The history of the tetracyclines

Nelson, Mark L.; Levy, Stuart B.

doi:10.1111/j.1749-6632.2011.06354.x

Cited by 344 publications

(268 citation statements)

References 94 publications

(71 reference statements)

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“…The genus Streptomyces is a particularly abundant source of antibiotics (Barka et al, 2016). Almost all the actinobacteria that produce commercial antibiotics were isolated from soil (Nelson & Levy, 2011;Raja & Prabakarana, 2011). We isolated actinobacteria belonging to species that produce biologically active secondary metabolites.…”

Section: Discussionmentioning

confidence: 99%

Isolation and antimicrobial activities of actinobacteria closely associated with liquorice plants Glycyrrhiza glabra L. and Glycyrrhiza inflate BAT. in Xinjiang, China

Zhao

Liao

et al. 2016

Microbiology

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A total of 218 actinobacteria strains were isolated from wild perennial liquorice plants Glycyrrhiza glabra L. and Glycyrrhiza. inflate BAT. Based on morphological characteristics, 45 and 32 strains from G. inflate and G. glabra, respectively, were selected for further analyses. According to 16S rRNA sequence analysis, most of the strains belonged to genus Streptomyces and a few strains represented the rare actinobacteria Micromonospora, Rhodococcus and Tsukamurella. A total of 39 strains from G. inflate and 27 strains from G. glabra showed antimicrobial activity against at least one indicator organism. The range of the antimicrobial activity of the strains isolated from G. glabra and G. inflate was similar. A total of 34 strains from G. inflate and 29 strains from G. glabra carried at least one of the genes encoding polyketide synthases, non-ribosomal peptide synthetase and FADH 2 -dependent halogenase. In the type II polyketide synthase KSa gene phylogenetic analysis, the strains were divided into two major clades: one included known spore pigment production-linked KSa sequences and other sequences were linked to the production of different types of aromatic polyketide antibiotics. Based on the antimicrobial range, the isolates that carried different KSa types were not separated from each other or from the isolates that did not carry KSa. The incongruent phylogenies of 16S rRNA and KSa genes indicated that the KSa genes were possibly horizontally transferred. In all, the liquorice plants were a rich source of biocontrol agents that may produce novel bioactive compounds.

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Section: Discussionmentioning

confidence: 99%

Isolation and antimicrobial activities of actinobacteria closely associated with liquorice plants Glycyrrhiza glabra L. and Glycyrrhiza inflate BAT. in Xinjiang, China

Zhao

Liao

et al. 2016

Microbiology

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“…Moreover, the use of these drugs to treat inflammatory conditions is still not conclusive and, in some way, controversial as well as the abuse of some veterinary drugs, including tetracyclines, which have a global impact on the environment that could be of great relevance [44–50]. …”

Section: Introductionmentioning

confidence: 99%

Toxicological Implications and Inflammatory Response in Human Lymphocytes Challenged with Oxytetracycline

Cerbo

Palatucci

Rubino

et al. 2015

J Biochem & Molecular Tox

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Antibiotics are widely used in zoo technical and veterinary practices as feed supplementation to ensure wellness of farmed animals and livestock. Several evidences have been suggesting both the toxic role for tetracyclines, particularly for oxytetracycline (OTC). This potential toxicity appears of great relevance for human nutrition and for domestic animals. This study aimed to extend the evaluation of such toxicity. The biologic impact of the drug was assessed by evaluating the proinflammatory effect of OTC and their bone residues on cytokine secretion by in vitro human peripheral blood lymphocytes. Our results showed that both OTC and OTC‐bone residues significantly induced the T lymphocyte and non‐T cell secretion of interferon (IFN)‐γ, as cytokine involved in inflammatory responses in humans as well as in animals. These results may suggest a possible implication for new potential human and animal health risks depending on the entry of tetracyclines in the food‐processing chain.

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“…Tetracyclines have been used as both oral and systemic antibacterial agents for over 60 years following their discovery from soil samples in various locations in the midwestern United States (62). They act as protein synthesis inhibitors by binding to the 30S ribosomes of a wide range of both Gram-positive and Gram-negative bacteria.…”

Section: Tetracyclinesmentioning

confidence: 99%

Investigational Antimicrobial Agents of 2013

Pucci

Bush

2013

Clin Microbiol Rev

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SUMMARY New antimicrobial agents are always needed to counteract the resistant pathogens that continue to be selected by current therapeutic regimens. This review provides a survey of known antimicrobial agents that were currently in clinical development in the fall of 2012 and spring of 2013. Data were collected from published literature primarily from 2010 to 2012, meeting abstracts (2011 to 2012), government websites, and company websites when appropriate. Compared to what was reported in previous surveys, a surprising number of new agents are currently in company pipelines, particularly in phase 3 clinical development. Familiar antibacterial classes of the quinolones, tetracyclines, oxazolidinones, glycopeptides, and cephalosporins are represented by entities with enhanced antimicrobial or pharmacological properties. More importantly, compounds of novel chemical structures targeting bacterial pathways not previously exploited are under development. Some of the most promising compounds include novel β-lactamase inhibitor combinations that target many multidrug-resistant Gram-negative bacteria, a critical medical need. Although new antimicrobial agents will continue to be needed to address increasing antibiotic resistance, there are novel agents in development to tackle at least some of the more worrisome pathogens in the current nosocomial setting.

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The history of the tetracyclines

Cited by 344 publications

References 94 publications

Isolation and antimicrobial activities of actinobacteria closely associated with liquorice plants Glycyrrhiza glabra L. and Glycyrrhiza inflate BAT. in Xinjiang, China

Isolation and antimicrobial activities of actinobacteria closely associated with liquorice plants Glycyrrhiza glabra L. and Glycyrrhiza inflate BAT. in Xinjiang, China

Toxicological Implications and Inflammatory Response in Human Lymphocytes Challenged with Oxytetracycline

Investigational Antimicrobial Agents of 2013

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