The histopathology of lupus erythematosus panniculitis

Sánchez, Néstor P.; Peters, Margot S.; Winkelmann, R. K.

doi:10.1016/s0190-9622(81)70129-4

Cited by 138 publications

(73 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…DLE and SLE had been known to develop in approximately 70% and 50% of patients with LEP. 4,17 Interestingly, our series showed lower frequency of both DLE and SLE (about 30% and 10%), and this observation was also seen in more recent studies from other authors. 6,[9][10][11] Antinuclear antibody was positive in almost half of the patients, but the titer was low even in the ones with SLE.…”

Section: Discussionsupporting

confidence: 90%

“…Fountain 19 asserted that the histopathologic features of this entity are not specific for LE, whereas Winkelmann 16 1 1 1 0 0 1 0 0 1 1 1 1 1 1 2 2 1 1 0 1 0 0 1 1 1 0 1 1 3 3 1 1 1 1 1 1 1 0 1 0 1 0 4 4 1 the histopathologic pattern may be characteristic even in the absence of epidermal changes typical of DLE. According to these and other authors, 9,10,16,17,20,21 the presence of lymphocytic nuclear dust within a patchy lymphoplasmacytic infiltrate in the fat lobules and hyaline fat necrosis is a clue for histopathologic diagnosis of LEP. Although these histopathologic changes may not be specific, it seems to be at least characteristic and constant.…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Lupus Erythematosus Panniculitis: Clinicopathological, Immunophenotypic, and Molecular Studies

Park

Choi²,

Kim³

et al. 2010

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Lupus erythematosus panniculitis (LEP) is an inflammatory disorder of the subcutaneous fat in patients with lupus erythematosus (LE). It is a rare variant of the disease, which occurs approximately in 1%-3% of patients with cutaneous LE. The purpose of this study was to investigate the clinical, histopathologic, immunophenotypical, and molecular profiles of LEP. We performed a retrospective study of 19 biopsy specimens from 17 patients with LEP. We reviewed their clinical data and reexamined the histopathology. Immunophenotyping and molecular studies were done using sections from paraffin-embedded formalin-fixed tissue. The most common clinical manifestation was a depressed patch on upper arm. Patients showed good response to variable treatment modalities, but, generally, relapse of panniculitis was noted when treatment was discontinued. Histopathologically, most specimens revealed lymphoplasmacytic lobular panniculitis with epidermal and dermal changes of LE, hyaline fat necrosis, and lymphoid follicles. Immunohistochemistry showed a mixture of T and B cells in dermis and subcutis with a slight preponderance of T cell. Although the polymerase chain reaction analysis of the T-cell receptor-gamma gene rearrangement showed a polyclonal smear in 89.5% of cases, a small portion of specimens demonstrated monoclonality. LEP is a chronic recurrent disease with characteristic features. Its diagnosis is often challenging, and a precise diagnosis is achievable only upon elaborate clinicopathologic correlation and integrated interpretation of all diagnostic criteria.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 94%

Lupus Erythematosus Panniculitis: Clinicopathological, Immunophenotypic, and Molecular Studies

Park

Choi²,

Kim³

et al. 2010

The American Journal of Dermatopathology

View full text Add to dashboard Cite

show abstract

“…The lesions may be pruritic, leave no scar when they involute, and if they recur, do so at the sites originally affected. 22 Histopathologically they show perivascular and periadnexal lymphohistiocytic infiltrate in the papillary and reticular dermis and intersti- tial mucin deposition. 21,23 Epidermal atrophy and changes in the dermal-epidermal junction are absent.…”

Section: Sontheimermentioning

confidence: 98%

“…Focal epidermal atrophy, dilation of the follicular ostium, hyperkeratosis, vacuolar degeneration of the dermal-epidermal junction, in addition to trabecular and lobular lymphocytic panniculitis accompanied by inflammatory infiltrate of the deep dermis and the subcutaneous cellular tissue are found histologically. 3,25 Yell et al, 26 in a study of 73 patients with systemic lupus erythematosus, found chronic discoid lesions in 17 (23%), in nine of whom (12%) the discoid lesions preceded the systemic symptoms. Tuffanelli, Dubois 27 reported discoid lesions in the course of SLE in 149 (28.6%) of the patients they studied; in 56 patients (10.8%) it was the initial manifestation of the disease, and in 79 patients (15.2%) the lesions were generalized.…”

Section: Sontheimermentioning

confidence: 99%

Lúpus eritematoso cutâneo: aspectos clínicos e laboratoriais

Berbert

Mantese

2005

An. Bras. Dermatol.

View full text Add to dashboard Cite

Lupus erythematosus is a connective tissue autoimmune disorder that demonstrates systemic, cutaneous, or both systemic and cutaneous manifestations. Cutaneous lesions are classified as specific and nonspecific. The variety of clinical manifestations of the disease is reflected in the broad spectrum of laboratory patterns. In this article we describe the distinct subsets of cutaneous lupus erythematosus, correlating them with histopathological, direct immunofluorescence and serological findings. Keywords: Skin diseases; Autoimmune diseases; Collagen diseases; Connective tissue diseases; Lupus erythematosus, Cutaneous/classification; Lupus erythematosus, Cutaneous/diagnosis. Resumo: O lúpus eritematoso é doença auto-imune do tecido conjuntivo que reúne manifestações exclusivamente cutâneas ou multissistêmicas, podendo apresentar exuberância de auto-anticorpos. As lesões cutâneas do lúpus eritematoso são polimorfas e podem ser específicas ou inespecíficas. A diversidade de manifestações clínicas da doença reflete-se no amplo espectro de achados laboratoriais. Este artigo descreve as variadas formas clínicas do lúpus eritematoso cutâneo correlacionan

show abstract

“…Direct immunofluorescence studies frequently reveal a positive lupus band test in overlying skin of the LEP [35].…”

Section: Diagnosismentioning

confidence: 99%

Intravenous Immunoglobulin in Lupus Panniculitis

Santo

Gomes

et al. 2009

Clinic Rev Allerg Immunol

View full text Add to dashboard Cite

Systemic lupus erythematosus (SLE) is a disease of unknown cause that may involve one or many organ or systems. Skin involvement is a major feature in this disease, and a wide variety of skin conditions may be present. Lupus erythematosus panniculitis (LEP) constitutes a rare form of cutaneous lupus characterized by recurrent nodular or plaque lesions that can vary from a benign and mild course to a more disfiguring disease. Initial therapy includes corticosteroids, antimalarials, and azathioprine and, in refractory cases, two antimalarials in association, mycophenolate mofetil, or other immunomodulators. Intravenous immuglobulin (IVIG) is used in many autoimmune disorders, like in SLE, although clinical trials have not yet taken place. In this report, we review skin manifestations of SLE and their treatment, IVIG, and finally a case of LEP successfully treated with IVIG when other therapy modalities failed.

show abstract

The histopathology of lupus erythematosus panniculitis

Cited by 138 publications

References 7 publications

Lupus Erythematosus Panniculitis: Clinicopathological, Immunophenotypic, and Molecular Studies

Lupus Erythematosus Panniculitis: Clinicopathological, Immunophenotypic, and Molecular Studies

Lúpus eritematoso cutâneo: aspectos clínicos e laboratoriais

Intravenous Immunoglobulin in Lupus Panniculitis

Contact Info

Product

Resources

About