The HLA-DQB alleles and amino acid variants of the vitamin D-binding protein in diabetic patients in Alsace

Ongagna, Jean-Claude; Kaltenbacher, M.C; Sapin, R; Pinget, M.; Belcourt, A.

doi:10.1016/s0009-9120(00)00197-1

Cited by 38 publications

(31 citation statements)

References 30 publications

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“…As previously demonstrated [17], the homozygous genotypes (Asp/Asp, Glu/Glu) and allele frequencies of DBP polymorphism of codon 416 in type 1 diabetes differed significantly ( P b 0.01) from those control subjects (Fig. 1).…”

Section: Dbp Polymorphism In Type 1 Diabetic Patientssupporting

confidence: 74%

“…The PCR products were digested with HaeIII and the genotypes determined by agarose gel electrophoresis [17].…”

Section: Dna Amplification and Restriction Fragment Length Polymorphimentioning

confidence: 99%

“…Having pointed out the correlation between vitamin Dbinding protein allele in codon 416 and type 1 diabetes in a previous study [17], we, therefore, investigated the polymorphism in codon 416 of the DBP gene for an association with autoimmune markers of type 1 diabetes.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D-binding protein gene polymorphism association with IA-2 autoantibodies in type 1 diabetes

Ongagna¹,

Pinget²,

Belcourt³

2005

Clinical Biochemistry

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Section: Dbp Polymorphism In Type 1 Diabetic Patientssupporting

confidence: 74%

“…The PCR products were digested with HaeIII and the genotypes determined by agarose gel electrophoresis [17].…”

Section: Dna Amplification and Restriction Fragment Length Polymorphimentioning

confidence: 99%

See 1 more Smart Citation

Vitamin D-binding protein gene polymorphism association with IA-2 autoantibodies in type 1 diabetes

Ongagna¹,

Pinget²,

Belcourt³

2005

Clinical Biochemistry

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“…VDBP also associates with membranebound immunoglobulin on the surface of B lymphocytes and with IgG Fc receptors on the membranes of T lymphocytes, suggesting its possible role in the immunopathogenesis and progression of the disease. Furthermore, an association of VDBP with type 1 and type 2 diabetes, glucose intolerance, hypoinsulinemia/ hyperinsulinemia, and/or insulin resistance and pregnancy associated-diabetes was reported in Dogrib Indians (14), American Anglos and Hispanics (15), Pima Indians (16), Japanese (17,18), Russians (19), Polynesian Island populations (20), Alsacian French (21,22), Bantu (23), and Finnish populations (24). VDBP was also found in the vitreous in diabetic macular edema, along with pigment epithelium-derived factor, apoA-4, apoA-1, trip-11, and plasma retinol-binding protein (RBP).…”

Section: Downregulated Urinary Proteins In Diabetic Nephropathymentioning

confidence: 99%

Proteomic Identification of Urinary Biomarkers of Diabetic Nephropathy

et al. 2007

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OBJECTIVE -Diabetic nephropathy is a serious complication of both type 1 and type 2 diabetes, and, unless arrested, leads to end-stage renal disease. Current diagnosis consists of urine assays of microalbuminuria, which have inadequate specificity and sensitivity.RESEARCH DESIGN AND METHODS -We used proteomic analyses to identify novel biomarkers of nephropathy in urine from type 2 diabetic patients with demonstrated normo-, micro-, or macroalbuminuria. Samples were analyzed by fluorescence two-dimensional (2-D) differential in-gel electrophoresis (DIGE), and protein identification was performed by liquid chromatography-tandem mass spectrometry.RESULTS -2-D DIGE analysis of the urinary proteome in diabetes with nephropathy identified 195 protein spots representing 62 unique proteins. These proteins belonged to several functional groups, i.e., cell development, cell organization, defense response, metabolism, and signal transduction. Comparisons between control and diabetic subjects with different stages of renal dysfunction revealed the differential expression of several proteins. Spot volume quantification identified 7 proteins that were progressively upregulated with increasing albuminuria and 4 proteins that exhibited progressive downregulation. The majority of these potential candidate biomarkers were glycoproteins.CONCLUSIONS -These data demonstrate the ability of proteomic analyses to reveal potential biomarkers for diabetic nephropathy in urine, an important step forward in advancing accurate diagnosis and our understanding of disease mechanisms. Diabetes Care 30:629 -637, 2007

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“…In humans, polymorphisms of the vitamin D binding protein (DBP) [4] and 25(OH)D 3 -1-alpha-hydroxylase (CYP27B1) [5] have been associated with type 1 diabetes.…”

Section: Introductionmentioning

confidence: 99%

CYP2R1 (vitamin D 25‐hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans

Ramos-Lopez

Bruck

Jansen

et al. 2007

Diabetes Metabolism Res

158

113

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The HLA-DQB alleles and amino acid variants of the vitamin D-binding protein in diabetic patients in Alsace

Cited by 38 publications

References 30 publications

Vitamin D-binding protein gene polymorphism association with IA-2 autoantibodies in type 1 diabetes

Vitamin D-binding protein gene polymorphism association with IA-2 autoantibodies in type 1 diabetes

Proteomic Identification of Urinary Biomarkers of Diabetic Nephropathy

CYP2R1 (vitamin D 25‐hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans

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