Abstract:Trypanosoma brucei, a protozoan parasite transmitted by the tsetse fly, invades the bloodstream and CNS of humans, causing African sleeping sickness. In addition to antigenic variation of its surface glycoprotein coat, T. brucei employs a second immune evasion tactic: upregulation of endocytosis to clear lytic cell surface immune complexes, a strategy likely involving membrane turnover and fatty acid synthesis (FAS). Acetyl‐CoA carboxylase (ACC) catalyzes the first committed step of FAS and is a regulatory con… Show more
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