The histone lysine demethylase KDM5C fine-tunes gene expression to regulate dendritic cell heterogeneity and function
Hannah Guak,
Matthew J Weiland,
Alexandra R VanderArk
et al.
Abstract:The functional and phenotypic heterogeneity of dendritic cells (DCs) plays a crucial role in facilitating the development of diverse immune responses that are essential for providing host protection. We found that KDM5C, a histone lysine demethylase of the KDM5 family regulates several aspects of conventional DC (cDC) and plasmacytoid DC (pDC) population heterogeneity and function. Using mice conditionally deficient in KDM5C in DCs, we found that loss of KDM5C results in an increase in Ly6C- pDCs compared to L… Show more
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