The Histone Methyltransferase SDG724 Mediates H3K36me2/3 Deposition at <i>MADS50</i> and <i>RFT1</i> and Promotes Flowering in Rice

Sun, Changhui; Fang, Jun; Zhao, Taolan; Xu, Bo; Zhang, Fantao; Liu, Linchuan; Tang, Jiuyou; Zhang, Genfa; Deng, Xiping; Chen, Fan; Qian, Qian; Cao, Xiaofeng; Chu, Chengcai

doi:10.1105/tpc.112.101436

Cited by 107 publications

(120 citation statements)

References 67 publications

(120 reference statements)

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“…Members of this subgroup contain three conserved domains: an Associated with SET (AWS) domain, an SET domain, and a post-SET domain (26,27). A recent study proposed that rice SDG724 is a histone methyltransferase, because loss of SDG724 resulted in a decrease of global H3K36 methylation, and an in vitro assay revealed histone methyltransferase activity (28).…”

Section: Significancementioning

confidence: 99%

A methyltransferase required for proper timing of the vernalization response in Arabidopsis

Lee

Yun

Zhao

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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Prolonged exposure to winter cold enables flowering in many plant species through a process called vernalization. In Arabidopsis, vernalization results from the epigenetic silencing of the floral repressor FLOWERING LOCUS C (FLC) via a Polycomb Repressive Complex 2 (PRC2)-mediated increase in the density of the epigenetic silencing mark H3K27me3 at FLC chromatin. During cold exposure, a gene encoding a unique, cold-specific PRC2 component, VERNALIZATION INSENSITIVE 3 (VIN3), which is necessary for PRC2-mediated silencing of FLC, is induced. Here we show that SET DOMAIN GROUP 7 (SDG7) is required for proper timing of VIN3 induction and of the vernalization process. Loss of SDG7 results in a vernalization-hypersensitive phenotype, as well as more rapid cold-mediated up-regulation of VIN3. In the absence of cold, loss of SDG7 results in elevated levels of long noncoding RNAs, which are thought to participate in epigenetic repression of FLC. Furthermore, loss of SDG7 results in increased H3K27me3 deposition on FLC chromatin in the absence of cold exposure and enhanced H3K27me3 spreading during cold treatment. Thus, SDG7 is a negative regulator of vernalization, and loss of SDG7 creates a partially vernalized state without cold exposure.vernalization | flowering time | SET DOMAIN GROUP 7 S easonal timing of flowering is critical for reproductive success in many plant species. The timing of flowering is often strongly influenced by seasonal variables, such as day length and temperature. Vernalization, the process by which exposure to the prolonged cold of winter enables flowering in the spring, is an example of a temperature effect on flowering (1).Arabidopsis thaliana contains both vernalization-requiring accessions (winter annual) and accessions that do not require vernalization (summer annual). The vernalization requirement is conferred by FRIGIDA (FRI)-mediated up-regulation of the potent flowering repressor FLOWERING LOCUS C (FLC) (2, 3). The presence of active alleles of FRI and FLC ensures that flowering is repressed in the fall season. Summer annual accessions do not require vernalization to flower, because these accessions typically contain a mutant allele of FRI that is not able to up-regulate FLC (4).On perception of a sufficiently long period of cold, vernalization results in the chromatin-level suppression of FLC, which in turn provides competence to flower (3, 5). Thus, in Arabidopsis, vernalization is an environmentally induced epigenetic switch (6).Vernalization-mediated FLC silencing is associated with an increase of two chromatin modifications involving trimethylation of histone 3 at lysine 9 (H3K9me3) and at lysine 27 (H3K27me3) (7,8). The increase in H3K27me3 results from the action of the Polycomb Repressive Complex 2 (PRC2) on FLC chromatin (9). Many of the PRC2 components are conserved among plants, animals, and fungi (10, 11); however, a plant-specific PRC2-associated protein, VERNALIZATION INSENSITIVE 3 (VIN3), is required for vernalization and is uniquely expressed during cold (6). Thus, the...

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Section: Significancementioning

confidence: 99%

A methyltransferase required for proper timing of the vernalization response in Arabidopsis

Lee

Yun

Zhao

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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“…SDG701, related to Arabidopsis SDG2/ATRX3, regulates the tri‐methylation of H3K4 at Hd3a and RFT1 (Liu et al ., 2017). SDG724 , SDG725 and SDG708 encode proteins belong to SET domain family II; members of this family function in H3K36me2/3 modifications (Sun et al ., 2012; Sui et al ., 2013; Choi et al ., 2014; Liu et al ., 2016). Loss of function of any of these proteins results in late flowering in both LD and SD conditions.…”

Section: Introductionmentioning

confidence: 99%

SIP1 participates in regulation of flowering time in rice by recruiting OsTrx1 to Ehd1

et al. 2018

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Summary Flowering time (heading date) in rice (Oryza sativa) is an important agronomic trait that determines yield. The levels of histone H3 lysine 4 trimethylation (H3K4me3) modulated by TRITHORAX‐like proteins regulate gene transcription, flowering time and environmental stress responses. However, plant TRITHORAX‐like proteins have no known DNA‐binding domain, and therefore the mechanism that gives sequence specificity to these proteins remains unclear.Here, we show that the rice TRITHORAX‐like protein OsTrx1 is recruited to its target, Early heading date 1 (Ehd1), by the C2H2 zinc finger protein SDG723/OsTrx1/OsSET33 Interaction Protein 1 (SIP1). SIP1 binds to the promoter of Ehd1 and interacts with OsTrx1. Mutations in SIP1 led to a late heading date under long‐day and short‐day conditions. Defects in OsTrx1 or SIP1 led to reduced H3K4me3 levels at Ehd1, thus reducing Ehd1 expression.Together, our results show that the transcription factor SIP1 interacts with OxTrx1, allowing OsTrx1 to specifically target Ehd1, altering H3K4me3 levels, increasing Ehd1 expression and thereby promoting flowering.

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“…S6). We selected histone marks that are usually located within genes and that were previously analyzed for florigen genes of other plant species (Jiang et al, 2008;Adrian et al, 2010;He, 2012;Sun et al, 2012;Gu et al, 2013;Mascheretti et al, 2013;López-González et al, 2014). Four histone marks usually associated with active transcription were selected for chromatin analysis.…”

Section: Variation Of Zcn7 and Zcn8 Transcript Isoform Levels Under Fmentioning

confidence: 99%

Florigen-Encoding Genes of Day-Neutral and Photoperiod-Sensitive Maize Are Regulated by Different Chromatin Modifications at the Floral Transition

Mascheretti

Turner²,

Brivio³

et al. 2015

Plant Physiol.

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ORCID IDs: 0000-0002-3136-9594 (J.C.); 0000-0001-9746-2583 (V.R.).The activity of the maize (Zea mays) florigen gene ZEA CENTRORADIALIS8 (ZCN8) is associated with the floral transition in both day-neutral temperate maize and short-day (SD)-requiring tropical maize. We analyzed transcription and chromatin modifications at the ZCN8 locus and its nearly identical paralog ZCN7 during the floral transition. This analysis was performed with day-neutral maize (Zea mays ssp. mays), where flowering is promoted almost exclusively via the autonomous pathway through the activity of the regulatory gene indeterminate1 (id1), and tropical teosinte (Zea mays ssp. parviglumis) under floral inductive and noninductive photoperiods. Comparison of ZCN7/ZCN8 histone modification profiles in immature leaves of nonflowering id1 mutants and teosinte grown under floral inhibitory photoperiods reveals that both id1 floral inductive activity and SD-mediated induction result in histone modification patterns that are compatible with the formation of transcriptionally competent chromatin environments. Specific histone modifications are maintained during leaf development and may represent a chromatin signature that favors the production of processed ZCN7/ZCN8 messenger RNA in florigen-producing mature leaf. However, whereas id1 function promotes histone H3 hyperacetylation, SD induction is associated with increased histone H3 dimethylation and trimethylation at lysine-4. In addition, id1 and SD differently affect the production of ZCN7/ZCN8 antisense transcript. These observations suggest that distinct mechanisms distinguish florigen regulation in response to autonomous and photoperiod pathways. Finally, the identical expression and histone modification profiles of ZCN7 and ZCN8 in response to floral induction suggest that ZCN7 may represent a second maize florigen.

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The Histone Methyltransferase SDG724 Mediates H3K36me2/3 Deposition at MADS50 and RFT1 and Promotes Flowering in Rice

Cited by 107 publications

References 67 publications

A methyltransferase required for proper timing of the vernalization response in Arabidopsis

A methyltransferase required for proper timing of the vernalization response in Arabidopsis

SIP1 participates in regulation of flowering time in rice by recruiting OsTrx1 to Ehd1

Florigen-Encoding Genes of Day-Neutral and Photoperiod-Sensitive Maize Are Regulated by Different Chromatin Modifications at the Floral Transition

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