2004
DOI: 10.1016/j.micinf.2004.06.002
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The human and mouse orthologous LIM-only proteins respectively encoded in chromosome 6 and 17 show a different expression pattern

Abstract: Thymocytes interact with various subpopulations of thymic epithelial cells (TECs) at different stages of their development. To identify new molecules specifically expressed in TECs and/or thymic nurse cells (TNCs), we used representational difference analysis. We identified a LIM protein located on mouse chromosome 17 (m17TLP) and belonging to the family of the LIM-only proteins (LIMo). We found a new splice variant in addition to the two describedA and B isoforms. The three alternative species of m17TLP are f… Show more

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Cited by 2 publications
(3 citation statements)
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References 33 publications
(41 reference statements)
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“…Moreover, our findings suggest that it is highly recommended to perform systematic expression analyses in humans and mice before performing mechanistic mouse studies. Similar differences in the expression pattern of a protein in the human and murine organisms have been reported in a few previous studies, for example, for LIM-only proteins [31].…”
Section: Discussionsupporting
confidence: 83%
“…Moreover, our findings suggest that it is highly recommended to perform systematic expression analyses in humans and mice before performing mechanistic mouse studies. Similar differences in the expression pattern of a protein in the human and murine organisms have been reported in a few previous studies, for example, for LIM-only proteins [31].…”
Section: Discussionsupporting
confidence: 83%
“…Human CRIP3 could be detected in the fetal thymus, spleen, brain, heart, kidney, liver and lung partially in line with our observations (Casrouge et al, 2004). These limited findings make a comparison of the expression across species difficult.…”
Section: Bj-l)supporting
confidence: 88%
“…In adult mammals, all crip genes exhibit a wide tissue distribution, which might indicate essential roles in diverse cellular functions (Birkenmeier and Gordon, 1986, Casrouge et al, 2004, Chung et al, 2011, Karim et al, 1996, Kirchner et al, 2001, Levenson et al, 1993, Nalik et al, 1989, Okano et al, 1993, Tsui et al, 1994, van Ham et al, 2003, Wang et al, 1992, Yu et al, 2002. The different crip members have been linked to tissue differentiation and remodelling, immune response as well as suppression of angiogenesis and tumorigenesis (Chung et al, 2011, Davis et al, 1998, Lanningham-Foster et al, 2002, Wei et al, 2011.…”
mentioning
confidence: 99%