2004
DOI: 10.1002/ddr.10360
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The homocysteine pathway: A new target for Alzheimer disease treatment?

Abstract: One of the known risk factors for developing Alzheimer disease (AD) is hyperhomocysteinemia. The latter may result from mutations of the genes coding for three key enzymes involved in homocysteine metabolism (methylenetetrahydrofolate reductase [MTHFR], methionine synthase [MS], and cystathionine beta-synthase [CBS]). Polymorphisms within the three genes have been shown to be positively associated with AD in some populations. Whereas MS and MTHFR polymorphisms have been described as AD risk factors independent… Show more

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Cited by 4 publications
(2 citation statements)
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“…The ligating power of Hcys has been explored. Hcys is a biologically active thioamino acid, considered as the biomarker of oxidative stress which is also involved in cardiovascular disease, kidney failure, and other diseases. The MB responses to Hg 2+ and Hcys have been analyzed on the basis of the proposed model of reversible MB interactions which enabled the determination of the conditional formation constant K THgT and the Gibbs free energy for T–Hg–T bridge formation. The model parameters, including the formation constants for Hcys complexes of Hg 2+ , have been determined from fluorimetric measurements of MB ON/OF switching and results of 1 H NMR spectral analysis.…”
mentioning
confidence: 99%
“…The ligating power of Hcys has been explored. Hcys is a biologically active thioamino acid, considered as the biomarker of oxidative stress which is also involved in cardiovascular disease, kidney failure, and other diseases. The MB responses to Hg 2+ and Hcys have been analyzed on the basis of the proposed model of reversible MB interactions which enabled the determination of the conditional formation constant K THgT and the Gibbs free energy for T–Hg–T bridge formation. The model parameters, including the formation constants for Hcys complexes of Hg 2+ , have been determined from fluorimetric measurements of MB ON/OF switching and results of 1 H NMR spectral analysis.…”
mentioning
confidence: 99%
“…It has become clear that elevated levels of Hcy elicit neuronal death, including hippocampal and cortical neurons. 1,3 Cross-sectional magnetic resonance imaging (MRI) studies describe a similar correlation between high Hcy levels and cerebral atrophy. The increased level of tHcy predicts the rate of shrinkage of the medial temporal lobe in patients with AD.…”
Section: Introductionmentioning
confidence: 97%