Phys. Chem. Chem. Phys.
 2024
DOI: 10.1039/d3cp05736d
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The human eIF4E:4E-BP2 complex structure for studying hyperphosphorylation

Juan Zeng,
CuiMin Lu,
Xuan Huang
et al.

Abstract: The cap-dependent mRNA translation is dysregulated in many kinds of cancers. The interaction between eIF4E and eIF4G through a canonical eIF4E-binding motif (CEBM) determines the efficacy of the cap-dependent mRNA...

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