The HLA-B7 allele confers susceptibility to breast cancer in Spanish women

Association of MHC class-III gene polymorphisms with ER-positive breast cancer in Chinese Han population

“…Several studies have investigated the association of the HLA class I and class II regions in breast cancer in different ethnic groups and areas (Ghaderi et al, 2001;Lavado et al, 2005;Baccar et al, 2006;Cantú de León et al, 2009;Gun et al, 2012;Mahmoodi et al, 2012). Attempts have also been made to reveal the relationship between the genes in the MHC class III region and mammary cancer.…”

HLA-DRB1,-DQA1 and -DQB1 Allele and Haplotype Frequencies in Female Patients with Early Onset Breast Cancer

“…Certain factors can cause the appearance of the disease and also they often are able to help the tumor to continue its growth and would result in metastasis. By accepting the immunological surveillance as an important mechanism in tumor gene process, inheriting HLA class II alleles can make an individual resistant or susceptible to tumor presentation [15][16][17][18]. Beside that, the dominant pathogen of a geographical area, could affect the frequency of presentation of different HLA alleles [18].…”

“…In a more recent study, Cantú de León et al [17] used high-resolution HLA class I and class II allele typing in a group of 100 Mexican mestizo breast cancer patients and 99 matched healthy controls. They found that DRB1*1301 is presented in seven cases but in only one control, and also they report a negative association of DQB1*0301 allele with the disease (OR = 0.078, p = 0.00001).…”

“…HLA-class l molecules present peptide fragments (viral and self peptides) to the circulating cytotoxic CD8 + T cells and HLA-class ll molecules present exogenously derived peptides such as bacteria and chemical toxins to circulating CD4 + T cells. Previous studies have indicated that certain HLA-class ll alleles or haplotypes may be associated with the risk of certain cancers, such as cervical cancer [9,10], gastric cancer [11,12], ovarian cancer [13], malignant melanoma [14] and breast cancer [15][16][17][18]. The current study investigate positive or negative association of HLA-class II, HLA-DRB1,-DQA1,-DQB1, alleles and haplotype frequencies with breast cancer in two groups of female patients, including women with early-onset of the disease and patients diagnosed who are over 40 years old.…”

Negative Association of the HLA-DQB1*02 Allele with Breast Cancer Development among Jordanians

“…The inconsistency of these results could be explained by differences among different geographical zones. These variations are due the presentation of bacterial and viral antigens to T cells, which in turn triggers the necessary immune response to the pathogens (Lavado et al, 2005). Thus, the frequency of the HLA alleles is determined by the dominant pathogens in each particular region.…”