The human FCG1 gene encoding the high-affinity Fc?RI maps to chromosome 1q21

Dietzsch, E.; Osman, Narin; McKenzie, Steven E.; Garson, Margaret; Hogarth, P. Mark

doi:10.1007/bf00188811

Cited by 7 publications

(5 citation statements)

References 17 publications

(15 reference statements)

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“…This Finding, based on data derived from both FCGR1 FISH analy sis of human lymphocyte chromosomes and genomic Southern analysis of cell lines containing either the short or long arm of chromosome 1, differs from previous reports which localized all three genes to 1 q21 (Dietzsch et al, 1993;de Wit et al, 1993).…”

Section: Discussionmentioning

confidence: 89%

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The three genes of the human FCGR1 gene family encoding FcγRI flank the centromere of chromosome 1 at 1p12 and 1q21

Maresco¹,

Chang²,

Theil

et al. 1996

Cytogenet Genome Res

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The high-affinity receptor for immunoglobulin G, FcγRI (FCGR1), is encoded by a family of three genes within humans that share over 98% of DNA sequence homology. Efforts to define the location of the FCGR1 genes within chromosome 1 have been made to determine if they are tightly linked to the five other FCGR genes present at 1q23. Our results, obtained through both fluorescence in situ hybridization analysis of human cells and Southern analysis of cell lines containing 1p and 1q, show instead that the three genes flank the centromere of chromosome 1 at bands 1p12 and 1q21. FCGR1B was found at 1p12, whereas both FCGR1A and FCGR1C were localized to 1q21. This places the FCGRl gene family within a large pericentric linkage group which is conserved between humans and mice. We hypothesize that the three FCGRl genes were separated by a pericentric inversion, known to have occurred on human chromosome 1 which relocated FCGR1A and FCGR1C to the long arm and left FCGR1B positioned on the short arm. We have also performed FCGRl gene copy number experiments which indicate the existence of three FCGR1 genes within the human genome.

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Section: Discussionmentioning

confidence: 89%

“…1989;Qiu et al, 1990). In contrast to others (Dietzsch et al, 1993;de Wit et al, 1993), we find through both fluorescence in situ hybridization (FISH) analysis of human cells and Southern analysis of cell lines con taining Ip and lq. that the three FCGR1 genes flank the cen tromere of chromosome 1 at bands 1 p 12 and lq21.…”

mentioning

confidence: 99%

The three genes of the human FCGR1 gene family encoding FcγRI flank the centromere of chromosome 1 at 1p12 and 1q21

Maresco¹,

Chang²,

Theil

et al. 1996

Cytogenet Genome Res

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“…The specific position of FcγRI has recently been called into question because of differing placement by genome mapping projects. According to the latest approximation by the National Center for Biotechnology Information (NCBI) we have provisionally placed it in a location that correlates with its original positioning (100, 101).…”

Section: Genomic Diversity Of the Fc Receptor Clustermentioning

confidence: 99%

Fc receptor homologs: newest members of a remarkably diverse Fc receptor gene family

Davis¹,

Dennis

Odom

et al. 2002

Immunological Reviews

115

107

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Newfound relatives of the classical Fc receptors (FcR) have been provisionally named the Fc receptor homologs (FcRH). The recent identification of eight human and six mouse FcRH genes substantially increases the size and functional potential of the FcR family. The extended family of FcR and FcRH genes spans approximately 15 Mb of the human chromosome 1q21-23 region, whereas in mice this family is split between chromosomes 1 and 3. The FcRH genes encode molecules with variable combinations of five subtypes of immunoglobulin (Ig) domains. The presence of a conserved sequence motif in one Ig domain subtype implies Ig Fc binding capability for many FcRH family members that are preferentially expressed by B lineage cells. In addition, most FcRH family members have consensus tyrosine-based activating and inhibitory motifs in their cytoplasmic domains, while the others lack features typical of transmembrane receptors. The FcRH family members, like the classical FcRs, come in multiple isoforms and allelic variations. The unique individual and polymorphic properties of the FcR/FcRH members indicate a remarkably diverse Fc receptor gene family with immunoregulatory function.

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“…These include the genes for CR1, the receptor for the C3b and C4b complement components; CR2, the C3d and Epstein Barr virus receptor; factor H; C4 binding protein; decay accelerating factor; and membrane cofactor protein (Bruns and Dracopoli 1991). The gene encoding the polymeric immunoglobulin receptor has also been mapped to lq31, and a variety of immunoglobulin Fc receptor genes are present in the more centromeric 1@3 (Bruns and Dracopoli 1991) and lq31 bands (Dietzsch et al 1993). Abnormally low levels of CR1 have been reported on cells of SLE patients (Iida et al 1982;Van Dyne et al 1987;Walport and Lachmann 1988;Mir et al 1988).…”

mentioning

confidence: 99%

Mapping of the human 60 000 M r Ro/SSA locus: the genes for three Ro/SSA autoantigens are located on separate chromosomes

Frank

Matteï

1994

Immunogenetics

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The human FCG1 gene encoding the high-affinity Fc?RI maps to chromosome 1q21

Cited by 7 publications

References 17 publications

The three genes of the human FCGR1 gene family encoding FcγRI flank the centromere of chromosome 1 at 1p12 and 1q21

The three genes of the human FCGR1 gene family encoding FcγRI flank the centromere of chromosome 1 at 1p12 and 1q21

Fc receptor homologs: newest members of a remarkably diverse Fc receptor gene family

Mapping of the human 60 000 M r Ro/SSA locus: the genes for three Ro/SSA autoantigens are located on separate chromosomes

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