The Human Endolymphatic Sac: An Ultrastructural

Bagger‐Sjöbäck, Dan; Friberg, Ulla; Rask‐Andersen, Helge

doi:10.1001/archotol.1986.03780040038008

Cited by 57 publications

(26 citation statements)

References 19 publications

(1 reference statement)

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“…More controlled animal experiments using tracer substances placed in the endolymph of the cochlea and vestibule led to further knowledge of this process [41,42]. TEM studies on the human ES have shown disintegration and phagocytosis of red blood cells and the luminal contents of cell debris, collagen fibres and otoconia [11]. In patients with MD and acoustic neuroma, the luminal contents often included cellular debris, originating chiefly from the ES [13,14].…”

Section: Discussionmentioning

confidence: 99%

“…Waste products from the rest of the inner ear are believed to be transported to the ES by the longitudinal flow of endolymph [1]. Studies on the human ES with transmission electron microscopy (TEM) have revealed degenerated cell products [11], red blood corpuscles, discarded otoconia and collagen fibres [12] in the lumen. TEM studies on ES from patients with Ménière's disease (MD) and acoustic neuroma showed that luminal contents often included degenerated cell products originating mainly from the ES itself [13,14].…”

Section: Introductionmentioning

confidence: 99%

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Stereocilia-Like Structures in the Endolymphatic Sac in Ménière’s Disease and Acoustic Neuroma

Danckwardt-Lillieström

Friberg²,

Kinnefors³

et al. 1998

ORL

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The vestibular aqueduct was surgically removed in 3 patients undergoing labyrinthectomy due to severe Ménière’s disease (MD). Stereocilia-like structures were found in the luminal contents of the endolymphatic sac (ES) in all of these patients. The ES from 18 patients with acoustic neuroma were used as controls. In 1 of these, numerous stereocilia-like structures were found in the ES and in 3 additional patients, a few isolated cilia-like structures were disclosed. The findings may suggest an ongoing hair cell degeneration in the inner ear that is more advanced in patients with MD. The data also suggest that the endolymphatic duct is patent and that a longitudinal flow of endolymph also occurs in patients with MD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Stereocilia-Like Structures in the Endolymphatic Sac in Ménière’s Disease and Acoustic Neuroma

Danckwardt-Lillieström

Friberg²,

Kinnefors³

et al. 1998

ORL

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“…00720. the situation in man. Lately, several studies, performed with modern techniques, such as electron microscopy and freeze fracturing, have demonstrated the detailed structure of the endolymphatic duct and sac in man [1,2], To some extent, these studies have given us new con cepts of the complex morphology of the adult human sac, which are important not only in a scientific way, but also for the practicing surgeon intending to operate on the sac in cases with Meniere's disease.…”

mentioning

confidence: 99%

Embryology of the Human Endolymphatic Duct and Sac

Bagger‐Sjöbäck

1991

ORL

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Endolymphatic sac specimens from human embryos, ranging in age from 8 to 20 weeks, were examined in order to get a good understanding of the embryological development. The gross development can be separated into three phases, with the first phase terminating around week 10, the second phase between weeks 11 and 15–16 and the third phase lasting to week 20. While presenting as an immature oval appendage emanating from the vestibule in the first phase, the sac then develops into its more mature shape with crypts and folds within the epithelial lining. The third period is characterized by splitting up of the lumen into separate tubules. The epithelial cells differentiate particularly during the second and third phases with light- and dark-staining cells as well as granulated cells. It is evident that the development of the endolymphatic sac is not finished by week 20, even though it has attained many of its adult characteristics.

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“…These results may be used in parallel with ear lier results from electron-microscopic investigations of the human ED and ES. removed from cadavers shortly after death [12,13].…”

Section: Discussionmentioning

confidence: 99%

A Technique to Obtain and Process Surgical Specimens of the Human Vestibular Aqueduct for Histopathological Studies of the Endolymphatic Duct and Sac

Danckwardt-Lillieström

Rask‐Andersen²,

Linthicum³

et al. 1992

ORL

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The endolymphatic sac (ES) may play a crucial role in the pathophysiology of Ménière’s disease. This paper presents a technique to obtain and process fresh human specimens of the endolymphatic duct (ED) and the presumably more active intraosseous portion of the ES obtained at surgery. The specimens are preserved with an intact bony shell around the ED and the intraosseous ES. This allows ultrastructural histopathological evaluation of the intraluminal contents, the epithelium and the subepithelial tissue as well as the mutual relationships of these structures. Various factors influencing ES ultrastructure are discussed. The results obtained from this method may increase our understanding of the possible role of the ES in the etiology of different inner ear disorders.

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The Human Endolymphatic Sac: An Ultrastructural

Cited by 57 publications

References 19 publications

Stereocilia-Like Structures in the Endolymphatic Sac in Ménière’s Disease and Acoustic Neuroma

Stereocilia-Like Structures in the Endolymphatic Sac in Ménière’s Disease and Acoustic Neuroma

Embryology of the Human Endolymphatic Duct and Sac

A Technique to Obtain and Process Surgical Specimens of the Human Vestibular Aqueduct for Histopathological Studies of the Endolymphatic Duct and Sac

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