The human microbiota is associated with cardiometabolic risk across the epidemiologic transition

Fei, Na; Bernabé, Beatriz Peñalver; Lie, Louise; Baghdan, Danny; Bedu-Addo, Kweku; Plange‐Rhule, Jacob; Forrester, Terrence; Lambert, Estelle V.; Bovet, Pascal; Gottel, Neil; Riesen, Walter; Korte, Wolfgang; Luke, Amy; Kliethermes, Stephanie; Layden, Brian T.; Gilbert, Jack A.; Dugas, Lara R.

doi:10.1101/595934

Cited by 6 publications

(2 citation statements)

References 75 publications

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“…45,[55][56][57] Although the microflora of the oral and gut environment are distinct, the genus Prevotella has been identified in subjects with periodontitis and subjects with obesity. 48,[58][59][60] Additionally, Tannerella forsythia, a common periodontal pathogen, is identified in obese individuals with clinical periodontal health. 61,62 These studies show that there may be a link between the oral and gut microbiome and health.…”

Section: Microbiomementioning

confidence: 99%

Waistline to the gumline: Relationship between obesity and periodontal disease‐biological and management considerations

Ganesan

Vazana

Stuhr

2021

Periodontology 2000

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Obesity, defined as a body mass index of >30 kg/m 2 , 1 occurs when excess fat accumulation (regionally and/or globally) increases adverse health risks. With a global surge in prevalence, obesity and its associated comorbidities exert a significant economic and health burden on our society. Obesity is known to increase the risk of several chronic conditions, including type 2 diabetes, cancer, and cardiovascular diseases. 2 Additionally, new evidence is emerging to show a potential bidirectional relationship between obesity and periodontal disease. 3,4 The recent 2017 classification of periodontal diseases and conditions recognized obesity as a systemic factor affecting periodontal health. In particular, the role of obesity in worsening periodontal inflammation and in increasing the risk of developing periodontitis has been recognized. 5 Exploring the potential link between obesity and periodontal disease is currently an area of active research, and the shared molecular and environmental underpinnings between obesity and periodontal disease have been comprehensively reviewed by several groups. 3,[6][7][8][9][10] However, literature on the logistics of managing this special cohort remain scarce.With more than one-third of US adults being overweight or obese, encountering these patients in periodontal practices is a routine occurrence. Therefore, in addition to reviewing the biologic interlinks between obesity and periodontal disease, this review delineates practical considerations for managing these patients in an everyday periodontal practice setting.

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Section: Microbiomementioning

confidence: 99%

Waistline to the gumline: Relationship between obesity and periodontal disease‐biological and management considerations

Ganesan

Vazana

Stuhr

2021

Periodontology 2000

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“…With global research findings on the apparent dysbiosis of the gut microbiome in obesity being rather inconclusive [30][31][32][33] , we sought to evaluate the differences between obese and lean individuals within and between the two study populations. The within site differences based on alpha (Shannon) diversity were moderate and did not reach statistical significance.…”

Section: Algerian Tuaregs Saudi Bedouins and Amazonians From French mentioning

confidence: 99%

Gut Microbiome Profiling of a Rural and Urban South African Cohort Reveals Biomarkers of a Population in Lifestyle Transition

Oduaran

Tamburini

Sahibdeen

et al. 2020

Preprint

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Background: Comparisons of traditional hunter-gatherers and pre-agricultural communities in Africa with urban and suburban Western North American and European cohorts have clearly shown that diet, lifestyle and environment are associated with gut microbiome composition. Yet, little is known about the gut microbiome composition of most African adults. South Africa comprises a richly diverse ethnolinguistic population that is experiencing an ongoing epidemiological transition and concurrent spike in the prevalence of obesity, largely attributed to a shift towards more Westernized diets and increasingly inactive lifestyle practices. To better characterize the microbiome of African adults living in more mainstream lifestyle settings and to investigate associations between the microbiome and obesity, we conducted a pilot study in two South African cohorts that are representative of urban and rural populations. The study was designed collaboratively with community leaders. As the rate of overweight and obesity is particularly high in women, we collected single time-point stool samples from 170 HIV-negative women (51 at Soweto; 119 at Bushbuckridge), performed 16S rRNA gene sequencing on these samples and compared the data to concurrently collected anthropometric data. Results:We found the overall gut microbiome of our cohorts to be reflective of their ongoing epidemiological transition. Specifically, our results show a relatively higher than expected abundance of Western gut-associated taxa such as Barnesiella and the presence of Bifidobacteria and Bacteroides together with the more traditionally non-Western gut-associated Prevotella, Treponema and Succinivibrio. Interestingly, we observed a relatively higher abundance of the Melainabacteria, Vampirovibrio, a predatory bacterium, in the rural cohort. We also found Prevotella, despite its generally high prevalence relative to all taxa present in the cohort, to be associated with obesity. Conclusions:Altogether, this work identifies putative microbial features associated with host health in a historically understudied community. Furthermore, we note the crucial role of community engagement to the success of a study in an African setting, the importance of more population-specific studies to inform targeted interventions as well as present a basic foundation for future research in this regard.

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The Role of Dysbiotic Oral Microbiota in Cardiometabolic Diseases: A Narrative Review

Lê,

Cecchin-Albertoni,

Thomas

et al. 2023

Diagnostics

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Over the past decade, there have been significant advancements in the high-flow analysis of “omics,” shedding light on the relationship between the microbiota and the host. However, the full recognition of this relationship and its implications in cardiometabolic diseases are still underway, despite advancements in understanding the pathophysiology of these conditions. Cardiometabolic diseases, which include a range of conditions from insulin resistance to cardiovascular disease and type 2 diabetes, continue to be the leading cause of mortality worldwide, with a persistently high morbidity rate. While the link between the intestinal microbiota and cardiometabolic risks has been extensively explored, the role of the oral microbiota, the second-largest microbiota in the human body, and specifically the dysbiosis of this microbiota in causing these complications, remains incompletely defined. This review aims to examine the association between the oral microbiota and cardiometabolic diseases, focusing on the dysbiosis of the oral microbiota, particularly in periodontal disease. Additionally, we will dive into the mechanistic aspects of this dysbiosis that contribute to the development of these complications. Finally, we will discuss potential prevention and treatment strategies, including the use of prebiotics, probiotics, and other interventions.

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The human microbiota is associated with cardiometabolic risk across the epidemiologic transition

Cited by 6 publications

References 75 publications

Waistline to the gumline: Relationship between obesity and periodontal disease‐biological and management considerations

Waistline to the gumline: Relationship between obesity and periodontal disease‐biological and management considerations

Gut Microbiome Profiling of a Rural and Urban South African Cohort Reveals Biomarkers of a Population in Lifestyle Transition

The Role of Dysbiotic Oral Microbiota in Cardiometabolic Diseases: A Narrative Review

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