The hormonal response of older men to sub-maximum aerobic exercise: The effect of training and detraining

Lovell, Dale I.; Cuneo, Ross C.; Wallace, Jennifer D.; McLellan, Chris

doi:10.1016/j.steroids.2011.12.022

Cited by 45 publications

(52 citation statements)

References 36 publications

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“…Similar to the findings of the present investigation, SHBG also increased although to a lesser extent than in the present study, which resulted in a small but statistically change in free-T. In contrast, Lovell et al [21] reported exercise (resistance or aerobic) training performed three times per week over 16 weeks did not increase resting TT or free-T in older men. There are few comparable studies on the sex hormone response to exercise in aging men.…”

Section: Resultssupporting

confidence: 86%

“…Khoo et al [18] reported small but significant increase in free-T which was not the case in the present study. In contrast, Lovell et al [21] found no change to TT, SHBG or free-T in an older cohort than the present study (~74 years) but critically, this cohort were already moderately active rather than the sedentary cohort of the present study and that of Khoo et al [18]. Taken together, this suggests participants training status may affect outcomes of subsequent exercise training interventions.…”

Section: Resultscontrasting

confidence: 86%

“…However, it is unclear whether this represents a long term effect of exercise training on maintaining TT or whether those who sustain serum TT into old age (pro-androgenic phenotype) are also more able to undertake the rigours of exercise. Indeed, such observations are not consistent with similar investigations that demonstrate TT to be unaffected by exercise training in aging cohorts [21][22][23], and more recently in lifelong sedentary, but otherwise healthy, aging men [24].…”

Section: Introductioncontrasting

confidence: 61%

“…Experimental studies have conveyed that individuals embarking on an exercise program from middle to older age typically experience improvements in CRF [21,25,26] in addition to improved muscle strength [21,27] and power [28]. Modest increases in CRF are associated with lower mortality risk [29], such that one metabolic equivalent (MET) increase in peak oxygen uptake (V O [an increment achievable by most sedentary individuals, healthy or otherwise]) can produce considerable (10%-25%) improvement in survival [30].…”

Section: Introductionmentioning

confidence: 99%

“…It is unclear whether the decline in sex steroid hormones with advancing age is due to biological aging per se or a secondary consequence of lifestyle changes such as reduced physical activity [21]. Cross-sectional studies have observed a positive correlation between physical fitness and serum T in older men [31,32].…”

Section: Introductionmentioning

confidence: 99%

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Six weeks of conditioning exercise increases total, but not free testosterone in lifelong sedentary aging men

et al. 2015

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, Fergal M. (2015) Six weeks of conditioning exercise increases total, but not free testosterone in lifelong sedentary aging men. Aging Male, Downloaded from: http://insight.cumbria.ac.uk/1832/ Usage of any items from the University of Cumbria's institutional repository 'Insight' must conform to the following fair usage guidelines.Any item and its associated metadata held in the University of Cumbria's institutional repository Insight (unless stated otherwise on the metadata record) may be copied, displayed or performed, and stored in line with the JISC fair dealing guidelines (available here) for educational and not-for-profit activities provided that• the authors, title and full bibliographic details of the item are cited clearly when any part of the work is referred to verbally or in the written form• a hyperlink/URL to the original Insight record of that item is included in any citations of the work • the content is not changed in any way• all files required for usage of the item are kept together with the main item file. You may not• sell any part of an item• refer to any part of an item without citation • amend any item or contextualise it in a way that will impugn the creator's reputation• remove or alter the copyright statement on an item. AbstractIntroduction: Advancing age is associated with a gradual decline in circulating androgens and the putative role of exercise training on systemic androgens remain to be adequately defined. Results: Analysis of variance (ANOVA) revealed a lack of significant change in any parameter amongst LE whilst SED experienced a significant exercise-induced improvement in cardiorespiratory fitness, and total testosterone (all p<0.05). Concurrent increases in sex hormone-binding globulin (SHBG; p<0.05) resulted in a lack of change to either bioavailable or calculated free testosterone (p>0.05) amongst SED. MethodsConclusions: Although resting levels of systemic total testosterone increased in response to six weeks of exercise training, increases in SHBG negated any potential relationship between calculated-free or bioavailable testosterone. These findings indicate that increases in bioavailable testosterone fraction are not required for cardiorespiratory fitness improvements in aging men.

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Section: Resultssupporting

confidence: 86%