The hormonal regulation of cutaneous wound healing

Gilliver, Stephen C.; Ashworth, Jason J.; Ashcroft, Gillian S.

doi:10.1016/j.clindermatol.2006.09.012

Cited by 165 publications

(101 citation statements)

References 49 publications

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“…In addition, in vitro E 2 administration increased human RPE cell MMP-2 activity (Marin-Castano et al, 2003). Estrogens regulate MMP-2 activity not only in RPE cells, but multiple other cell types such as smooth muscle cells, glomerular mesangial cells and skin fibroblasts (Gilliver et al, 2007;Karl et al, 2006;Marin-Castano et al, 2003;Wingrove et al, 1998). Therefore our goal in this study was to determine whether estrogen can prevent oxidant injury induced ECM dysregulation.…”

Section: Discussionmentioning

confidence: 99%

Subtype specific estrogen receptor action protects against changes in MMP-2 activation in mouse retinal pigmented epithelial cells

Elliot

Catanuto

Fernández

et al. 2008

Experimental Eye Research

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Eyes with age-related macular degeneration (AMD) demonstrate accumulation of specific deposits and extracellular matrix (ECM) molecules under the retinal pigment epithelium (RPE). AMD is about two times more prevalent in aging postmenopausal women. Therefore we studied whether 17β-estradiol (E 2 ) modulates the expression and activity of the trimolecular complex (MMP-2, TIMP-2 and MMP-14), molecules which are of major importance for ECM turnover in RPE. We used cell lines isolated from estrogen receptor knockout mice (ERKO) to determine which ER (estrogen receptor) subtype was important for ECM regulation in RPE cells.We found that mouse RPE sheets had higher baseline MMP-2 activity in the presence of ERβ. This correlated with higher MMP-2 activity in RPE cell lines isolated from ERKOα mice. Exposure to E 2 increased MMP-2 activity in mouse RPE cell lines. In addition E 2 increased transcriptional activation of the MMP-2 promoter through a functional Sp1 site which required the presence of ERβ, but not ERα. E 2 also maintained levels of pro MMP-2, and MMP-14 and TIMP-2 activity after oxidant injury. Since the direct effects of E 2 on MMP-2 transcriptional activation and the regulation of the trimolecular complex after oxidant induced injury requires ERβ, this receptor subtype may have a role as a potential therapeutic target to prevent changes in activation of MMP-2.

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Section: Discussionmentioning

confidence: 99%

Subtype specific estrogen receptor action protects against changes in MMP-2 activation in mouse retinal pigmented epithelial cells

Elliot

Catanuto

Fernández

et al. 2008

Experimental Eye Research

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“…In several species, testosterone has been proposed to mediate the tradeoff between reproductive effort, survival, and immune function (17,61). Indeed there is strong evidence from laboratory-based studies that testosterone suppresses aspects of immune function, including wound healing (62). Wild studies also support the immunosuppressive effects of testosterone, but the results vary 8; n = 380), the gray line indicates injuries and illnesses in low-ranking males (ranks lower than 8; n = 68).…”

Section: Discussionmentioning

confidence: 99%

Social status predicts wound healing in wild baboons

Archie

Altmann

Alberts

2012

Proc. Natl. Acad. Sci. U.S.A.

137

138

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Social status can have striking effects on health in humans and other animals, but the causes often are unknown. In male vertebrates, status-related differences in health may be influenced by correlates of male social status that suppress immune responses. Immunosuppressive correlates of low social status may include chronic social stress, poor physical condition, and old age; the immunosuppressive correlates of high status may include high testosterone and energetic costs of reproduction. Here we test whether these correlates could create status-related differences in immune function by measuring the incidence of illness and injury and then examining healing rates in a 27-y data set of natural injuries and illnesses in wild baboon males. We found no evidence that the high testosterone and intense reproductive effort associated with high rank suppress immune responses. Instead, high-ranking males were less likely to become ill, and they recovered more quickly than low-ranking males, even controlling for differences in age. Notably, alpha males, who experience high glucocorticoids, as well as the highest testosterone and reproductive effort, healed significantly faster than other males, even other high-ranking males. We discuss why alpha males seem to escape from the immunosuppressive costs of glucocorticoids but low-ranking males do not, including the idea that glucocorticoids' effects depend on an individual's physiological and social context.

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“…Random intercept mixed regression analyses were performed for all outcome measures. Sex was included as factor, as it is known that men and women exhibit distinct physiological properties of the skin (Gilliver et al 2007). We started testing saturated models including all predictors and their interactions and continued with stepwise exclusion of non-significant interaction terms.…”

Section: Discussionmentioning

confidence: 99%

The effect of Mindfulness-Based Stress Reduction on wound healing: a preliminary study

et al. 2017

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Psychological factors have been shown to influence the process of wound healing. This study examined the effect of Mindfulness-Based Stress Reduction (MBSR) on the speed of wound healing. The local production of pro-inflammatory cytokines and growth factors was studied as potential underlying mechanism. Forty-nine adults were randomly allocated to a waiting-list control group (n = 26) or an 8-week MBSR group (n = 23). Preand post-intervention/waiting period assessment for both groups consisted of questionnaires. Standardized skin wounds were induced on the forearm using a suction blister method. Primary outcomes were skin permeability and reduction in wound size monitored once a day at day 3, 4, 5, 6, 7, and 10 after injury. Secondary outcomes were cytokines and growth factors and were measured in wound exudates obtained at 3, 6, and 22 h after wounding. Although there was no overall condition effect on skin permeability or wound size, post hoc analyses indicated that larger increases in mindfulness were related to greater reductions in skin permeability 3 and 4 days after wound induction. In addition, MBSR was associated with lower levels of interleukin (IL)-8 and placental growth factor in the wound fluid 22 h after wound induction. These outcomes suggest that increasing mindfulness by MBSR might

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The hormonal regulation of cutaneous wound healing

Cited by 165 publications

References 49 publications

Subtype specific estrogen receptor action protects against changes in MMP-2 activation in mouse retinal pigmented epithelial cells

Subtype specific estrogen receptor action protects against changes in MMP-2 activation in mouse retinal pigmented epithelial cells

Social status predicts wound healing in wild baboons

The effect of Mindfulness-Based Stress Reduction on wound healing: a preliminary study

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