The human leukocyte antigen class II gene has different contributions to autoimmune Type 1 diabetes with or without autoimmune thyroid disease in the Japanese population

Katahira, Masahito; Maeda, Harumi; Tosaki, Takahiro; Segawa, Satoko

doi:10.1016/j.diabres.2009.06.007

Cited by 21 publications

(18 citation statements)

References 21 publications

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“…(27). This female predominance, 4.4 times as many females as males, was more obvious than those reported previously by us (28,29) and others (23,30), which ranged from 1.4 to 2.5. The higher female-to-male ratio in patients with APS3v in the present study may possibly be explained by the different definition of HT.…”

Section: Discussioncontrasting

confidence: 39%

Clinical and Genetic Characteristics of Autoimmune Polyglandular Syndrome Type 3 Variant in the Japanese Population

Horie

Kawasaki

Ando³

et al. 2012

The Journal of Clinical Endocrinology &Amp; Metabolism

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Section: Discussioncontrasting

confidence: 39%

Clinical and Genetic Characteristics of Autoimmune Polyglandular Syndrome Type 3 Variant in the Japanese Population

Horie

Kawasaki

Ando³

et al. 2012

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…Since 15 to 30% of subjects with T1D have AITD [44][45][46], the effect of these amino acids on T1D may be susceptibility, and that on T1D-AITD might be susceptibility or neutrality, which is weaker than that on T1D or T1D+AITD. There are few reports concerning the effect of HLA DR-DQ genes on T1D-AITD in the Caucasian [57], Japanese [59,61,62], and Taiwan Chinese [60] populations (Table 4). The DRB1*07:01-DQA1*02:01-DQB1*02:02 and DRB1*16:02-DQA1*01:02-DQB1*05:02 haplotypes are rare in the Japanese population [8][9][10]49].…”

Section: Relationship Between T1d±aitd and Amino Acidmentioning

confidence: 99%

“…There are several reports concerning the effect of HLA DR-DQ genes on T1D+AITD, which also studied Caucasian [18,57,63], Japanese [22,58,59,61,62], and Taiwan Chinese [60] populations (Table 4). The DRB1*16:02-DQA1*01:02-DQB1*05:02 haplotype is rare in the Caucasian population as well as in the Japanese population [49], and Menconi et al did not examine patients and controls with the DR16 allele [18].…”

Section: Drb1mentioning

confidence: 99%

The Relationship Between Human Leukocyte Antigen Class II Genes and Type 1 Diabetes, Autoimmune Thyroid Diseases, and Autoimmune Polyendocrine Syndrome Type 3

Katahira¹

2014

HLA and Associated Important Diseases

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“…It is appeared that children with β-cell auto antibodies such an Anti-GAD and also specific HLA subtypes such as HLA-D1QB1*0302 are associated with greater risk of developing anti-thyroid antibodies (40)(41)(42)(43). Indeed, there is a close association between specific thyroid auto antibodies such as microsomal and peroxidase antibodies and anti-pancreatic β-cells auto antibodies and an increased prevalence of thyroid antibodies occur in T1DM patients with ATD, but the reasons for this increased frequency remained obscure (44)(45)(46)(47).…”

Section: Contextmentioning

confidence: 99%

Type 1 Diabetes Mellitus Associated With Autoimmune Thyroid Disorders in Iranian Children: A Review

Zamanfar¹,

Aarabi²,

Sadeghian³

2015

J Pediatr Rev

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Context: Type one diabetes mellitus (T1DM) is an autoimmune disorder that is yet the most common type of diabetes in children and adolescents. Several genetic risk factors have been associated with T1DM, auto immune thyroiditis and other autoimmune disorder. Among autoimmune disorders, autoimmune thyroid disease (ATD) is the most frequent disorder associated with T1DM. Its prevalence varies depending on age, sex and ethnic origin of the subjects and is considerably higher than the general population and increases with duration of T1DM. The aim of this study was to review the prevalence of ATD in Iranian children with T1DM compared with other countries. Evidence Acquisition: We conducted a review on all papers published on the association between autoimmune thyroiditis and T1DM, which was available on Google Scholar, Scientific Information Database (SID), Magiran and Iran Medex databases up to June 2014. Both Persian and English articles were checked. The searched terms were: diabetes mellitus, autoimmune thyroiditis, prevalence, frequency, Iranian children and adolescents. All papers which were done on patients with age under 20 years old and have used Anti-TPO and Anti-TG to evaluate patients were included. Results: Six papers met all the criteria. A total of 736 participants were included in this review. After review of all the papers, the prevalence of Anti-TPO was reported between 8% and 30% and Anti-TG was reported 6.06% to 23.6% in diabetic children in Iran. Conclusions: Autoimmune thyroid disorders are the most prevalent immunological diseases in patients with type 1 diabetes. All these studies have shown a higher prevalence of the disorder in patients with T1DM compared to the Iranian healthy population. Anti-TPO reported between 8% and 30% and Anti-TG reported 6.06% to 23.6% in diabetic children in Iran that was similar to the studies in other countries.

show abstract

The human leukocyte antigen class II gene has different contributions to autoimmune Type 1 diabetes with or without autoimmune thyroid disease in the Japanese population

Cited by 21 publications

References 21 publications

Clinical and Genetic Characteristics of Autoimmune Polyglandular Syndrome Type 3 Variant in the Japanese Population

Clinical and Genetic Characteristics of Autoimmune Polyglandular Syndrome Type 3 Variant in the Japanese Population

The Relationship Between Human Leukocyte Antigen Class II Genes and Type 1 Diabetes, Autoimmune Thyroid Diseases, and Autoimmune Polyendocrine Syndrome Type 3

Type 1 Diabetes Mellitus Associated With Autoimmune Thyroid Disorders in Iranian Children: A Review

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