The histone chaperone SPT2 regulates chromatin structure and function in Metazoa
Giulia Saredi,
Francesco N. Carelli,
Stéphane G. M. Rolland
et al.
Abstract:Histone chaperones control nucleosome density and chromatin structure. In yeast, the H3–H4 chaperone Spt2 controls histone deposition at active genes but its roles in metazoan chromatin structure and organismal physiology are not known. Here we identify the Caenorhabditis elegans ortholog of SPT2 (CeSPT-2) and show that its ability to bind histones H3–H4 is important for germline development and transgenerational epigenetic gene silencing, and that spt-2 null mutants display signatures of a global stress respo… Show more
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