The Histopathology of the Endometrium

Dallenbach-Hellweg, Gisela

doi:10.1007/978-3-662-07788-7_3

Cited by 30 publications

(40 citation statements)

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“…A number of enzymatic activities have been found to change during the menstrual cycle (9,10). Variations of the levels of E 2 -DH during the cycle are, however, of particular interest since this enzyme has a direct effect on the concentrations of E 2 in the tissue.…”

Section: Discussionmentioning

confidence: 99%

Estradiol and 20α-Dihydroprogesterone Dehydrogenase Activities in Human Endometrium During the Menstrual Cycle

Tseng¹,

Gurpide²

1974

Endocrinology

185

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Section: Discussionmentioning

confidence: 99%

Estradiol and 20α-Dihydroprogesterone Dehydrogenase Activities in Human Endometrium During the Menstrual Cycle

Tseng¹,

Gurpide²

1974

Endocrinology

185

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“…These cells appeared often as 'clear' cells or ciliated cells. It has been claimed that the occurrence o f clear or ciliated cells in the endometrial glands were under estrogenic dependency, and that they were particularly abundant in estrogen-primed endometria (2). In 1 case o f hyperplasia, obviously progestogen-treated, no k-casein cells were to be found.…”

Section: Discussionmentioning

confidence: 96%

Immunohistochemical Demonstration of Several Tumour Markers in Neoplastic and Preneoplastic States of the Uterine Mucosa

Hustin¹

1978

Gynecol Obstet Invest

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Enzymic immunocy to chemical demonstration of five tumour markers (CEA, AFP, k-casein, total HCG and its Β-subunit) was performed on various pathological states of the uterine mucosa. CEA was constantly found in areas of atypical hyperplasia and in more than 60% of cancers. ĸ-Casein on the contrary was an unexpected but frequent finding in cystic hyperplasia. The other antigens were not, or exceptionally, detected in the tissues. We believe that CEA detection may be a very useful tool in delineating preneoplastic changes of the endometrium while the presence of k-casein ‘storing cells’ might point to an unopposed estrogen action.

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“…These cells are equivalent to the metrial gland cells of rodents for which an abundant literature exists [18]. There is now general agreement that these cells are derived from the bone marrow, rather than from stromal stem cells, as had been assumed by Dallenbach-Hellweg [17]. The cells have been well characterised immunohistochemically [19,20].…”

Section: Discussionmentioning

confidence: 98%

“…The classical name is granular cell (Kornchenzelle, K cell) [17]. Pijnenborg et al [16] used the term endometrial granulocyte for this cell type, which appeared to be confined to the endometrium.…”

Section: Discussionmentioning

confidence: 99%

Imbalance of mononuclear cell infiltrates in the placental tissue from foetuses after spontaneous abortion versus therapeutic termination from 8th to 12th weeks of gestational age

Lambropoulou

Tamiolakis²,

Venizelos

et al. 2006

Clin. Exper.Med.

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Placental macrophages (Hofbauer cells) are located close to trophoblastic cells and foetal capillaries, which make them perfect candidates for involvement in regulatory processes within the villous core. Their capacity of producing several cytokines and prostaglandin-synthesising enzymes, and expressing vascular endothelial growth factor, indicate a possible role in placental development and angiogenesis in order to support pregnancy. Common cells to Hofbauer macrophages sharing similar cell surface markers (HLA-A, -B, -C and leukocyte common antigen) have been reported in the stroma, decidua and amnion, indicating additional foetal protection. Yet this is not always the case. Most spontaneous abortions occur before 12 weeks' gestation, and most are due to chromosomal errors in the conceptus. Relatively few truly spontaneous abortions take place between 12 and 20 weeks' gestation. Thereafter, between 20 and 30 weeks, another type of premature spontaneous termination becomes prevalent, which is due to ascending infection. The numbers of cells expressing the various markers of the monocytemacrophage lineage change throughout pregnancy. In the present study, we investigated the immunohistochemical expression of mononuclear infiltrations in paraffin-embedded placentas, from foetuses after spontaneous abortion (8th, 10th and 12th weeks of gestational age), and those after therapeutic abortion at the same time, using a panel of monoclonal antibodies for the identification of leukocytes (CD45/LCA), B-lymphocytes (CD20/L-26), T lymphocytes (CD45RO/UCHL1), CD68 and CD14 cells. Immunologic factors in human reproductive failure are plausible mechanisms of infertility and spontaneous abortion. Approximately 25% of cases of premature ovarian failure appear to result from an autoimmune aetiology. Unfortunately, current therapeutic options for these women are limited to exogenous hormone or gamete substitution. Local inflammations at the sites of endometriosis implants are postulated to mediate the pain and reduced fecundability associated with this clinical syndrome. The recruitment of immune cells, particularly monocytes and T-cells, neovascularisation around foci of invading peritoneal lesions, and the possible development of antiendometrial autoantibodies support an immunologic basis of this disorder. To date, treatment of pain and infertility associated with endometriosis is primarily surgical, although immune-based adjuvants are theoretical possibilities for the future. Finally, although hypotheses supporting immunologic mechanisms of recurrent pregnancy loss have been popular over the past decade, most clinical investigations in this area do not provide compelling evidence for this position. Reputable specialists in reproductive medicine use experimental immunotherapies judiciously in selected cases of repetitive abortion. For example, the use of anticoagulation therapy can be beneficial in cases with documented antiphospholipid antibodies. At present, however, efficacious immunotherapy protocols for general application ...

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The Histopathology of the Endometrium

Cited by 30 publications

References 0 publications

Estradiol and 20α-Dihydroprogesterone Dehydrogenase Activities in Human Endometrium During the Menstrual Cycle

Estradiol and 20α-Dihydroprogesterone Dehydrogenase Activities in Human Endometrium During the Menstrual Cycle

Immunohistochemical Demonstration of Several Tumour Markers in Neoplastic and Preneoplastic States of the Uterine Mucosa

Imbalance of mononuclear cell infiltrates in the placental tissue from foetuses after spontaneous abortion versus therapeutic termination from 8th to 12th weeks of gestational age

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