The hormesis database: The occurrence of hormetic dose responses in the toxicological literature

Calabrese, Edward J.; Blain, Robyn

doi:10.1016/j.yrtph.2011.06.003

Cited by 339 publications

(202 citation statements)

References 12 publications

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“…This governmental force-fed model, which has never been validated, is in conflict with a plethora of well-established adaptive mechanisms discovered after the incorporation of the LNT default model into risk assessment (9) and is inconsistent with a vast and expanding toxicological literature for chemicals and ionizing radiation (13) that disputes the accuracy of predictions based on the LNT.…”

Section: Commentarymentioning

confidence: 95%

Improving the scientific foundations for estimating health risks from the Fukushima incident

Calabrese

2011

Proc. Natl. Acad. Sci. U.S.A.

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Section: Commentarymentioning

confidence: 95%

Improving the scientific foundations for estimating health risks from the Fukushima incident

Calabrese

2011

Proc. Natl. Acad. Sci. U.S.A.

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“…Referidos resultados estão de acordo com a afirmação de que a resposta máxima da hormese normalmente é modesta e que diferentes parâmetros podem ser afetados em diferentes concentrações (Calabrese & Blain, 2011 O efeito hormético em minhocas do gênero Eisenia também foi documentado para a enzima acetilcolinesterase durante a exposição ao inseticida organofosforado temefós (Hackenberger et al, 2008).…”

Section: Methodsunclassified

“…O fenômeno da hormese está relacionado, provavelmente, com a ativação de vias metabólicas adaptativas, responsáveis pela homeostase celular e fisiológica (Calabrese & Blain, 2011). Desta forma, o efeito hormético detectado para a enzima fosfatase alcalina pode explicar, em parte, o efeito observado para o parâmetro taxa de desenvolvimento visto que enzimas Figura 2.…”

Section: Methodsunclassified

“…A hormese é um conceito toxicológico que se refere a uma dose-resposta bifásica (não monotônica) a um agente ambiental e que é caracterizada pela estimulação em baixas concentrações e uma inibição em concentrações elevadas (Calabrese & Blain, 2011). Entretanto, a detecção correta e a estimação deste efeito dependem da aplicação de modelos estatísticos adequados (Deng et al, 2001;Zhu et al, 2013).…”

Section: Introductionunclassified

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Indução de ivermectina na hormese sobre Eisenia foetida durante a vermicompostagem de esterco bovino

Tuerlinckx

Morselli

Huber

2015

Rev. bras. eng. agríc. ambient.

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R E S U M OOs medicamentos veterinários são, em sua maioria, excretados nas fezes de animais tratados demonstrando que os fármacos da classe das avermectinas podem ter efeitos nocivos sobre os organismos não alvo, caso se utilizem das fezes. O objetivo deste estudo foi determinar os efeitos subletais da ivermectina sobre as minhocas Eisenia foetida expostas às concentrações de ivermectina a 0, 1, 5, 10, 50 e 100 mg kg -1 ; amostras foram tomadas nos dias 7, 14 e 28 de exposição para determinação da sobrevivência, crescimento, produção de casulos e atividades enzimáticas, além de estudadas as alterações químicas e a atividade microbiana do vermicomposto não se observando, no entanto, efeitos negativos da ivermectina quanto à mortalidade de minhocas; da mesma forma, as características químicas e a atividade microbiana do vermicomposto não foram afetadas porém os resultados demonstraram que a ivermectina induz, quando em baixas concentrações, a um aumento na atividade da fosfatase alcalina e no crescimento de E. foetida mas altas concentrações inibiram esses parâmetros, o que foi refletido numa curva em forma de U invertido, uma representação gráfica do efeito hormético.Induction of ivermectin in the hormesis on Eisenia foetida during the vermicomposting of cattle manure A B S T R A C TMost of the veterinary pharmaceuticals are excreted in the faeces of treated animals and it has been demonstrated that members of the avermectin group may have deleterious effects on non-target organisms utilising the faeces. The aim of this study is to determine the sublethal effects of ivermectin on the Eisenia foetida earthworms. Earthworms were exposed to ivermectin at 0, 1, 5, 10, 50 and 100 mg kg -1 concentrations; samples were taken at 7, 14, and 28 days exposure for determination of survival, growth rate, cocoon production and enzyme activities. Furthermore, the chemical changes and microbial activity of the vermicompost were also studied. There was no negative effects of ivermectin on mortality of earthworms. Likewise the chemical characteristics and microbial activity of vermicompost were not affected. However, the results showed that ivermectin at low concentrations induces an increase in the activity of alkaline phosphatase and growth of E. foetida, but high concentrations inhibited these endpoints, and this was reflected in an inverted U-shaped curve, a graphic representation of hormetic effect. Palavras-chave:efeito hormético fármacos veterinários minhocas toxicidade Key words: earthworms hormetic effect toxicity veterinary pharmaceuticals

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“…Mild stressors such as sub-lethal ischemic episodes and PI are also known as hormetic stimuli. Hormesis is defined as favorable reactions to low-level stress and has been observed in the toxicological literature for many decades (4)(5)(6)(7)47). Hormesis elicits U-shaped or biphasic responses to stress and is mediated, at least in part, by the co-ordinated network of vitagenes (8)(9)(10)20).…”

Section: Ape1 Preserves Neuronal Structure and Functionmentioning

confidence: 99%

Apurinic/Apyrimidinic Endonuclease 1 Upregulation Reduces Oxidative DNA Damage and Protects Hippocampal Neurons from Ischemic Injury

Leak

Li²,

Zhang³

et al. 2015

Antioxidants & Redox Signaling

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Aims: Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional enzyme that participates in base-excision repair of oxidative DNA damage and in the redox activation of transcription factors. We tested the hypothesis that APE1 upregulation protects neuronal structure and function against transient global cerebral ischemia (tGCI). Results: Upregulation of APE1 by low-dose proton irradiation (PI) or by transgene overexpression protected hippocampal CA1 neurons against tGCI-induced cell loss and reduced apurinic/apyrimidinic sites and DNA fragmentation. Conversely, APE1 knockdown attenuated the protection afforded by PI and ischemic preconditioning. APE1 overexpression inhibited the DNA damage response, as evidenced by lower phospho-histone H2A and p53-upregulated modulator of apoptosis levels. APE1 overexpression also partially rescued dendritic spines and attenuated the decrease in field excitatory postsynaptic potentials in hippocampal CA1. Presynaptic and postsynaptic markers were reduced after tGCI, and this effect was blunted in APE1 transgenics. The Morris water maze test revealed that APE1 protected against learning and memory deficits for at least 27 days post-injury. Animals expressing DNA repair-disabled mutant APE1 (D210A) exhibited more DNA damage than wild-type controls and were not protected against tGCI-induced cell loss. Innovation: This is the first study that thoroughly characterizes structural and functional protection against ischemia after APE1 upregulation by measuring synaptic markers, electrophysiological function, and long-term neurological deficits in vivo. Furthermore, disabling the DNA repair activity of APE1 was found to abrogate its protective impact. Conclusion: APE1 upregulation, either endogenously or through transgene overexpression, protects DNA, neuronal structures, synaptic function, and behavioral output from ischemic injury. Antioxid. Redox Signal. 22,[135][136][137][138][139][140][141][142][143][144][145][146][147][148]

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The hormesis database: The occurrence of hormetic dose responses in the toxicological literature

Cited by 339 publications

References 12 publications

Improving the scientific foundations for estimating health risks from the Fukushima incident

Improving the scientific foundations for estimating health risks from the Fukushima incident

Indução de ivermectina na hormese sobre Eisenia foetida durante a vermicompostagem de esterco bovino

Apurinic/Apyrimidinic Endonuclease 1 Upregulation Reduces Oxidative DNA Damage and Protects Hippocampal Neurons from Ischemic Injury

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