The Human Obesity Gene Map: The 2001 Update

Rankinen, Tuomo; Pérusse, Louis; Weisnagel, S. John; Snyder, Eric E.; Chagnon, Yvon C.; Bouchard, Claude

doi:10.1038/oby.2002.30

Cited by 150 publications

(121 citation statements)

References 441 publications

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“…Linkage studies suggest that many distinct genetic loci contribute to the heritability of obesity. Currently, over 250 genes, markers, or chromosomal regions have been shown to be associated with human obesity, including mutations of genes encoding leptin, the leptin receptor, and the melanocortin 4 receptor (MC 4 R) (Rankinen et al 2002).…”

Section: Etiology Of Obesitymentioning

confidence: 99%

Relevance of animal models to human eating disorders and obesity

2008

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Background and rationale This review addresses the role animal models play in contributing to our knowledge about the eating disorders anorexia nervosa (AN) and bulimia nervosa (BN) and obesity. Objectives Explore the usefulness of animal models in complex biobehavioral familial conditions, such as AN, BN, and obesity, that involve interactions among genetic, physiologic, psychological, and cultural factors. Results and conclusionsThe most promising animal model to mimic AN is the activity-based anorexia rodent model leading to pathological weight loss. The paradigm incorporates reward elements of the drive for activity in the presence of an appetite and allows the use of genetically modified animals. For BN, the sham-feeding preparation in rodents equipped with a gastric fistula appears to be best suited to reproduce the postprandial emesis and the defects in satiety. Animal models that incorporate genes linked to behavior and mood may clarify biobehavioral processes underlying AN and BN. By contrast, a relative abundance of animal models has contributed to our understanding of human obesity. Both environmental and genetic determinants of obesity have been modeled in rodents. Here, we consider single gene mutant obesity models, along with models of obesigenic environmental conditions. The contributions of animal models to obesity research are illustrated by their utility for identifying genes linked to human obesity, for elucidating the pathways that regulate body weight and for the identification of potential therapeutic targets. The utility of these models may be further improved by exploring the impact of experimental manipulations on the behavioral determinants of energy balance.

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Section: Etiology Of Obesitymentioning

confidence: 99%

Relevance of animal models to human eating disorders and obesity

2008

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“…foi observado nos estudos da obesidade (RANKINEN et al, 2002). Além dessa aplicação, as microssatélites podem estar envolvidas diretamente na regulação de genes, como é o caso da HUMTH01, uma repetição do tetranucleotídeo TCAT, que está envolvida na regulação transcricional do gene da tirosina hidroxilase (ALBANESE et al, 2001).…”

Section: Discussionunclassified

“…Um grande número de Quantitative Trait Loci (QTL), mutações e polimorfismos já foram descritos, e quantidades crescentes de genes e marcadores, associados ou ligados ao fenótipo da obesidade, são relatados (RANKINEN et al, 2002;CHAGNON et al, 2002;OBESITY, 2004). No entanto, ainda não foi possível estabelecer os mecanismos pelos quais os genes influenciam no desenvolvimento da obesidade.…”

Section: Discussionunclassified

“…As bases genéticas da obesidade apontam para modelos de herança poligênica, que incluem alterações em genes de proteínas envolvidas diretamente na regulação da ingestão, armazenamento e gasto de energia (VILLARES, 1998;ARNER, 2000;RANKINEN et al, 2002), ou mesmo em outros genes relacionados a outros sistemas metabólicos, como o do receptor de LDL (MATTEVI, 2000;ARNER, 2000), e outros neuroreceptores (YUAN et al, 2000;ARNER, 2001;LEINEWEBER et al, 2004).…”

Section: Alterações Genéticas Que Podem Estar Associadas à Obesidadeunclassified

“…As SNP têm sido relacionadas a disfunções metabólicas, incluindo a obesidade, e variações na resposta à terapia farmacológica (TAYLOR et al, 2001;IRIZARRY et al, 2002;CHAGNON et al, 2003). (THOMSON, 2001;RANKINEN et al, 2002). …”

Section: Alterações Genéticas Que Podem Estar Associadas à Obesidadeunclassified

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