The human malaria-
Aotus
monkey model: a historical perspective in antimalarial chemotherapy research at the Gorgas Memorial Laboratory-Panama
Nicanor Obaldía
Abstract:The human malaria-
Aotus
monkey model has served the malaria research community since its inception in 1966 at the Gorgas Memorial Laboratory (GML) in Panama. Spanning over five decades, this model has been instrumental in evaluating the
in vivo
efficacy and pharmacokinetics of a wide array of candidate antimalarial drugs, whether used singly or in combination. The animal model could be infected with drug-resistant and susceptible
Plasmodium… Show more
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