The Host Heat Shock Protein MRJ/DNAJB6 Modulates Virus Infection

Ko, Shih-Han; Huang, Li‐Min; Tarn, Woan‐Yuh

doi:10.3389/fmicb.2019.02885

Cited by 16 publications

(14 citation statements)

References 92 publications

(97 reference statements)

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“…In addition, heat shock proteins (HSPs) were upregulated in B. tabaci (MED) following TYLCV acquisition [ 48 ]. HSPs are reported to play a role in cell entry, replication and particle assembly, and movement in several animal viruses [ 135 ]. HSPs also are molecular chaperones responsible for cellular defense mechanisms against deleterious effects such as protein misfolding, degradation, and insoluble aggregation [ 136 ].…”

Section: Plant-virus-induced Responses In Vectorsmentioning

confidence: 99%

A Review on Transcriptional Responses of Interactions between Insect Vectors and Plant Viruses

Catto

Mugerwa

Myers

et al. 2022

Cells

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This review provides a synopsis of transcriptional responses pertaining to interactions between plant viruses and the insect vectors that transmit them in diverse modes. In the process, it attempts to catalog differential gene expression pertinent to virus–vector interactions in vectors such as virus reception, virus cell entry, virus tissue tropism, virus multiplication, and vector immune responses. Whiteflies, leafhoppers, planthoppers, and thrips are the main insect groups reviewed, along with aphids and leaf beetles. Much of the focus on gene expression pertinent to vector–virus interactions has centered around whole-body RNA extraction, whereas data on virus-induced tissue-specific gene expression in vectors is limited. This review compares transcriptional responses in different insect groups following the acquisition of non-persistent, semi-persistent, and persistent (non-propagative and propagative) plant viruses and identifies parallels and divergences in gene expression patterns. Understanding virus-induced changes in vectors at a transcriptional level can aid in the identification of candidate genes for targeting with RNAi and/or CRISPR editing in insect vectors for management approaches.

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Section: Plant-virus-induced Responses In Vectorsmentioning

confidence: 99%

A Review on Transcriptional Responses of Interactions between Insect Vectors and Plant Viruses

Catto

Mugerwa

Myers

et al. 2022

Cells

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“…Direct interaction in the DNAJB6 and prion protein during viral infection has been shown to favor nuclear localization of the HIV-1 pre integration complex. In addition, the delivery of primase-UL70 into cell nuclei through DNAJB6 may promote the synthesis of viral DNA during HCMV infection [ 40 ]. Although not all miRNA in the two circRNA networks selected in this study have binding with mRNA, they may be involved in CVB5 infection because they were the target molecules of circRNA.…”

Section: Discussionmentioning

confidence: 99%

Expression Profiles of Differentially Expressed Circular RNAs and circRNA–miRNA–mRNA Regulatory Networks in SH-SY5Y Cells Infected with Coxsackievirus B5

Yang

Shi

et al. 2022

International Journal of Genomics

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Coxsackievirus B5 (CVB5) is the causative agent of hand, foot, and mouth disease (HFMD) that can cause neurological complications and fatalities. Circular RNA (circRNA) has been shown to play an important role in regulating pathogenic processes. However, the functions of circRNA in response to CVB5 infection remain unclear. In our research, RNA-seq was employed to analyze the expression profiles of circRNAs in SH-SY5Y cells with or without CVB5 infection. Out of 5,665 circRNAs identified to be expressed in SH-SY5Y cells, 163 circRNAs were found to be differentially expressed significantly. Moreover, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses showed that the differentially expressed circRNAs were mainly involved in ubiquitin-mediated proteolysis and signaling pathways during CVB5 infection. Additionally, RT-qPCR was used to validate the RNA-seq data, and a circRNA–miRNA–mRNA interaction network was constructed based on two circRNAs, such as hsa_circ_0008378 and novel_circ_0014617, which were associated with the regulation of innate immune response in host cells. Additionally, we confirmed the two circRANs up-regulated the key factors in the IFN-I signaling pathway, hampering viral replication. Our data provide a new perspective that facilitates further understanding of the virus-host mechanism.

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“…Heat-shock proteins function as molecular chaperones to maintain proteostasis [113]. A number of viruses modulate the cellular heat-shock response or take advantage of cellular heat-shock proteins to overcome host environmental challenges and complete their life cycle [114,115]. An early study revealed that the human heat-shock protein DNAJB6 (also termed MRJ) is critical for nuclear import of the HIV-2 preintegration complex via its interaction with viral Vpx protein [116].…”

Section: The Heat-shock Protein Mrjmentioning

confidence: 99%

“…An early study revealed that the human heat-shock protein DNAJB6 (also termed MRJ) is critical for nuclear import of the HIV-2 preintegration complex via its interaction with viral Vpx protein [116]. Notably, MRJ has two splice isoforms that exert different effects on viral infection [115]. Isoform switching from the C-terminally truncated MRJ-S to full-length MRJ-L occurs during monocyte differentiation into macrophages, which are target cells for HIV [117].…”

Section: The Heat-shock Protein Mrjmentioning

confidence: 99%

Antisense Oligonucleotide-Based Therapy of Viral Infections

Tarn

Cheng

et al. 2021

Pharmaceutics

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Nucleic acid-based therapeutics have demonstrated their efficacy in the treatment of various diseases and vaccine development. Antisense oligonucleotide (ASO) technology exploits a single-strand short oligonucleotide to either cause target RNA degradation or sterically block the binding of cellular factors or machineries to the target RNA. Chemical modification or bioconjugation of ASOs can enhance both its pharmacokinetic and pharmacodynamic performance, and it enables customization for a specific clinical purpose. ASO-based therapies have been used for treatment of genetic disorders, cancer and viral infections. In particular, ASOs can be rapidly developed for newly emerging virus and their reemerging variants. This review discusses ASO modifications and delivery options as well as the design of antiviral ASOs. A better understanding of the viral life cycle and virus-host interactions as well as advances in oligonucleotide technology will benefit the development of ASO-based antiviral therapies.

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The Host Heat Shock Protein MRJ/DNAJB6 Modulates Virus Infection

Cited by 16 publications

References 92 publications

A Review on Transcriptional Responses of Interactions between Insect Vectors and Plant Viruses

A Review on Transcriptional Responses of Interactions between Insect Vectors and Plant Viruses

Expression Profiles of Differentially Expressed Circular RNAs and circRNA–miRNA–mRNA Regulatory Networks in SH-SY5Y Cells Infected with Coxsackievirus B5

Antisense Oligonucleotide-Based Therapy of Viral Infections

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