The Human Intraocular Penetration of Methicillin

The Penetration of Vibramycin (Doxycycline) in Human Aqueous Humor

“…Green et al [28] studied a patient with endophthalmitis and found a very high intraocular penetration of amphotericine B. Recently, Records [31] showed that methicillin penetrates intraocularly to give high antibiotic concentrations, whereas the pene tration of this drug in normal eyes is negligible. Further studies by the same author [32] on cephalothin penetration into the aqueous, where he recreated the same blood-aqueous humor barrier condi tion that are seen in inflammed eyes, found a high concentration of the antibiotic in the secondary aqueous humor.…”

“…Records [31], on the other hand, found that the aqueous humor of a diabetic patient contained high levels of methacillin and feels that there is a slight alteration in the blood-aqueous humor barrier, which permits organic acids to pass and prevents the passage of large protein molecules, which might appear in the aqueous humor of inflammed eyes.…”

Current approach to postoperative endophthalmitis

“…Penicillin penetration into the aqueous and vitreous humours is generally poor84 85 even in the inflamed eye 86. Intraocular levels can be improved by concomitant use of probenecid, a tubule blocking drug87; that is, however, rarely used in practice.…”

Pharmacokinetics of β-Lactam Antibiotics

“…Detectable amounts of methicillin are present in CSF (BUNN et al 1960;BAR-TOWZZI et al 1967). Methicillin does not penetrate into the aqueous humor of human eyes except when the blood-aqueous barrier has been altered by disease or local inflammatory processes (RECORDS 1966). In the dog, the lymph to plasma concentration ratio is 0.96 at steady state (VERWAY and WILLIAMS 1962).…”