The Hmong Diaspora: Preserved South-East Asian genetic ancestry in French Guianese Asians

Brucato, Nicolas; Mazières, Stéphane; Guitard, Evelyne; Giscard, Pierre-Henri; Bois, E; Larrouy, Georges; Dugoujon, Jean‐Michel

doi:10.1016/j.crvi.2012.10.003

Cited by 7 publications

(9 citation statements)

References 51 publications

(77 reference statements)

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“…Eleven O3 lineages, out of the 19 described by Karafet et al [8,26,39] were observed in this study (Figure 2 and Additional file 1: Table S2). The most widely distributed sub-haplogroups of O3 in our dataset are O3a1c*-IMS-JST002611, O3a2*-P201, O3a2b*-M7 and O3a2c*-P164.…”

Section: Resultsmentioning

confidence: 61%

“…Maps are based on data from Additional file 1: Tables S1 and S2 and from literature data [12,27,30,36,39,40,62]. Panels are labeled according to ISOGG2011 [8,42,43].…”

Section: Resultsmentioning

confidence: 99%

“…Comparative data with other populations of south China, ISEA and Oceania were taken from the literature and comprised Yueh/Daic-speaking populations [27,30,36-38], Malayo-Polynesians and Papua New Guineans [39], and Han Chinese [7,8,12,29,30,40,41]. These datasets are shown in Additional file 1: Table S1.…”

Section: Methodsmentioning

confidence: 99%

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Taiwan Y-chromosomal DNA variation and its relationship with Island Southeast Asia

et al. 2014

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BackgroundMuch of the data resolution of the haploid non-recombining Y chromosome (NRY) haplogroup O in East Asia are still rudimentary and could be an explanatory factor for current debates on the settlement history of Island Southeast Asia (ISEA). Here, 81 slowly evolving markers (mostly SNPs) and 17 Y-chromosomal short tandem repeats were used to achieve higher level molecular resolution. Our aim is to investigate if the distribution of NRY DNA variation in Taiwan and ISEA is consistent with a single pre-Neolithic expansion scenario from Southeast China to all ISEA, or if it better fits an expansion model from Taiwan (the OOT model), or whether a more complex history of settlement and dispersals throughout ISEA should be envisioned.ResultsWe examined DNA samples from 1658 individuals from Vietnam, Thailand, Fujian, Taiwan (Han, plain tribes and 14 indigenous groups), the Philippines and Indonesia. While haplogroups O1a*-M119, O1a1*-P203, O1a2-M50 and O3a2-P201 follow a decreasing cline from Taiwan towards Western Indonesia, O2a1-M95/M88, O3a*-M324, O3a1c-IMS-JST002611 and O3a2c1a-M133 decline northward from Western Indonesia towards Taiwan. Compared to the Taiwan plain tribe minority groups the Taiwanese Austronesian speaking groups show little genetic paternal contribution from Han. They are also characterized by low Y-chromosome diversity, thus testifying for fast drift in these populations. However, in contrast to data provided from other regions of the genome, Y-chromosome gene diversity in Taiwan mountain tribes significantly increases from North to South.ConclusionThe geographic distribution and the diversity accumulated in the O1a*-M119, O1a1*-P203, O1a2-M50 and O3a2-P201 haplogroups on one hand, and in the O2a1-M95/M88, O3a*-M324, O3a1c-IMS-JST002611 and O3a2c1a-M133 haplogroups on the other, support a pincer model of dispersals and gene flow from the mainland to the islands which likely started during the late upper Paleolithic, 18,000 to 15,000 years ago. The branches of the pincer contributed separately to the paternal gene pool of the Philippines and conjointly to the gene pools of Madagascar and the Solomon Islands. The North to South increase in diversity found for Taiwanese Austronesian speaking groups contrasts with observations based on mitochondrial DNA, thus hinting to a differentiated demographic history of men and women in these populations.

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Section: Resultsmentioning

confidence: 61%

“…Maps are based on data from Additional file 1: Tables S1 and S2 and from literature data [12,27,30,36,39,40,62]. Panels are labeled according to ISOGG2011 [8,42,43].…”

Section: Resultsmentioning

confidence: 99%

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Taiwan Y-chromosomal DNA variation and its relationship with Island Southeast Asia

et al. 2014

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“…Detailed explanations of the study were provided to each participant. Individual written informed consent was obtained, and a short standardized questionnaire was used to collect personal epidemiological data (age, sex, location, and ethnicity (20) who were living in the Saint-Laurent du Maroni area of French Guiana. All of the participants were considered healthy individuals except the 9 people from New Caledonia, who were outpatients seen in a hospital dermatology unit.…”

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confidence: 99%

Molecular Epidemiology of Merkel Cell Polyomavirus: Evidence for Geographically Related Variant Genotypes

et al. 2014

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“…The Hmong people originate from Southern China and have at several points in their history migrated through Southeast Asia to escape war and persecution. It was after the Vietnam war and conflicts in Laos that large groups emigrated to the Americas [Brucato et al, ]. In the United States, over 200,000 individuals of Hmong ancestry are located primarily in the central valley of California, as well as several midwest and northeast states.…”

Section: Introductionmentioning

confidence: 99%

A novel mutation in two Hmong families broadens the range of STRA6‐related malformations to include contractures and camptodactyly

Marcadier

Mears

Woods³

et al. 2015

American J of Med Genetics Pt A

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PDAC (also termed Matthew Wood) syndrome is a rare, autosomal recessive disorder characterized by pulmonary hypoplasia/aplasia, diaphragmatic defects, bilateral anophthalmia, and cardiac malformations. The disorder is caused by mutations in STRA6, an important regulator of vitamin A and retinoic acid metabolism. We describe six cases from four families of Hmong ancestry, seen over a 30 years period in California. These include: (i) consanguineous siblings with a combination of bilateral anophthalmia, diaphragmatic abnormalities, truncus arteriosus, and/or pulmonary agenesis/hypoplasia; (ii) a singleton fetus with bilateral anophthalmia, pulmonary agenesis, cardiac malformation, and renal hypoplasia; (iii) a sibling pair with a combination of antenatal contractures, camptodactyly, fused palpebral fissures, pulmonary agenesis, and/or truncus arteriosus; (iv) a fetus with bilateral anophthalmia, bushy eyebrows, pulmonary agenesis, heart malformation, and abnormal hand positioning. The phenotypic spectrum of PDAC syndrome has until now not included contractures or camptodactyly. Sequencing of STRA6 in unrelated members of families three and four identified a novel, shared homozygous splice site alteration (c.113 + 3_4delAA) that is predicted to be pathogenic. We hypothesize this may represent a unique disease allele in the Hmong. We also provide a focused review of all published PDAC syndrome cases with confirmed or inferred STRA6 mutations, illustrating the phenotypic and molecular variability that characterizes this disorder.

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The Hmong Diaspora: Preserved South-East Asian genetic ancestry in French Guianese Asians

Cited by 7 publications

References 51 publications

Taiwan Y-chromosomal DNA variation and its relationship with Island Southeast Asia

Taiwan Y-chromosomal DNA variation and its relationship with Island Southeast Asia

Molecular Epidemiology of Merkel Cell Polyomavirus: Evidence for Geographically Related Variant Genotypes

A novel mutation in two Hmong families broadens the range of STRA6‐related malformations to include contractures and camptodactyly

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