The Histopathological Investigation of Pulpal Tissue following Heavy Orthopaedic Forces Produced by Rapid Maxillary Expansion

Taşpinar, F; Akgül, Nilgün; Şimşek, G; Ozdabak, Nur; Gündoğdu, Cemal

doi:10.1177/147323000303100305

Cited by 18 publications

(31 citation statements)

References 14 publications

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“…Kayhan et al 25 and Taspinar et al 26 suggested that repeated measurements of PBF at different stages of force application for evaluation of pulp hemodynamics were better than a single observation during force application. LDF can repeatedly measure PBF of the same tooth without causing damage to the pulp.…”

Section: Discussionmentioning

confidence: 99%

“…These histologic studies show inflammatory changes in the pulp tissue after orthopedic force application. 25,26 Both described areas of the vessels that were increased because of the inflammatory process.…”

Section: Discussionmentioning

confidence: 99%

“…[25][26][27] Kayhan et al 25 evaluated the histologic and histomorphometric changes in pulpal tissue of anchor premolar teeth after the RME procedure. Although they noticed more pronounced fibrotic elements in the pulpal tissue, investigators observed no differences in pre-dentin width, no change in the number of vessels, and no calcification deposits or vacuoles after 3 months of retention.…”

Section: Discussionmentioning

confidence: 99%

“…They concluded these results to be an adaptive vascular tissue response. Taspinar et al 26 investigated the effects of the heavy orthopedic forces produced by RME appliances on the pulpal tissue of upper premolar teeth using histopathologic techniques. They reported similar reversible vascular changes as Kayhan et al 25 in the pulpal tissue of upper premolar teeth.…”

Section: Discussionmentioning

confidence: 99%

“…Taspinar et al 26 observed histologic changes after RME on extracted first premolar tooth pulp. They concluded that the orthopedic forces applied by RME appliances caused reversible vascular changes in pulpal tissue of anchor upper premolar teeth.…”

Section: Introductionmentioning

confidence: 99%

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Pulpal blood flow changes due to rapid maxillary expansion

Babacan

Doruk

Bıçakçı

2010

The Angle Orthodontist

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Objective: To determine the pulpal blood flow (PBF) changes in anchorage teeth associated with the high forces of a rapid maxillary expansion (RME) appliance. Materials and Methods: The study was performed with 14 girls and 7 boys for a total of 21 patients between 10 and 15 years of age (mean, 13.1 6 1.39 years). A modified acrylic bonded RME appliance was used as an expansion appliance. Laser Doppler flowmetry was used for the pulpal perfusion measurements. Records were taken from 42 upper central incisors, 28 canines, and 42 first molars at the following time intervals: just before expansion (T1); at the first week of expansion (T2); at the end of the expansion process (T3); and at the third (T4), seventh (T5), and 12th weeks of retention (T6). The data gained were statistically evaluated by parametric tests. Results: PBF values of the anchorage teeth were doubled at the first week of expansion; however, these values began to decrease because of separation of the median palatal suture. PBF values tended to reach their initial values during the retention period. Pulpal perfusion changes of all examined anchorage teeth were similar to each other from the beginning to the end of the evaluation. Conclusion: PBF changes that occur with RME are reversible. (Angle Orthod. 2010;80:1136-1140

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Pulpal blood flow changes due to rapid maxillary expansion

Babacan

Doruk

Bıçakçı

2010

The Angle Orthodontist

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Orthodontic force application upregulated pain-associated prostaglandin-I2/PGI2-receptor/TRPV1 pathway-related gene expression in rat molars

Ohkura

Yoshiba

et al. 2017

Odontology

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This study aimed to analyze the mRNA expression and protein localization of prostaglandin I (PGI) synthase (PGIS), the PGI receptor (IP receptor) and transient receptor potential cation channel, subfamily V, member 1 (TRPV1) in force-stimulated rat molars, toward the elucidation of the PGI-IP receptor-TRPV1 pathway that is in operation in the pulp and possibly associated with orthodontic pain and inflammation. Experimental force was applied to the maxillary first and second molars by inserting an elastic band between them for 6-72 h. PGIS, PTGIR (the IP receptor gene), and TRPV1 mRNA levels in the coronal pulp were analyzed with real-time PCR. PGIS, IP receptor, and TRPV1 proteins were immunostained. The force stimulation induced significant upregulation of PGIS at 6-24 h, and PTGIR and TRPV1 at 6 and 12 h in the pulp. PGIS was immunolocalized in odontoblasts and some fibroblasts in the force-stimulated pulp. The IP receptor and TRPV1 immunoreactivities were detected on odontoblasts and some nerve fibers. It was concluded that PGIS, PTGIR, and TRPV1 in rat molar pulp were significantly upregulated shortly after the force application, and that the IP receptor was co-expressed on TRPV1-expressing nerves and odontoblasts. These findings suggest that the PGI-IP receptor-TRPV1 pathway is associated with the acute phase of force-induced pulp changes involving odontoblasts and nerves.

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Expression of HMGB1 in the periodontal tissue subjected to orthodontic force application by Waldo’s method in mice

Feng

et al. 2014

J Mol Hist

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Recent studies indicate that high mobility group box protein 1 (HMGB1) originating from periodontal ligament (PDL) cells can be a potential regulator in the process of orthodontic tooth movement and periodontal tissue remodeling. The aim of this study is to investigate HMGB1 expression in periodontal tissue during orthodontic tooth movement in mice according to Waldo's method. Six 7-week-old C57BL6 mice were used in these experiments. The elastic band was inserted into the teeth space between the right first and second maxillary molars. After 3 days of mechanical loading, mice were fixed with transcardial perfusion of 4 % paraformaldehyde in 0.1 M phosphate buffer (pH 7.4), and the maxillary was extracted for histochemical analyses. The histological examination revealed local PDL tear at the tension side and the formation of extensive cell-free hyaline zones at the compression side. The immunolocalization of HMGB1 was significantly presented at tension side of PDL, apical area and dental pulp, whereas at the compression side of PDL, the labeling of HMGB1 was almost undetectable as the presence of hyaline zone. Taken together, we concluded that the orthodontic tooth movement by Waldo's method leads to histological changes and HMGB1 expression pattern that differ from those of coil spring method, including PDL tear and extensive hyaline zone which may severely destroy periodontal tissue and in turn impede tooth movement.

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The Histopathological Investigation of Pulpal Tissue following Heavy Orthopaedic Forces Produced by Rapid Maxillary Expansion

Cited by 18 publications

References 14 publications

Pulpal blood flow changes due to rapid maxillary expansion

Pulpal blood flow changes due to rapid maxillary expansion

Orthodontic force application upregulated pain-associated prostaglandin-I2/PGI2-receptor/TRPV1 pathway-related gene expression in rat molars

Expression of HMGB1 in the periodontal tissue subjected to orthodontic force application by Waldo’s method in mice

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