The HOXC‐AS2/miR‐876‐5p/HKDC1 axis regulates endometrial cancer progression in a high glucose‐related tumor microenvironment

Guo, Jing; Ye, Feng; Xie, Wenli; Zhang, Xinxin; Zeng, Ru; Wang, Sheng; Mi, Yanjun; Sheng, Xiugui

doi:10.1111/cas.15384

Cited by 18 publications

(25 citation statements)

References 52 publications

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“…In vitro experiments showed that overexpression of DRAIR enhanced proliferation and viability of TNBC cells after doxorubicin treatment (99). Accumulated evidence dissected that lncRNA HOXC-AS2 participated in the progression in high glucose-related endometrial cancer (EC) (100). EC patients with diabetes had the increased expression of HKDC1 compared with EC patients with normal glucose.…”

Section: Lncrnas Regulate Glucose Metabolism In Cancermentioning

confidence: 99%

“…Accumulated evidence dissected that lncRNA HOXC-AS2 participated in the progression in high glucose-related endometrial cancer (EC) ( 100 ). EC patients with diabetes had the increased expression of HKDC1 compared with EC patients with normal glucose.…”

Section: Lncrnas Regulate Glucose Metabolism In Cancermentioning

confidence: 99%

“…EC patients with diabetes had the increased expression of HKDC1 compared with EC patients with normal glucose. HKDC1 governed pyroptosis, a highly inflammatory response of regulated cell death, via regulation of ROS and cytokine release in EC cells after high glucose stimulation ( 100 ). Moreover, miR-876-5p can inhibit the expression of HKDC1 in high glucose-related EC.…”

Section: Lncrnas Regulate Glucose Metabolism In Cancermentioning

confidence: 99%

“…Moreover, miR-876-5p can inhibit the expression of HKDC1 in high glucose-related EC. LncRNA HOXC-AS2 was dissected to suppress the miR-876-5p/HKDC1 axis in high glucose-associated EC ( 100 ). HKDC1 affected the formation of TME via promotion of glycolysis, leading to accelerating EC progression.…”

Section: Lncrnas Regulate Glucose Metabolism In Cancermentioning

confidence: 99%

“…HKDC1 affected the formation of TME via promotion of glycolysis, leading to accelerating EC progression. This work provided the new therapeutic strategy for EC patients with diabetes by targeting lncRNA HOXC-AS2 ( 100 ). LncRNA SNHG10 enhanced glucose uptake and increased proliferation of osteosarcoma cells via promotion of miR-218 methylation ( 101 ).…”

Section: Lncrnas Regulate Glucose Metabolism In Cancermentioning

confidence: 99%

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The role of lncRNAs in regulation of DKD and diabetes-related cancer

Cheng

Xia

et al. 2022

Front. Oncol.

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Diabetes mellitus often results in several complications, such as diabetic kidney disease (DKD) and end-stage renal diseases (ESRDs). Cancer patients often have the dysregulated glucose metabolism. Abnormal glucose metabolism can enhance the tumor malignant progression. Recently, lncRNAs have been reported to regulate the key proteins and signaling pathways in DKD development and progression and in cancer patients with diabetes. In this review article, we elaborate the evidence to support the function of lncRNAs in development of DKD and diabetes-associated cancer. Moreover, we envisage that lncRNAs could be diagnosis and prognosis biomarkers for DKD and cancer patients with diabetes. Furthermore, we delineated that targeting lncRNAs might be an alternative approach for treating DKD and cancer with dysregulated glucose metabolism.

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Section: Lncrnas Regulate Glucose Metabolism In Cancermentioning

confidence: 99%

Section: Lncrnas Regulate Glucose Metabolism In Cancermentioning

confidence: 99%

Section: Lncrnas Regulate Glucose Metabolism In Cancermentioning

confidence: 99%

Section: Lncrnas Regulate Glucose Metabolism In Cancermentioning

confidence: 99%

Section: Lncrnas Regulate Glucose Metabolism In Cancermentioning

confidence: 99%

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The role of lncRNAs in regulation of DKD and diabetes-related cancer

Cheng

Xia

et al. 2022

Front. Oncol.

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Pyroptosis and inflammasomes in cancer and inflammation

Wang,

Hua,

Bao

et al. 2023

MedComm

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Nonprogrammed cell death (NPCD) and programmed cell death (PCD) are two types of cell death. Cell death is significantly linked to tumor development, medication resistance, cancer recurrence, and metastatic dissemination. Therefore, a comprehensive understanding of cell death is essential for the treatment of cancer. Pyroptosis is a kind of PCD distinct from autophagy and apoptosis in terms of the structure and function of cells. The defining features of pyroptosis include the release of an inflammatory cascade reaction and the expulsion of lysosomes, inflammatory mediators, and other cellular substances from within the cell. Additionally, it displays variations in osmotic pressure both within and outside the cell. Pyroptosis, as evidenced by a growing body of research, is critical for controlling the development of inflammatory diseases and cancer. In this paper, we reviewed the current level of knowledge on the mechanism of pyroptosis and inflammasomes and their connection to cancer and inflammatory diseases. This article presents a theoretical framework for investigating the potential of therapeutic targets in cancer and inflammatory diseases, overcoming medication resistance, establishing nanomedicines associated with pyroptosis, and developing risk prediction models in refractory cancer. Given the link between pyroptosis and the emergence of cancer and inflammatory diseases, pyroptosis‐targeted treatments may be a cutting‐edge treatment strategy.

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CircVMP1 promotes glycolysis and disease progression by upregulating HKDC1 in colorectal cancer

Chen,

Li,

Yang

et al. 2023

Environmental Toxicology

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BackgroundCircular RNAs (circRNAs) have been reported to play important roles in cancers. Here, we characterized circVMP1 (hsa_circ_0006508), an important circRNA which promoted glycolysis and disease progression in colorectal cancer (CRC). In this study, we aimed to explore the mechanism by which circVMP1 regulated tumor glycolysis and its related pathways in promoting CRC cell proliferation and metastasis.MethodsThe expression level of circVMP1 in CRC tissues and adjacent normal tissues was detected using quantitative PCR. In vitro and in vivo functional experiments were used to evaluate the effects of circVMP1 in the regulation of CRC cell proliferation and migration. Mitochondrial stress tests and glycolysis stress tests were conducted to detect the effect of circVMP1 on oxidative phosphorylation and glycolysis. Dual‐luciferase reporter and RNA immunoprecipitation assays were used to evaluate the interaction between circVMP1, miR‐3167, and HKDC1.ResultsWe demonstrated that the level of circVMP1 was significantly upregulated in CRC tissues compared with normal tissues. In HCT116 and SW480 cells, overexpression of circVMP1 promoted proliferation, metastasis, and glycolysis. In vivo analysis indicated that circVMP1 accelerated the proliferation of xenograft tumors. As for the mechanism, overexpression of circVMP1 increased the levels of hexokinase domain component 1 (HKDC1) through competitive binding with miR‐3167.ConclusionOur study reported that circVMP1 was one of the tumor driver genes that promoted CRC malignant progression and glycolysis by upregulating HKDC1. CircVMP1/miR‐3167/HKDC1 was a signaling axis that might be a target for CRC therapy.

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The HOXC‐AS2/miR‐876‐5p/HKDC1 axis regulates endometrial cancer progression in a high glucose‐related tumor microenvironment

Cited by 18 publications

References 52 publications

The role of lncRNAs in regulation of DKD and diabetes-related cancer

The role of lncRNAs in regulation of DKD and diabetes-related cancer

Pyroptosis and inflammasomes in cancer and inflammation

CircVMP1 promotes glycolysis and disease progression by upregulating HKDC1 in colorectal cancer

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