The Human Cell Atlas Project by the numbers: Relationship to the Banff Classification

Diagnosis of renal transplant rejection: Banff classification and beyond

“…Lastly, with recent advances in bioengineered organs, we may also need to implement strategies to deal with abnormalities in bioengineered organs. Recently, Solez et al [67] proposed the construction of a framework for the classification of tissue engineering pathology at future Banff Transplant Pathology meetings, in collaboration with the Human Cell Atlas project [68].…”

Anatomical Structures, Cell Types, and Biomarkers Tables Plus 3D Reference Organs in Support of a Human Reference Atlas

“…1a shows a bimodal network of 16 consortia that focus on human atlas construction and the 30 organs they study, including efforts funded by the National Institutes of Health (NIH, blue) and cross-fertilized by the international Human Cell Atlas (HCA, red) 3, 4 . Consortia include the Allen Brain Atlas 5 , the Brain Research through Advancing Innovative Neurotechnologies Initiative - Cell Census Network (BICCN) Initiative 6 , Chan Zuckerberg Initiative Seed Networks for HCA (CZI) 3, 4, 7 , HCA awards by EU’s Horizon 2020 program, the Genotype-Tissue Expression (GTEx) project 8 , the GenitoUrinary Developmental Molecular Anatomy Project (GUDMAP) 9 , Helmsley Charitable Trust: Gut Cell Atlas 3, 4, 7 , Human Tumor Atlas Network (HTAN) 10 , Human Biomolecular Atlas Program (HuBMAP) 11 , Kidney Precision Medicine Project [KPMP] 12 , LungMAP 13 , HCA grants from the United Kingdom Research and Innovation Medical Research Council (MRC) 14 , (Re)building the Kidney (RBK) 15 , Stimulating Peripheral Activity to Relieve Conditions (SPARC) 16 , The Cancer Genome Atlas (TGCA) 17–19 , and the Wellcome funding for HCA pilot projects HCA 3, 4, 7 . In total, over 2000 experts from around the globe are working together to construct an open, digital human reference atlas using a wide variety of single-cell methods, ranging from proteomics to antibody-based imaging methods as well as single-cell genomics and imaging.…”

Tissue Registration and Exploration User Interfaces in support of a Human Reference Atlas

“…The RUI requires about five minutes of training time and two minutes for each tissue registration 20 . As of December 2021, 404 tissue blocks and 6,178 tissue sections from the Human Biomolecular Atlas Program (HuBMAP) 3 , three biopsies from the Kidney Precision Medicine Project (KPMP) 21 , 26 heart tissue blocks from the Stimulating Peripheral Activity to Relieve Conditions (SPARC) 22 , 2,259 tissue blocks from the Genotype Tissue Expression project (GTEx) 23,24 , and six datasets from the Human Cell Atlas (HCA) 18,25,26 have been registered. The resulting data covers 11 organs; 376 distinct data files linked to 2,698 tissue blocks and their 6,178 tissue sections.…”