The human first cell cycle; impact on implantation

Aguilar, Jesús; Motato, Y.; Louzao, M. Carmen; Escribá, Marı́a José; Muñoz, Elkin; Meseguer, M.

doi:10.1016/j.fertnstert.2013.07.1229

Cited by 14 publications

(19 citation statements)

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“…Other studies had also found that early PNf is a good indicator of embryo quality and viability [32][33][34]. PNf has been shown to have a significant effect on achieving pregnancy and implantation when implanted embryos had earlier PNf than nonimplanted embryos [33,35,36]. The findings of the current study support those of earlier works that linked embryonic divisions to blastocyst formation, ploidy, viability, and implantation success [18,37,38].…”

Section: Discussionsupporting

confidence: 87%

Time-lapse imaging reveals delayed development of embryos carrying unbalanced chromosomal translocations

Amir

Barbash‐Hazan

Kalma

et al. 2018

J Assist Reprod Genet

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Purpose The purpose of the study was to compare the morphokinetic parameters of embryos carrying balanced chromosomal translocations with those carrying unbalanced chromosomal translocations using time-lapse microscopy. Methods The study group included 270 embryos that underwent biopsies on day 3 for preimplantation genetic diagnosis (PGD) for chromosomal translocations in our unit between 2013 and 2015. All embryos were incubated under time-lapse microscopy and evaluated for timing of developmental events up to day 5. The timing of these events was compared between balanced and unbalanced embryos, potentially viable and nonviable variants, and maternal versus paternal inheritance of the translocation. Results The PGD analysis found that 209 (77%) of the 270 biopsied embryos carried an unbalanced translocation. Embryos carrying unbalanced translocations, which are expected to lead to implantation failure or miscarriage, cleaved less synchronously and were delayed in time of cleavage to the 4-cell stage (t4) and in time of start of blastulation (tSB) compared with balanced embryos (P < 0.05). Furthermore, embryos carrying nonviable translocations demonstrated a significant delay at the time of pronuclei fading (tPNf) compared with those carrying potentially viable translocations (P < 0.05). Embryos whose unbalanced translocations were of maternal origin were significantly delayed in most of the morphokinetic parameters (including tPNf, t2, t3, t4, t6, t7, t8, cc2, s2, and tSB) compared with embryos carrying balanced translocations (P < 0.05). Conclusions Embryos carrying unbalanced chromosomal translocations mainly of maternal origin undergo delayed development and asynchronous cleavage that may lead to implantation failure or miscarriage.

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Section: Discussionsupporting

confidence: 87%

Time-lapse imaging reveals delayed development of embryos carrying unbalanced chromosomal translocations

Amir

Barbash‐Hazan

Kalma

et al. 2018

J Assist Reprod Genet

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“…Strong correlations have been demonstrated between embryo kinetics and embryo viability (10,(13)(14)(15)(16)(17)(18)(19) and other factors, such as ploidy (17,20,21), ovarian reserve (22), ovarian response to stimulation (23), women's age (24,25), women's body mass index (26), smoking habits (27), incubation atmosphere during embryo culture (5), embryo culture media (28,29), embryo biopsy (30)(31)(32), fertilization method (8,33), and sperm cryopreservation (34).…”

mentioning

confidence: 99%

Study of nucleation status in the second cell cycle of human embryo and its impact on implantation rate

Aguilar

Rubio

Muñoz

et al. 2016

Fertility and Sterility

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“…A similar approach to implantation modelling was employed by Aguilar et al [14]. The authors determined the optimal ranges of morphokinetic parameters and used the values outside of these ranges as indicators of reduced implantation potential.…”

Section: Discussionmentioning

confidence: 99%

Morphokinetic parameters as a source of information concerning embryo developmental and implantation potential

et al. 2016

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Objectives: The aim of the study was to present the results of time-lapse observation and to verify whether morphokinetic parameters are associated with embryo developmental and implantation potential. Material and methods:The analysed data concern the development of 1,060 embryos, 898 of which (84.72%) achieved the blastocyst stage and 307 were transferred into the uterine cavity. As a result, 126 (41.04%) biochemical pregnancies and 109 (35.50%) clinical pregnancies were observed. Time from fertilisation to further divisions into 2-9 blastomeres, first to fourth round of cleavage, second to third synchronisation parameters and the duration of stages after the first, second and third division were analysed. Results:Most of the parameters in the group of embryos developed to the blastocyst stage reached lower values than in the non-developed group. Moreover, parameters in the first group clearly had less dispersion. The differences between the groups with and without a biochemical pregnancy were smaller than the differences in the analysis of development to the blastocyst stage. However, in the case of clinical pregnancy analysis, there were again larger differences between both groups. A strong correlation was found between the majority of absolute morphokinetic parameters. A weaker, but still statistically significant correlation, was established between relative and other parameters. Conclusions:Morphokinetic parameters are associated with embryo developmental and implantation potential and can be considered as predictors of their quality. However, the development of efficient pregnancy prediction models needs further research utilising information from all available parameters and using advanced biostatistical methods.

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The human first cell cycle; impact on implantation

Cited by 14 publications

References 0 publications

Time-lapse imaging reveals delayed development of embryos carrying unbalanced chromosomal translocations

Time-lapse imaging reveals delayed development of embryos carrying unbalanced chromosomal translocations

Study of nucleation status in the second cell cycle of human embryo and its impact on implantation rate

Morphokinetic parameters as a source of information concerning embryo developmental and implantation potential

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