The homeobox HOXB13 is expressed in human minor salivary gland

Cazal, Cláudia; Sobral, Apv; Almeida, Fcs De; Silva‐Valenzuela, Maria das Graças da; Durazzo,; Nunes, Fábio Daumas

doi:10.1111/j.1601-0825.2005.01218.x

Cited by 10 publications

(5 citation statements)

References 9 publications

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“…In contrast to mouse development (Zeltser et al, 1996; Cillo et al, 2001) where spatial expression of Hoxb13 along the primary axis in hindgut, urogenital tract, and posterior extent of the spinal cord was reported, no HOXB13 mRNA was observed in human abdominopelvic organs. HOXB13 expression was detected in the epithelia of the developing trachea and esophagus in our study, and in proliferating fibroblasts of the fetal dermis by Stelnicki et al (1998) and by Cazal and colleagues (2006) in human minor salivary glands. However, a recent study concerning germ‐line mutations in HOXB13 and an associated higher prostate‐cancer risk (Ewing et al, 2012) suggests a potential involvement of HOXB13 in developmental stages not investigated here.…”

Section: Discussionsupporting

confidence: 79%

Spatio‐temporal expression of HOX genes in human hindgut development

Illig

Fritsch

Schwarzer

2012

Developmental Dynamics

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Background: Hox genes belong to a highly conserved subgroup of the homeobox gene superfamily. Studies of animal models have emphasized their role in defining the body plan by their coordinated expression along the body axis during ontogeny. Although an important role of HOX genes in human development is assumed, little is known about their expression during human ontogenesis. Therefore, we investigated the expression of the nine most posterior members of the HOXA, HOXB, HOXC, and HOXD clusters in embryonic hindgut between weeks 6 to 12 and in adult rectal tissue. Results: Applying in situ hybridization and immunohistochemistry, we observed expression of HOXA11, HOXA13, HOXD12, and HOXD13 in developmental week 6. However, expression of HOXD12 faded during weeks 7 and 8, and then became increasingly re-expressed during week 9 in humans. With the exception of HOXD13, all expressed HOX genes dropped below detection limits in week 11. Adult rectal tissue displayed distinct HOXA11, HOXA13, HOXD12, and HOXD13 expression patterns within the rectal layers. Conclusions: Our data suggest a strict spatio-temporal regulation of HOX gene expression during human development, supporting the idea of their role as key regulators. Nonetheless, the expression pattern of distinct HOX genes differs markedly from animal models. Developmental Dynamics 242:53-66, 2013. V C 2012 Wiley Periodicals, Inc.Key words: HOX gene expression; hindgut; developmental regulation Key findings:Distinct spatio-temporal expression of HOX genes in human ontogeny. Same HOX genes expressed in adult human rectum. Marked differences between human development and animal models.

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Section: Discussionsupporting

confidence: 79%

Spatio‐temporal expression of HOX genes in human hindgut development

Illig

Fritsch

Schwarzer

2012

Developmental Dynamics

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“…In addition, it is significantly correlated with VEGF expression and microvessels density, suggesting a central role of HOXB13 in HCC angiogenesis and tumor progression [116]. Finally, an altered HOXB13 expression has been described in oral cancers [117,118] and glioma patients [119].…”

Section: Hoxb13mentioning

confidence: 99%

Paralogous HOX13 Genes in Human Cancers

Botti

Cillo

Cecio

et al. 2019

Cancers

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Hox genes (HOX in humans), an evolutionary preserved gene family, are key determinants of embryonic development and cell memory gene program. Hox genes are organized in four clusters on four chromosomal loci aligned in 13 paralogous groups based on sequence homology (Hox gene network). During development Hox genes are transcribed, according to the rule of “spatio-temporal collinearity”, with early regulators of anterior body regions located at the 3’ end of each Hox cluster and the later regulators of posterior body regions placed at the distal 5’ end. The onset of 3’ Hox gene activation is determined by Wingless-type MMTV integration site family (Wnt) signaling, whereas 5’ Hox activation is due to paralogous group 13 genes, which act as posterior-inhibitors of more anterior Hox proteins (posterior prevalence). Deregulation of HOX genes is associated with developmental abnormalities and different human diseases. Paralogous HOX13 genes (HOX A13, HOX B13, HOX C13 and HOX D13) also play a relevant role in tumor development and progression. In this review, we will discuss the role of paralogous HOX13 genes regarding their regulatory mechanisms during carcinogenesis and tumor progression and their use as biomarkers for cancer diagnosis and treatment.

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“…In particular it was largely investigated the role of HOX B13 in tumor progression [16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Deregulation of HOX B13 Expression in Urinary Bladder Cancer Progression

Cantile¹,

Scognamiglio²,

Marra³

et al. 2013

Current Medicinal Chemistry

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Urinary bladder cancer is a common malignancy in industrialized countries. More than 90% of bladder cancer originates in the transitional cells. Bladder transitional cancer prognosis is, according to the most recent definition related to the level of tumor infiltration, characterized by two main phenotypes, Non Muscle Invasive Bladder Transitional Cancer (NMIBC) and Muscle Invasive Bladder Transitional Cancer (MIBC). The genetic profile and the clinical course of the two subtypes are completely different, however among NMIBC the prognosis is not completely predictable, since 20% of the cases experience a relapse, even in the form of MIBC. It has recently been reported that the chromosomal region 12q13-15, containing crucial cancer genes such as MDM2, CDK4, GLI and an entire cluster of HOX genes, is amplified in bladder cancer. HOX genes codify for transcriptionl factor, involved in embryonal development and cancer progression, with main nuclear expression. Particularly it was also described the strong involvement of HOX B13 in several tumors of urogenital system. In this study we have been investigated, by immunohistochemisty and quantitative Real Time PCR, the HOX B13 expression in bladder cancer evolution and progression, evaluating its ability to discriminate between NMIBC and MBCI phenotypes. Cytoplasmic HOX B13 delocalization significantly relates with muscle invasion (p 0.004). In addition in the series of NMIBC nuclear HOX B13 expression loss is significantly associated to shorter disease free survival (p-value=0.038) defining a potential prognostic role. Overexpression of HOX B13 in more aggressive phenotype is also demonstrate at gene level by quantitative RT-PCR. The de-regulation and delocalization of HOX B13 in urinary bladder cancer supports again the important role of HOX genes in tumor evolution and represents a starting point to establish an integrated analysis, in which HOX genes represent important prognostic and predictive markers for bladder cancer.

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The homeobox HOXB13 is expressed in human minor salivary gland

Abstract: RESULTS suggest that HOXB13 transcripts are differently expressed in normal mucous and serous acini, and it may possibly reflect a different role in salivary gland carcinogenesis.

Cited by 10 publications

References 9 publications

Spatio‐temporal expression of HOX genes in human hindgut development

Spatio‐temporal expression of HOX genes in human hindgut development

Paralogous HOX13 Genes in Human Cancers

Deregulation of HOX B13 Expression in Urinary Bladder Cancer Progression

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