The HLA-DRB1 allele polymorphisms and nasopharyngeal carcinoma

Abstract

Human leukocyte antigen (HLA)-DRB1 has been reported to influence individual's susceptibility to nasopharyngeal carcinoma (NPC) by many studies in recent years; however, these studies provided controversial results. The meta-analysis was thus conducted here to estimate the relationship between HLA-DRB1 polymorphisms and NPC. After an extensive review of journals from various databases (PubMed, the Web of Science, Embase, China National Knowledge Internet (CNKI), and Wanfang Database), 8 out of 69 case-control studies, including 778 cases and 1148 controls, were extracted. The results showed that 4 of 13 polymorphisms allele are statistically significantly associated with NPC, among them, HLA-DRB1*3, HLA-DRB1*9, and HLA-DRB1*10 may increase the risk of NPC while HLA-DRB1*01 has the opposite effect. The pooled odds ratio and 95 % confidence interval (CI) were 1.702 [95 % CI (1.047, 2.765)], 1.363 [95 % CI (1.029, 1.806)], 1.989 [95 % CI (1.042, 3.799)], and 0.461 [95 % CI (0.315, 0.676)], respectively. In a further ethnicity-based subgroup analysis, HLA-DRB1*08, HLA-DRB1*11, and HLA-DRB1*16 were found to be linked with NPC in Asian, Tunisian, and Caucasian, respectively. In Asian, HLA-DRB1*03, 08, and 10 may elevate the risk whereas HLA-DRB1*09 could lower it. In Tunisian, HLA-DRB1*01 and 11 are the protective factors while HLA-DRB1*03 is the only risk factor. In Caucasian, HLA-DRB1*01 and 03 increase the risk and HLA-DRB1*16 lowers it. The most frequent statistically associated gene is found to be HLA-DRB1*03 which has protective influence on Asian and Tunisian. In conclusion, HLA-DRB1*01, DRB1*03, DRB1*09, and DRB1*10 are related with NPC susceptibility, and the association of HLA-DRB1*08, DRB1*11, and DRB1*16 with NPC risk are significantly different in different ethnicities.

HLA II genes distribution in Epstein–Barr virus-associated nasopharyngeal carcinoma and other tumors of the oral cavity patients in Russia

“…В нашем исследовании у пациентов с РНГ выявлена более низкая, чем в контрольной группе, частота HLA-DQB1*0301 (16,1 % против 25,3 %; р <0,05), а у пациентов с ДОПР она не отличалась от таковой [24]. В той же работе отмечено, что связь вариантов HLA-DRB1*08, *11 и *16 с риском развития РНГ значительно различается в зависимости от этнической принадлежности.…”

“…После стратификации результатов исследований с учетом популяционной принадлежности пациентов, по данным H. Yang и соавт. [24], для азиатских популяций чувствительность к РНГ связана с вариантами HLA-DRB1*03, *08 и *10, по данным K. Yao и соавт. [25] -с HLA-DRB1*03, *08, а также с вариантом HLA-DRB1*09, который в работе H. Yang и соавт.…”

“…[25] -с HLA-DRB1*03, *08, а также с вариантом HLA-DRB1*09, который в работе H. Yang и соавт. [24] был протективным. В исследовании K. Yao и соавт.…”

Histocompatibility locus antigens regions contribute to the ethnicity bias of Epstein‐Barr virus‐associated nasopharyngeal carcinoma in higher‐incidence populations

“…HLA genes express various proteins of the immune system and help it to process and present foreign antigens, thereby making those antigens vulnerable to immune lysis. Both susceptibility for NPC and survival after diagnosis are associated with such processing and presentations of the viral antigens and, thus, with the proper expression of HLA antigens . HLA antigen polymorphisms are well documented for their association with ethnic variations in human populations .…”

“…Both susceptibility for NPC and survival after diagnosis are associated with such processing and presentations of the viral antigens and, thus, with the proper expression of HLA antigens. [22][23][24] HLA antigen polymorphisms are well documented for their association with ethnic variations in human populations. [25][26][27][28] As the polymorphisms in the HLA regions might affect the presentations of EBV antigens to cytotoxic T lymphocytes, these polymorphisms may be expected to explain the ethnic variations in the incidence patterns of EBV-associated NPC.…”