The human brain representation of odor identification

Kjelvik, Grete; Evensmoen, Hallvard Røe; Brezova, Veronika; Håberg, Asta

doi:10.1152/jn.01036.2010

Cited by 97 publications

(66 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, due to the heterogeneity of methods used across the studies the interpretation and comparison of results from these experiments is often difficult4567891011121314151617. Furthermore, many results support the idea that the neural correlates of odor processing are strongly task dependent, involving a distributed network of structures - even outside olfactory core regions - determined by the nature of the context and of the olfactory and sensory task17.…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge there is a noteworthy lack of investigation of olfaction neural correlates in resting-state by using FDG-PET/CT. In fact, in the majority of imaging studies the neural correlates of olfactory stimulation have been indirectly related to cerebral blood flow using techniques as fMRI and H 2 15 O-PET45678, being in the latter compulsory the presence of an in-house cyclotron along with a complicated and sensitive methodology.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Cortico-subcortical metabolic correlates of olfactory processing in healthy resting subjects

Alessandrini

Micarelli

Chiaravalloti

et al. 2014

Sci Rep

View full text Add to dashboard Cite

A wide network of interconnected areas was previously found in neuroimaging studies involving normal as well as pathological subjects; however literature seems to suffer from a lack of investigation in glucose metabolism behaviour under olfactory condition. Thus, the present work describe for the first time a pure olfactory related brain response of metabolism by using 18F-fluorodeoxyglucose-Positron Emission Tomography/Computer Tomography in eleven resting subjects undergoing a neutral and a pure olfactory condition. By contrasting these experimental phases, it was possible to depict a re-organization pattern of default mode network structures in a relatively ecological environment. Moreover, by correlating such pattern with a battery of validated olfactory and neuropsychological tests, our work allowed in showing peculiar correlation data that could cluster the subjects sample in a certain range of normality. We believe the present study could integrate the current knowledge in olfactory research and could be a start-up for future contributions.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Cortico-subcortical metabolic correlates of olfactory processing in healthy resting subjects

Alessandrini

Micarelli

Chiaravalloti

et al. 2014

Sci Rep

View full text Add to dashboard Cite

show abstract

“…This feedback originates from the same class of layer II/III neurons whose axons form the perforant path projection to the hippocampal formation (Agster and Burwell, 2009), whereas entorhinal cortex output to other, nonolfactory areas is predominantly from layer V pyramidal neurons. The LEC is responsive to objects (perhaps odorous) in an open field (Deshmukh and Knierim, 2011), and to odors (Boeijinga and Lopes da Silva, 1989;Eeckman and Freeman, 1990; Kay and Freeman, 1998; Chabaud et al, 2000; Kjelvik et al, 2012;Xu and Wilson, 2012) with singleunits more narrowly tuned than piriform cortical neurons (Xu and Wilson, 2012). Furthermore, local field potential analyses reveal that in odor discrimination-trained animals the EC can signal the OB before odor onset, potentially preparing the system for odor sampling (Kay et al, 1996;Martin et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Lateral Entorhinal Modulation of Piriform Cortical Activity and Fine Odor Discrimination

Chapuis

Cohen

et al. 2013

J. Neurosci.

View full text Add to dashboard Cite

The lateral entorhinal cortex (LEC) receives direct input from olfactory bulb mitral cells and piriform cortical pyramidal cells and is the gateway for olfactory input to the hippocampus. However, the LEC also projects back to the piriform cortex and olfactory bulb. Activity in the LEC is shaped by input from the perirhinal cortices, hippocampus, and amygdala, and thus could provide a rich contextual modulation of cortical odor processing. The present study further explored LEC feedback to anterior piriform cortex by examining how LEC top-down input modulates anterior piriform cortex odor evoked activity in rats. Retrograde viral tracing confirmed rich LEC projections to both the olfactory bulb and piriform cortices. In anesthetized rats, reversible lesions of the ipsilateral LEC increased anterior piriform cortical single-unit spontaneous activity. In awake animals performing an odor discrimination task, unilateral LEC reversible lesions enhanced ipsilateral piriform cortical local field potential oscillations during odor sampling, with minimal impact on contralateral activity. Bilateral LEC reversible lesions impaired discrimination performance on a well learned, difficult odor discrimination task, but had no impact on a well learned simple odor discrimination task. The simple discrimination task was impaired by bilateral reversible lesions of the anterior piriform cortex. Given the known function of LEC in working memory and multisensory integration, these results suggest it may serve as a powerful top-down modulator of olfactory cortical function and odor perception. Furthermore, the results provide potential insight into how neuropathology in the entorhinal cortex could contribute to early olfactory deficits seen in Alzheimer's disease.

show abstract

“…Furthermore, left OFC has been found to be activated in several olfactory tasks with specific response to odor identification (Qureshy et al, 2000), passive smelling (Kjelvik et al, 2012), odor discrimination (Plailly et al, 2007), mixture (Boyle et al, 2009), olfactory working memory (Dade et al, 2001), olfactory semantic association (Kareken et al, 2003) and familiarity to odors (Savic and Berglund, 2004). Therefore we may hypothesize, that our map 3, specifically evident in the processing of non-food odors, reflects all these characteristics of the odorant (lily of the valley) excluding the reward.…”

Section: Discussionmentioning

confidence: 89%

Source localization of event-related brain activity elicited by food and nonfood odors

Iannilli¹,

Sorokowska²,

Zhigang³

et al. 2015

Neuroscience

View full text Add to dashboard Cite

The human brain representation of odor identification

Abstract: Kjelvik G, Evensmoen HR, Brezova V, Håberg AK. The human brain representation of odor identification.

Cited by 97 publications

References 101 publications

Cortico-subcortical metabolic correlates of olfactory processing in healthy resting subjects

Cortico-subcortical metabolic correlates of olfactory processing in healthy resting subjects

Lateral Entorhinal Modulation of Piriform Cortical Activity and Fine Odor Discrimination

Source localization of event-related brain activity elicited by food and nonfood odors

Contact Info

Product

Resources

About