The human leucocyte differentiation antigens (HLDA) workshops: the evolving role of antibodies in research, diagnosis and therapy

Abstract

The 8 th International Workshop on Human Leucocyte Differentiation Antigens (chaired by Zola H and managed by Swart B) was run over a 4-year period and culminated in a conference in December 2004. Here we review the achievements of the HLDA Workshops and provide links to information on CD molecules and antibodies against them, including the 93 new CDs assigned in the 8 th Workshop. We consider what remains to be achieved (including an estimate of the number of leucocyte surface molecules still to be discovered), and how the field can best move forward.

Leukocyte count affects expression of reference genes in canine whole blood samples

“…At least 350 CD markers are defined in humans [17,18], while in the first and to date only workshop on canine leukocyte antigens only 127 antibodies were investigated [19]. A more recent study tested cross species reactivity with commercially available anti human CD molecules against canine leukocytes, erythrocytes and platelets and identified only a limited number of 51 cross reacting mAbs [20].…”

Editorial HLDA9 special issue

“…Most of the molecules used both in research and diagnosis by immunologists, hematologists and pathologists derive from the HLDA Workshops [1]. Indeed, for more than 25 years, HLDA Workshops and Conferences have been responsible for maintaining the CD nomenclature.…”

Aptamers for CD Antigens: From Cell Profiling to Activity Modulation

“…Many anti-CD antibodies have been shown to be efficient in immunosuppression, 4 cancer therapy, 5 and transplant tolerance 6 . Additionally, CD molecules have a vast amount of applications in cell phenotyping and disease diagnosis 7 . Some CD molecules are better known than others because of their pivotal role in immune system homeostasis, such as CD4, CD8, CD3, CD28, CD45, and CD80 8 .…”