2015
DOI: 10.1074/jbc.m115.662650
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The Histone Demethylase UTX Promotes Brown Adipocyte Thermogenic Program Via Coordinated Regulation of H3K27 Demethylation and Acetylation

Abstract: Background: Brown fat functions to dissipate energy through adaptive thermogenesis. Results: The histone demethylase UTX positively regulates brown fat thermogenic program. Conclusion: UTX is a key determinant of brown fat gene expression. Significance: UTX may serve as a novel therapeutic target for enhancing brown fat function in the treatment of obesity.

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Cited by 71 publications
(69 citation statements)
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“…The expression of Brachyury was differentially induced in Utx -deficient adipocytes depending on the clones (Fig 3D). Recently, Utx has been reported to promote the expressions of genes responsible for thermogenesis in brown adipose tissue [24,25]. In our experiment, Utx deficiency did not affect the expression of Prdm16 , Pgc1 alpha , or Ucp1 , which are critical for thermogenesis in brown adipose tissue (Fig 3E).…”
Section: Resultssupporting
confidence: 53%
“…The expression of Brachyury was differentially induced in Utx -deficient adipocytes depending on the clones (Fig 3D). Recently, Utx has been reported to promote the expressions of genes responsible for thermogenesis in brown adipose tissue [24,25]. In our experiment, Utx deficiency did not affect the expression of Prdm16 , Pgc1 alpha , or Ucp1 , which are critical for thermogenesis in brown adipose tissue (Fig 3E).…”
Section: Resultssupporting
confidence: 53%
“…In diabetic mice, we also detected subtle and variable shifts in dysglycemia with GSK-J4 treatment, including a marginal decrease in blood glucose but an increase in glycated hemoglobin levels. Although the metabolic effects of Jmjd3 and UTX are mostly unknown, UTX upregulation was recently shown to promote the browning of adipose tissue (43), and thus its inhibition could theoretically impair energy expenditure.…”
Section: Discussionmentioning
confidence: 99%
“…Brown adipocyte differentiation is associated with increased expression of Jmjd3 (a H3K27me3 demethylase), ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX, demethylating H3K27me2–3), and lysine-specific histone demethylase 1 (LSD1, demethylating both H3K4me1–3 and H3K9me1–3) (235, 267, 359). Jmjd3 and UTX demethylate H3K27me3, a repressive epigenetic mark, at the promoters of UCP1 and other brown adipocyte-selective genes, thereby upregulating these genes (235, 359). Cold exposure or β3 agonist stimulation increase LSD1 expression in iWAT (71).…”
Section: Genetic and Epigenetic Regulation Of Brown And Beige Fat Thementioning
confidence: 99%