“…Several deubiquitinases, such as USP1, USP3, USP16, and A20, are reported to be essential for proper HSC functions (Gu et al., 2016, Lancini et al., 2014, Nagamachi et al., 2014, Nakagawa et al., 2015, Parmar et al., 2010). For example, a lack of A20 in mice leads to defective HSC quiescence and reduced HSC numbers caused by enhanced NF-κB activation (Nagamachi et al., 2014, Nakagawa et al., 2015).…”