. The use of at least one drug during pregnancy was reported by 98% of the participants. The mean number of medications used was 4.35. According to the Food and Drug Administration (FDA) risk classification, 14.07% of the medication belonged to C category, 1.85% to D and 0.03% to X, and 38.30% were not identified or not classified by the FDA. When correlating the number of prenatal visits with the amount of medication used, it was verified that pregnant women who underwent less than six visits during pregnancy used a higher number of medications. Pregnant women have been exposed to a variety of medications and there is a need to improve the quality of care in order to prevent potential risks to the fetus, especially in relation to the use of medications.

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The human placenta – An alternative for studying foetal exposure

Cited by 148 publications

References 75 publications

Placental Transfer of Dechlorane Plus in Mother–Infant Pairs in an E-Waste Recycling Area (Wenling, China)

Placental Transfer of Dechlorane Plus in Mother–Infant Pairs in an E-Waste Recycling Area (Wenling, China)

Treatment of Pregnant Women with a Betamimetic and Verapamil Increases the Micronuclei Frequency in Umbilical Cord Blood Lymphocytes

Prevalence of medication use among low risk pregnant women: A drug utilization study

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