“…Initial work with a transgenic mouse model containing BPV-1 and HPV-5 and HPV-18 showed the development of skin lesions and viral amplification in situ in mice with BPV-1 genomes (Kondoh, Li et al, 1995; Hanahan, Wetzel et al, 1989). Several transgenic mouse models expressing HPV viral oncogenes in cutaneous tissues have also been studied extensively (Thomas, Pitot et al, 2011; Damian-Morales, Serafin-Higuera et al, 2016; Griep, Herber et al, 1993; Akgul, Pfefferle et al, 2006; Schaper, Marcuzzi et al, 2005). Important discoveries have accrued from these models on the impact of viral oncogenes in vivo, and at important anatomic sites such as the cervix and anal epithelium (Spurgeon, Chung et al, 2014; Thomas, Pitot et al, 2011).…”