The history-dependent features of muscle force production: A challenge to the cross-bridge theory and their functional implications

Hahn, Daniel; Han, Seong-won; Joumaa, Venus

doi:10.1016/j.jbiomech.2023.111579

Cited by 7 publications

(2 citation statements)

References 159 publications

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“…The most accepted mechanism for rFE exists at the sub-cellular level. Upon activation, titin becomes stiffer and shorter 39 , thereby contributing more 'passive force' to total force production following stretch as compared with a 'purely isometric' contraction 11 . The magnitude of rFE we observed in single fibres was 3 to 5-fold greater than in in-vivo voluntary contractions from the same participants even when matching experimental stretch-hold parameters across muscle scales (Figure 3).…”

Section: Tempering Of Rfe's Cellular Mechanisms When Scaling From The...mentioning

confidence: 99%

“…This increase in isometric force following a 'stretch-hold' contraction is called residual force enhancement (rFE), and is an intrinsic property of muscle unexplained by the cross-bridge theory 2 . The mechanisms contributing to rFE originate at the sub-cellular level 3,4 , and correspondingly, rFE has been observed in the half sarcomere 5 , sarcomere 6,7 , myofibril 6 , and the single muscle fibre 8 and joint level in humans [9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

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Residual force enhancement decreases when scaling from the single muscle fibre to joint level in humans

Hinks,

Jacob,

Patterson

et al. 2024

Preprint

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Residual force enhancement (rFE), defined as increased isometric force following active lengthening compared to a fixed-end isometric contraction at the same muscle length and level of activation, is present across all scales of muscle. While rFE is always present at the cellular level, often rFE ‘non-responders’ are observed during joint-level voluntary contractions. We compared rFE between the joint level and single fibre level (vastus lateralis biopsies) in 16 young males.In-vivovoluntary knee-extensor rFE was measured by comparing steady-state isometric torque between a stretch-hold (maximal activation at 150°, stretch to 70°, hold) and a fixed-end isometric contraction, with ultrasonographic recording of vastus lateralis fascicle length (FL). Fixed-end contractions were performed at 67.5°, 70°, 72.5°, and 75°; the joint angle that most closely matched FL of the stretch-hold contraction’s isometric steady-state was used to calculate rFE. The starting and ending FLs of the stretch-hold contraction were expressed as % optimal FL, determined via torque-angle relationship. In single fibre experiments, the starting and ending fibre lengths were matched relative to optimal length determined fromin-vivotesting, yielding an average sarcomere excursion of ∼2.2-3.4µm. There was a greater magnitude of rFE at the single fibre (∼20%) than joint level (∼5%) (P=0.004), with ‘non-responders’ only observed at the joint level. By comparing rFE across scales within the same participants, we show the development of the rFE non-responder phenomenon is upstream of rFE’s cellular mechanisms, with rFE only lost rather than gained when scaling from single fibres to the joint level.

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Section: Tempering Of Rfe's Cellular Mechanisms When Scaling From The...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Residual force enhancement decreases when scaling from the single muscle fibre to joint level in humans

Hinks,

Jacob,

Patterson

et al. 2024

Preprint

View full text Add to dashboard Cite

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Stretch-shortening cycles protect against the age-related loss of power generation in rat single muscle fibres

Patterson,

Hinks,

Njai

et al. 2024

Experimental Gerontology

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Muscle research in biomechanics – In celebration of the 50th Anniversary of the International Society of Biomechanics

Fontana

Dick

Han

2023

Journal of Biomechanics

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The history-dependent features of muscle force production: A challenge to the cross-bridge theory and their functional implications

Cited by 7 publications

References 159 publications

Residual force enhancement decreases when scaling from the single muscle fibre to joint level in humans

Residual force enhancement decreases when scaling from the single muscle fibre to joint level in humans

Stretch-shortening cycles protect against the age-related loss of power generation in rat single muscle fibres

Muscle research in biomechanics – In celebration of the 50th Anniversary of the International Society of Biomechanics

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