The hormone receptor, human epidermal growth factor receptor 2, and molecular subtype status of individual tumor foci in multifocal/multicentric invasive ductal carcinoma of breast

Choi, Yo Won; Kim, Eun Joo; Seol, Hyesil; Lee, Hee Eun; Jang, Mijung; Kim, Sun Mi; Kim, Jee Hyun; Kim, Sung Won; Choe, Gheeyoung; Park, So Yeon

doi:10.1016/j.humpath.2010.08.026

Cited by 59 publications

(50 citation statements)

References 29 publications

(29 reference statements)

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“…We and other authors have demonstrated that multiple breast carcinomas can differ among foci regarding histology and molecular profile (28,49,53). No studies however analyzing the impact of this heterogeneity on axillary metastases have been performed in multiple breast carcinomas.…”

Section: Molecular Profilementioning

confidence: 93%

“…A delimitation between MF and MC carcinomas was also attempted by using an arbitrary distance between tumor foci, for instance: <2 cm (MF) or >2 cm (MC) (9,23); >3 cm (MC) (10); <4 cm (MF) and >4 cm (MC) (3); <5 cm (MF) and >5 cm (MC) (8,17,18). In order to consider a tumor as MF, some authors recommend a minimum distance between foci: >1 mm (24), >4 mm (25,26), >5 mm (27,28). Some of these authors included both (in situ and invasive carcinomas) in their definitions, others only included invasive carcinomas.…”

Section: Definition and Terminologymentioning

confidence: 99%

“…However, not enough attention has been paid in the literature to the heterogeneity of multiple carcinoma foci. There are few studies that assessed histological and immunohistochemical features of tumor foci in multiple carcinomas, with contradictory results and variable conclusions (22,28,30,49,50,51). (Table 2) We aimed at analyzing all tumor foci from an immunohistochemical standpoint and at highlighting concordances or mismatches between them on a series of 806 cases (out of which 155 were multiple tumors) consecutively diagnosed with breast carcinoma between 2007-2012 in Tîrgu Mureş.…”

Section: Molecular Profilementioning

confidence: 99%

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Review on Practical Approach in Multiple Breast Carcinomas: Does Each Focus Matter?

Boros¹,

Georgescu²,

Podoleanu³

et al. 2017

chr

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RezumatCarcinomul mamar reprezintă cea mai frecventă tumoră malignă ce se dezvoltă la sexul feminin. De obicei, este o tumoră unică dar, uneori, poate fi multiplă. Datele din literatură cu privire la incidenţa, definiţia, profilul morfologic şi molecular, tratamentul şi prognosticul carcinoamelor mamare multiple sunt contradictorii, de aceea, acest articol prezintă o abordare practică pentru cei implicaţi în diagnosticul şi tratamentul unei astfel de leziuni care, poate prezenta heterogeneitate morfologică şi moleculară, acest lucru având un impact asupra managementului şi prognosticului. De aceea, este esenţial ca focarele tumorale multiple să se raporteze separat şi să fie luate în considerare în momentul unei decizii terapeutice.Cuvinte cheie: focare tumorale multiple, carcinom mamar Abstract Breast carcinoma is the most frequent form of cancer encountered in women worldwide. In the routine practice, most of breast carcinomas are diagnosed as unifocal, however, a variable proportion is represented by multiple tumor foci. Since data regarding the incidence, definition, morphological and molecular profile, treatment and

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Section: Molecular Profilementioning

confidence: 93%

Section: Definition and Terminologymentioning

confidence: 99%

Section: Molecular Profilementioning

confidence: 99%

See 1 more Smart Citation

Review on Practical Approach in Multiple Breast Carcinomas: Does Each Focus Matter?

Boros¹,

Georgescu²,

Podoleanu³

et al. 2017

chr

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“…We analyzed the largest invasive focus for molecular classification in multifocal breast cancers, because individual foci rarely vary in their molecular subtype. 29 The molecular phenotypes of tumors were determined according to the criteria of Nielsen et al modified as follows …”

Section: Diagnostic Criteriamentioning

confidence: 99%

Multifocal breast cancer documented in large‐format histology sections

Pekár

Hofmeyer

Tabár

et al. 2012

Cancer

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BACKGROUND:The prognostic significance of molecular phenotype in breast cancer is well established in the literature. Recent studies have demonstrated that subgross lesion distribution (unifocal, multifocal, and diffuse) and disease extent also carry prognostic significance in this disease. However, the correlation of molecular phenotypes with subgross parameters has not yet been investigated in detail. METHODS: In total, 444 consecutive invasive breast cancers that were documented in large-format histology slides and worked up with detailed radiologic-pathologic correlation were sampled into tissue microarray blocks and stained immunohistochemically to delineate the molecular subtypes. RESULTS: Diffuse or multifocal distribution of the invasive component of breast carcinomas in this series was associated with a 4.14-fold respectively 2.75-fold risk of cancer-related death compared with unifocal tumors irrespective of molecular phenotype. Patients who had human epidermal growth factor receptor 2 (HER2)-positive cancers; estrogen receptor-negative, progesterone receptor-negative, and HER2-negative (triple-negative) cancers; or basal-like cancers had a 2.18-fold, 2.33-fold, and 4.07-fold risk of dying of disease, respectively, compared with patients who had luminal A carcinomas. Unifocal luminal A, HER2-positive, and basal-like cancers were associated with significantly better long-term survival outcomes than their multifocal or diffuse counterparts; luminal B and triple-negative tumors also had the same tendency. In multivariate analysis, patient age, tumor size category, lymph node status, lesion distribution, and molecular phenotypes remained significant. CONCLUSIONS: Multifocality and diffuse distribution of the invasive component were associated with significantly poorer survival in women with breast carcinomas compared with unifocal disease in patients with luminal A, HER2 type, and basal-like cancers. Molecular classification of breast cancer is a powerful tool but gains in power when combined with conventional and subgross morphologic parameters. Cancer 2013;119:1132-9. V C 2012 American Cancer Society.KEYWORDS: breast, breast cancer, multifocality, diffuse, molecular phenotypes, survival. INTRODUCTIONBreast cancer mortality has decreased significantly in countries that have organized, population-based mammography screening 1 ; however, despite using the most recent diagnostic tools and modern therapeutic regimens, women are still dying from this disease. Therefore, exploring the prognostic information generated by radiologic, histologic, and molecular tumor characteristics is essential to facilitate individualized treatment and further decrease disease-specific mortality.Patient age, tumor size, histologic grade, and lymph node status still remain powerful prognostic indicators in patients with breast cancer.2,3 On the other hand, many second-generation prognostic parameters have emerged and have been introduced into routine practice, and the most prominent are estrogen receptor (ER), progesterone recepto...

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“…There is a positive correlation between the presence of axillary lymph node metastases and the number of tumour foci [4,5]. In multiple carcinomas, between 3% and 37.5% of cases may have different histological tumour types and/or histological grades (inter-tumour heterogeneity) [3,[6][7][8][9][10]. This is related to shorter survival and may influence the choice of therapy [6].…”

Section: Introductionmentioning

confidence: 99%

Original paper Multifocal/multicentric breast carcinomas showing intertumoural heterogeneity: a comparison of histological tumour type and Nottingham histological grade of primary tumour and lymph node metastasis

Boros¹,

Podoleanu²,

Georgescu³

et al. 2015

pjp

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The hormone receptor, human epidermal growth factor receptor 2, and molecular subtype status of individual tumor foci in multifocal/multicentric invasive ductal carcinoma of breast

Cited by 59 publications

References 29 publications

Review on Practical Approach in Multiple Breast Carcinomas: Does Each Focus Matter?

Review on Practical Approach in Multiple Breast Carcinomas: Does Each Focus Matter?

Multifocal breast cancer documented in large‐format histology sections

Original paper Multifocal/multicentric breast carcinomas showing intertumoural heterogeneity: a comparison of histological tumour type and Nottingham histological grade of primary tumour and lymph node metastasis

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