The human cerebellum contributes to motor, emotional and cognitive associative learning. A review

Timmann, Dagmar; Drepper, Johannes; Frings, Markus; Maschke, Matthias; Richter, Stefanie; Gerwig, Marcus; Kolb, Florian P.

doi:10.1016/j.cortex.2009.06.009

Cited by 310 publications

(215 citation statements)

References 105 publications

Supporting

Mentioning

197

Contrasting

Unclassified

Order By: Relevance

“…Syndromes such as ataxia are most commonly attributed to deficiencies in this structure (Steinlin 2008;Basson and Wingate 2013). However, more recent human imaging and cerebellar injury studies have broadened the scope of cerebellar function to include aspects of cognition, associative learning, emotional response, and behavior (Timmann et al 2010). Indeed, studies of ASD have also reported links with abnormal cerebellar anatomy or function (Courchesne et al 2011;Skefos et al 2014).…”

Section: Discussionmentioning

confidence: 99%

NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development

et al. 2014

View full text Add to dashboard Cite

Cerebellar development is regulated by a coordinated spatiotemporal interplay between granule neuron progenitors (GNPs), Purkinje neurons, and glia. Abnormal development can trigger motor deficits, and more recent data indicate important roles in aspects of memory, behavior, and autism spectrum disorders (ASDs). Germline mutation in the NF1 tumor suppressor gene underlies Neurofibromatosis type 1, a complex disease that enhances susceptibility to certain cancers and neurological disorders, including intellectual deficits and ASD. The NF1 gene encodes for neurofibromin, a RAS GTPase-activating protein, and thus negatively regulates the RAS signaling pathway. Here, using mouse models to direct conditional NF1 ablation in either embryonic cerebellar progenitors or neonatal GNPs, we show that neurofibromin is required for appropriate development of cerebellar folia layering and structure. Remarkably, neonatal administration of inhibitors of the ERK pathway reversed the morphological defects. Thus, our findings establish a critical cell-autonomous role for the NF1-RAS-ERK pathway in the appropriate regulation of cerebellar development and provide a basis for using neonatal ERK inhibitor-based therapies to treat NF1-induced cerebellar disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development

et al. 2014

View full text Add to dashboard Cite

show abstract

“…As discussed in the previous section, although the cerebellar vermis participates in fear-related somatic and autonomic aspects, the posterolateral hemispheres have been proposed to mediate the emotional content of fear conditioning at higher cognitive levels [114]. This assumption is supported by the presence of connections between the cerebellar hemispheres and the more ventral and caudal areas of the dentate nucleus, which in turn are connected to the temporal, parietal, and prefrontal cortices [115], which are involved in cognitive elaboration of emotional content [32].…”

Section: Cerebellar Involvement In the Conscious Component Of Emotionsmentioning

confidence: 99%

“…Furthermore, activation of the posterolateral cerebellar hemispheres is observed in the late acquisition phase of fear conditioning that is linked to the conscious elaboration of emotional content of associative learning [79,114].…”

Section: Cerebellar Involvement In the Conscious Component Of Emotionsmentioning

confidence: 99%

The Role of the Cerebellum in Unconscious and Conscious Processing of Emotions: A Review

et al. 2017

View full text Add to dashboard Cite

Abstract:Studies from the past three decades have demonstrated that there is cerebellar involvement in the emotional domain. Emotional processing in humans requires both unconscious and conscious mechanisms. A significant amount of evidence indicates that the cerebellum is one of the cerebral structures that subserve emotional processing, although conflicting data has been reported on its function in unconscious and conscious mechanisms. This review discusses the available clinical, neuroimaging, and neurophysiological data on this issue. We also propose a model in which the cerebellum acts as a mediator between the internal state and external environment for the unconscious and conscious levels of emotional processing.

show abstract

“…T he vertebrate cerebellum is involved in controlling balance, body posture, smooth performance of movements, and likely, conditioning and motor learning (1)(2)(3)(4). It is, thus, interconnected in many ways with other brain regions, such as the cortex and the spinal cord.…”

mentioning

confidence: 99%

Functional regionalization of the teleost cerebellum analyzed in vivo

Matsui

Namikawa

Babaryka

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

178

View full text Add to dashboard Cite

There has been accumulating evidence for a regionalized organization of the cerebellum, which was mostly deduced from anatomical mapping of axonal projections of cerebellar afferents. A likewise regionalization of the cerebellar output has been suggested from lesion studies and dye-tracer experiments, but its physiological targets as well as the functional relevance of such an output regionalization are less clear. Ideally, such functional regionalization should be proven noninvasively in vivo. We here provide evidence for such a regionalization of the output from the cerebellar cortex by genetically encoded transneuronal mapping of efferent circuits of zebrafish Purkinje neurons. These identified circuits correspond to distinct regionalized Purkinje cell activity patterns in freely behaving zebrafish larvae during the performance of cerebellar-dependent behaviors. Furthermore, optogenetic interrogation of selected Purkinje cell regions during animal behavior confirms the functional regionalization of Purkinje cell efferents and reveals their contribution to behavior control as well as their function in controlling lateralized behavioral output. Our findings reveal how brain compartments serve to fulfill a multitude of functions by dedicating specialized efferent circuits to distinct behavioral tasks.

show abstract

The human cerebellum contributes to motor, emotional and cognitive associative learning. A review

Cited by 310 publications

References 105 publications

NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development

NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development

The Role of the Cerebellum in Unconscious and Conscious Processing of Emotions: A Review

Functional regionalization of the teleost cerebellum analyzed in vivo

Contact Info

Product

Resources

About