The human MyoD1 (MYF3) gene maps on the short arm of chromosome 11 but is not associated with the WAGR locus or the region for the Beckwith-Wiedemann syndrome

Gessler, Manfred; Hameister, Horst; Henry, Isabelle; Junien, Claudine; Braun, Thomas; Arnold, Hans Henning

doi:10.1007/bf00197694

Cited by 7 publications

(2 citation statements)

References 25 publications

(24 reference statements)

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“…MYOD1 was 100% concordant with UPK2, the marker for BTA 15 , while MYOG was 95% concordant with PIGR, the marker for BTA 16 (Kulseth et al 1992). MYOD1 has been previously assigned to HSA 11p14 (Gessler et al 1990) and mouse chromosome 11 (Tapscott et al 1988). MYOG has been mapped to HSA 1q31-41 and mouse chromosome 1 (Olson et al 1990).…”

Section: Resultsmentioning

confidence: 99%

Chromosomal assignment of six muscle‐specific genes in cattle

Ryan¹,

Schelling²,

Womack³

et al. 1997

Animal Genetics

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Six genes expressed in skeletal or smooth muscle were assigned to bovine chromosomes using rodent, human or bovine cDNA probes. Myogenic determination factor (MYOD1) was 100% concordant with Bos taurus chromosome (BTA) 15, and myogenin (MYOG) was 95% concordant with BTA 16. Smooth muscle caldesmon (CALD1) and the skeletal muscle chloride channel gene (CLCN1) were 100% concordant with BTA 4. Myogenic factor 5 (MYF5) was 90% concordant with BTA 5; this assignment was confirmed by fluorescence in situ hybridization of a bovine genomic MYF5 probe to BTA 5 band 13 and the homologous band on river buffalo 4q. In some metaphases, specific hybridization signals were also observed on BTA 15 band 23, and the equivalent river buffalo homologue, with the MYF5 genomic probe. Because MYOD1 and MYF5 share both nucleotide and functional homology and because MYOD1 was mapped in somatic cell hybrids to BTA 15, we suggest that MYOD1 may be located at BTA 15 band 23. Herculin/myogenic factor 6 (MYF6) was assigned indirectly to BTA 5 by the hybridization of MYF5 and MYF6 probes to the same HindIII fragment in bovine genomic DNA. The assignment of MYF6 to BTA 5 is consistent with the tandem arrangement of MYF5 and MYF6 in human, mouse and chicken, where these tightly linked genes are separated by < 6.5 kb of DNA.

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Section: Resultsmentioning

confidence: 99%

Chromosomal assignment of six muscle‐specific genes in cattle

Ryan¹,

Schelling²,

Womack³

et al. 1997

Animal Genetics

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“…WAGR syndrome (Wilms’ tumor, aniridia, genitourinary anomalies, mental retardation) [ 3 ] is associated with interstitial deletions in a region in chromosome 11p13 [ 4 , 5 ]. This locus contains several genes such as WT1 , BDNF [ 6 ], PAX6 [ 7 ] (all important during development), FSHB [ 8 ], RCN1 , and MPPED2 ( 239FB ) [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Neuronal expression in Drosophila of an evolutionarily conserved metallophosphodiesterase reveals pleiotropic roles in longevity and odorant response

Gupta,

Chakrabarti,

Janardan

et al. 2023

PLoS Genet

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Evolutionarily conserved genes often play critical roles in organismal physiology. Here, we describe multiple roles of a previously uncharacterized Class III metallophosphodiesterase in Drosophila, an ortholog of the MPPED1 and MPPED2 proteins expressed in the mammalian brain. dMpped, the product of CG16717, hydrolyzed phosphodiester substrates including cAMP and cGMP in a metal-dependent manner. dMpped is expressed during development and in the adult fly. RNA-seq analysis of dMppedKO flies revealed misregulation of innate immune pathways. dMppedKO flies showed a reduced lifespan, which could be restored in Dredd hypomorphs, indicating that excessive production of antimicrobial peptides contributed to reduced longevity. Elevated levels of cAMP and cGMP in the brain of dMppedKO flies was restored on neuronal expression of dMpped, with a concomitant reduction in levels of antimicrobial peptides and restoration of normal life span. We observed that dMpped is expressed in the antennal lobe in the fly brain. dMppedKO flies showed defective specific attractant perception and desiccation sensitivity, correlated with the overexpression of Obp28 and Obp59 in knock-out flies. Importantly, neuronal expression of mammalian MPPED2 restored lifespan in dMppedKO flies. This is the first description of the pleiotropic roles of an evolutionarily conserved metallophosphodiesterase that may moonlight in diverse signaling pathways in an organism.

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MyoD(Myogenic Factor 3,MYF3)

Sperbeck

Goldman

2002

Wiley Encyclopedia of Molecular Medicine

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The human MyoD1 (MYF3) gene maps on the short arm of chromosome 11 but is not associated with the WAGR locus or the region for the Beckwith-Wiedemann syndrome

Cited by 7 publications

References 25 publications

Chromosomal assignment of six muscle‐specific genes in cattle

Chromosomal assignment of six muscle‐specific genes in cattle

Neuronal expression in Drosophila of an evolutionarily conserved metallophosphodiesterase reveals pleiotropic roles in longevity and odorant response

MyoD(Myogenic Factor 3,MYF3)

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