The Human Milk Microbiota is Modulated by Maternal Diet

Padilha, Marina; Danneskiold‐Samsøe, Niels Banhos; Brejnrod, Asker; Hoffmann, Christian; Cabral, Vanessa Pereira; Iaucci, Julia de Melo; Sales, Cristiane Hermes; Fisberg, Regina Mara; Cortez, Ramon V.; Brix, Susanne; Taddei, Carla R.; Kristiansen, Karsten; Saad, Susana Marta Isay

doi:10.3390/microorganisms7110502

Cited by 61 publications

(57 citation statements)

References 61 publications

(81 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Further, milk samples from mothers who sometimes fed infants indirectly via pumped milk show decreased alpha diversity, reduced prevalence of Bifidobacterium, and increased levels of Enterobacteriaceae and Pseudomonadaceae (Moossavi et al, 2019b). Additionally, ethnicity and geographical location (Kumar et al, 2016;Ojo-Okunola et al, 2019), diet (Padilha et al, 2019a), social network size of mother-infant pairs (Meehan et al, 2018), human milk oligosaccharides and other metabolites (Gómez-Gallego et al, 2018;Moossavi et al, 2019a), as well as maternal secretor status (Cabrera-Rubio et al, 2019) have been shown to affect microbial populations in breast milk.…”

Section: Introductionmentioning

confidence: 99%

Microbial Communities in Human Milk Relate to Measures of Maternal Weight

et al. 2019

View full text Add to dashboard Cite

The process of breastfeeding exposes infants to bioactive substances including a diversity of bacteria from breast milk as well as maternal skin. Knowledge of the character of and variation in these microbial communities, as well as the factors that influence them, is limited. We aimed to identify profiles of breastfeeding-associated microbial communities and their association with maternal and infant factors. Bilateral milk samples were collected from women in the New Hampshire Birth Cohort Study at approximately 6 weeks postpartum without sterilization of the skin in order to capture the infant-relevant exposure. We sequenced the V4-V5 hypervariable region of the bacterial 16S rRNA gene in 155 human milk samples. We used unsupervised clustering (partitioning around medoids) to identify microbial profiles in milk samples, and multinomial logistic regression to test their relation with maternal and infant variables. Associations between alpha diversity and maternal and infant factors were tested with linear models. Four breastfeeding microbiome types (BMTs) were identified, which differed in alpha diversity and in Streptococcus, Staphylococcus, Acinetobacter, and Pseudomonas abundances. Higher maternal pre-pregnancy BMI was associated with increased odds of belonging to BMT1 [OR (95% CI) = 1.13 (1.02, 1.24)] or BMT3 [OR (95% CI) = 1.12 (1.01, 1.25)] compared to BMT2. Independently, increased gestational weight gain was related to reduced odds of membership in BMT1 [OR (95% CI) = 0.66 (0.44, 1.00) per 10 pounds]. Alpha diversity was positively associated with gestational weight gain and negatively associated with postpartum sample collection week. There were no statistically significant associations of breastfeeding microbiota with delivery mode. Our results indicate that the breastfeeding microbiome partitions into four profiles and that its composition and diversity is associated with measures of maternal weight.

show abstract

Section: Introductionmentioning

confidence: 99%

Microbial Communities in Human Milk Relate to Measures of Maternal Weight

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In our study, the short period of supplementation could be a factor for no statistical differences between the groups. Our recent study identified that long-term maternal dietary habits are more likely to influence the structure of the human milk microbial community, whereas short-term maternal intake induced minor changes in the microbiota composition [37].…”

Section: Discussionmentioning

confidence: 95%

Response of the Human Milk Microbiota to a Maternal Prebiotic Intervention Is Individual and Influenced by Maternal Age

et al. 2020

Self Cite

View full text Add to dashboard Cite

Maternal bacteria are shared with infants via breastfeeding. Prebiotics modulate the gut microbiota, promoting health benefits. We investigated whether the maternal diet supplementation with a prebiotic (fructooligosaccharides, FOS) could influence the milk microbiota. Twenty-eight lactating women received 4.5 g of fructooligosaccharides + 2 g of maltodextrin (FOS group) and twenty-five received 2 g of maltodextrin (placebo group) for 20 days. Breast-milk samples were taken before and after the intervention. The DNA from samples was used for 16S rRNA sequencing. No statistical differences between the groups were found for the bacterial genera after the intervention. However, the distances of the trajectories covered by paired samples from the beginning to the end of the supplementation were higher for the FOS group (p = 0.0007) indicating greater changes in milk microbiota compared to the control group. Linear regression models suggested that the maternal age influenced the response for FOS supplementation (p = 0.02). Interestingly, the pattern of changes to genus abundance upon supplementation was not shared between mothers. We demonstrated that manipulating the human milk microbiota through prebiotics is possible, and the maternal age can affect this response.

show abstract

“…However, recent evidence supports the hypothesis that, at least in part, human milk butyrate could be produced by the HMBs. The hypothesis of a pivotal contribution by mammalian gland/breast milk microbiota in butyrate production is supported by recent observations demonstrating the presence of potential butyrateproducer bugs (54,(61)(62)(63)(64)(65).…”

Section: The Potential Of Breastfeedingmentioning

confidence: 88%

Dietary Prevention of Atopic March in Pediatric Subjects With Cow's Milk Allergy

et al. 2020

View full text Add to dashboard Cite

Cow's milk allergy (CMA) is one of the most prevalent food allergies and the most expensive allergic diseases in the pediatric age. There is no cure for CMA, and actual disease management is based on strict avoidance of cow milk protein-containing foods, access to rescue medication, and use of substitutive formulas. Early-life CMA could be one of the first steps of the "allergic march" (AM), leading to the occurrence of other atopic manifestations later in the life, including asthma and oculorhinitis, with subsequent further increase of costs for health care systems and families of affected children. In the last years, diet is emerged as a relevant strategy to prevent allergic diseases through, at least in part, epigenetic modulation of immune system. We provide an overview of studies that investigate the potential role of different dietary strategies in preventing the AM in pediatric patients with CMA.

show abstract

The Human Milk Microbiota is Modulated by Maternal Diet

Cited by 61 publications

References 61 publications

Microbial Communities in Human Milk Relate to Measures of Maternal Weight

Microbial Communities in Human Milk Relate to Measures of Maternal Weight

Response of the Human Milk Microbiota to a Maternal Prebiotic Intervention Is Individual and Influenced by Maternal Age

Dietary Prevention of Atopic March in Pediatric Subjects With Cow's Milk Allergy

Contact Info

Product

Resources

About