The history of the pulmonary diffusing capacity for nitric oxide D L,NO

Borland, Colin; Guénard, H.

doi:10.1016/j.resp.2016.11.014

Cited by 6 publications

(1 citation statement)

References 44 publications

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“…While carbon monoxide (CO) has been the transfer gas of choice for the measurement of diffusing capacity, the use of nitric oxide (NO) as a potential alternative originated much later by separate and independent research teams [ 21 ]. The first two abstracts on DLNO originated from the United Kingdom in the 1980s [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

The need for race-specific reference equations for pulmonary diffusing capacity for nitric oxide

et al. 2021

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Background Few reference equations exist for healthy adults of various races for pulmonary diffusing capacity for nitric oxide (DLNO). The purpose of this study was to collect pilot data to demonstrate that race-specific reference equations are needed for DLNO. Methods African Americans (blacks) were chosen as the comparative racial group. In 2016, a total of 59 healthy black subjects (27 males and 32 females) were recruited to perform a full battery of pulmonary function tests. In the development of DLNO reference equations, a white reference sample (randomly drawn from a population) matched to the black sample for sex, age, and height was used. Multiple linear regression equations for DLNO, alveolar volume (VA), and pulmonary diffusing capacity for carbon monoxide (DLCO) using a 5–6 s breath-hold were developed. Results Our models demonstrated that sex, age2, race, and height explained 71% of the variance in DLNO and DLCO, with race accounting for approximately 5–10% of the total variance. After normalizing for sex, age2, and height, blacks had a 12.4 and 3.9 mL/min/mmHg lower DLNO and DLCO, respectively, compared to whites. The lower diffusing capacity values in blacks are due, in part, to their 0.6 L lower VA (controlling for sex and height). Conclusion The results of this pilot data reveal small but important and statistically significant racial differences in DLNO and DLCO in adults. Future reference equations should account for racial differences. If these differences are not accounted for, then the risk of falsely diagnosing lung disease increase in blacks when using reference equations for whites.

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Section: Introductionmentioning

confidence: 99%