The History of Psoriasis

Stokar, Evan; Goldenberg, Gary

doi:10.1177/247553031420a00407

Cited by 1 publication

(1 citation statement)

References 14 publications

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“…It can occur at any age, but the higher prevalence is around the age of 50 -69. The emotional and social impact of psoriasis on patients is very important, they face stigma, social isolation, anxiety, depression and even suicidal tendencies [1,2]. Depression, a real public health problem, has an increasing prevalence and a negative impact on the individual and society.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Psychiatric Comorbidities in Patients With Psoriasis and Their Evolution Under Treatment

MARCULESCU¹

2023

FARMACIA

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Psoriasis is a chronic, immune-mediated inflammatory dermatosis that associates a number of conditions such as cardiovascular disease, metabolic syndrome, inflammatory bowel disease, neoplasia or psychiatric disorders, amongst the most frequent being depression and anxiety. This article aims to highlight the common pathogenetic pathway between psoriasis and psychiatric comorbidities, depression and anxiety, their prevalence among psoriasis patients, as well as the evolution of these conditions under psoriasis-specific systemic therapy (biological therapy and conventional systemic therapy) using specific scales to quantify depression severity and anxiety (HAM-D, HAM-A), determined at a certain time interval after the initiation of therapies. We conducted an observational study in the Dermatology Department of the Slatina Emergency County Hospital on a group of 51 patients clinically diagnosed with psoriasis. Thus, we found that the degree of mental impairment in the studied group was significant, 49% of patients showed mild depression, 15.7% moderate depressive episodes and 5.9% severe depression. Only 29.4% were not affected by depression. In terms of anxiety, 21.6% had moderate anxiety. Psoriasis is a chronic condition associated with the secretion of numerous pro-inflammatory cytokines. Increased levels of pro-inflammatory cytokines are also found in major depressive disorders. Thus, the common pathogenic pathway between psoriasis and depression may be the overexpression of proinflammatory cytokines such as IL-6, IL-17 or TNF-α. In the last two decades, with the advent of biological therapies, the treatment of psoriasis has evolved dramatically, and they have also had a positive impact on comorbidities, particularly psychiatric ones. RezumatPsoriazisul este o dermatoză inflamatorie cronică, imun-mediată, care asociază o serie de afecțiuni precum cele cardiovasculare, sindrom metabolic, boli inflamatorii intestinale, neoplazii sau tulburări psihiatrice, mai frecvent întâlnite fiind depresia și anxietatea. În acest articol ne propunem să evidențiem calea patogenică comună între psoriazis și comorbiditățile psihiatrice, depresie și anxietate, prevalența acestora în rândul pacienților cu psoriazis, dar și evoluția acestor afecțiuni sub terapie sistemică specifică pentru psoriazis (terapie biologică și terapie sistemică convențională) prin utilizarea unor scale specifice pentru cuantificarea gradului de depresie și anxietate (HAM-D, HAM-A), determinate la un anumit interval de timp de la inițierea terapiilor. Am efectuat un studiu observațional în cadrul Secției de Dermatologie a Spitalului Județean de Urgență Slatina, pe un lot format din 51 de pacienți diagnosticați clinic cu psoriazis. Astfel, am descoperit faptul că gradul de afectare psihică la lotul studiat a fost unul semnificativ, 49% dintre pacienți au prezentat depresie ușoară, 15,7% episoade depresive moderate, iar 5,9% depresie severă. Doar un procent de 29,4% nu era afectat de depresie. În ceea ce privește anxietatea, 21,6% prezentau anxietate moderată....

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Section: Introductionmentioning

confidence: 99%

Prevalence of Psychiatric Comorbidities in Patients With Psoriasis and Their Evolution Under Treatment

MARCULESCU¹

2023

FARMACIA

View full text Add to dashboard Cite

show abstract

The History of Psoriasis

Cited by 1 publication

References 14 publications

Prevalence of Psychiatric Comorbidities in Patients With Psoriasis and Their Evolution Under Treatment

Prevalence of Psychiatric Comorbidities in Patients With Psoriasis and Their Evolution Under Treatment

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