2019
DOI: 10.1101/19003590
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The HIV-Associated Neurocognitive Disorders in Zambia (HANDZ) Study: Protocol of a research program in pediatric HIV in sub-Saharan Africa

Abstract: Approximately 10% of youth in sub-Saharan Africa are infected with the Human Immunodeficiency Virus. In Zambia, it is estimated that over 72,000 children have HIV infection, and despite access to combination antiretroviral therapy, many will experience HIV-associated neurocognitive deficits (HAND) encompassing cognitive and psychiatric sequelae such as global intellectual delay, executive dysfunction, and depressed mood. However, little is known about the neurocognitive profile of such children, the long-term … Show more

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Cited by 11 publications
(19 citation statements)
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“…Detailed methods for the parent HANDZ study have previously been described. 18 HIV-infected subjects aged eight to 17 years were recruited from the Pediatric Center of Excellence in Lusaka, Zambia, from October 2017 to January 2019 from outpatient medication refill visits. For the imaging substudy of HANDZ, the first 34 eligible subjects with HIV from HANDZ had brain MRI performed.…”
Section: Overviewmentioning
confidence: 99%
See 4 more Smart Citations
“…Detailed methods for the parent HANDZ study have previously been described. 18 HIV-infected subjects aged eight to 17 years were recruited from the Pediatric Center of Excellence in Lusaka, Zambia, from October 2017 to January 2019 from outpatient medication refill visits. For the imaging substudy of HANDZ, the first 34 eligible subjects with HIV from HANDZ had brain MRI performed.…”
Section: Overviewmentioning
confidence: 99%
“…HIV-related clinical information and past medical history were determined through chart review, and through subject and parental interviews. 18…”
Section: Overviewmentioning
confidence: 99%
See 3 more Smart Citations