The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T-cell recognition by targeting CIITA
Fabienne Maaßen,
Vu Thuy Khanh Le-Trilling,
Luisa Betke
et al.
Abstract:Human cytomegalovirus (HCMV) is a relevant pathogen especially for individuals with impaired immunity. Harnessing potent immune antagonists, HCMV circumvents sterile immunity. Given that HCMV prevents the upregulation of human leukocyte antigen (HLA)-DP and HLA-DR, we screened a library of HCMV genes by co-expression with the HLA class II (HLA-II)-inducing transcription coordinator class II transactivator (CIITA). We identified the latency regulator pUS28 as interaction factor and potent viral antagonist of CI… Show more
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