The Histopathology of Nonsteroidal Anti-inflammatory Drug-Associated Colitis

Reactive gastropathy is associated with inflammatory conditions throughout the gastrointestinal tract

“…[24][25][26] A significant association was also present with focal active colitis, which has also been linked to NSAID use. 29,30 Our data also support an indirect association between NSAID consumption and collagenous colitis, a relationship that has been previously described. [31][32][33] In contrast, neither lymphocytic nor ischaemic colitis was significantly associated with reactive gastropathy.…”

Pathological effects of drugs on the gastrointestinal tract: a review

“…Driman and Preiksaitis demonstrated that oral sodium phosphate solutions can produce a variety of mild pathological findings in the colon, including aphthoid lesions/erosions, focal active colitis, and mildly increased crypt epithelial apoptosis [57]. When Goldstein and Cinenza described NSAID-related colitis, they described similar changes, including patchy, mild inflammation, often with neutrophils, and increased intraepithelial lymphocytes; eosinophils and crypt epithelial apoptosis were also prominent [58]. Importantly, the diffuse crypt architectural distortion of ulcerative colitis (UC) and granulomas of Crohn disease are lacking.…”

Morphological Classification of Corrupted Colonic Crypts in Ulcerative Colitis

“…Architectural crypt irregularities in UC have received various descriptive terms such as ramification of the crypts (5) considerable branching at the base of the crypts (6), crypt bifurcations (7), architectural aberrations (8), architectural crypt distortion (9) and crypt architectural disarray (10), to name some. In this work, crypts with architectural distortions will be referred to as corrupted colonic crypts (11,12).…”