The Histological Effects of Ozone Therapy on Sciatic Nerve Crush Injury in Rats

Somay, Hakan; Emon, Selin Tural; Uslu, Serap; Orakdogen, Metin; Meric, Zeynep Cingu; İnce, Ümit; Hakan, Tayfun

doi:10.1016/j.wneu.2017.05.161

Cited by 19 publications

(14 citation statements)

References 26 publications

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“…Ozbay et al found less vascular congestion and macrovacuolation in the ozone group. Similarly, Somay H et al found less vacuolization, vascular congestion, edema, hemorrhage and fibrosis after ozone therapy [6,21]. In the present study the characteristics of sciatic nerve specimens in the untreated group were similar to those of the treated group (Figure 4.g) except for an increased abundance of schwann cells and cytoplasmic organelles in the treated group.…”

Section: Medical Ozone Therapy Of Sciatic Nerve Cut Injurysupporting

confidence: 82%

“…According to Vogelaar et al [24], sensory and motor functions were improved at the 3 rd postoperative week and the SFI and withdrawal reflex were also improved on the 30 th day after surgery [24]. Other studies on ozone therapy have found effective anti-inflammatory properties and reduced inflammation in rats [6,21,25]. In the early post-traumatic period, the number of Schwann cells increases rapidly, then decreases slowly.…”

Section: Medical Ozone Therapy Of Sciatic Nerve Cut Injurymentioning

confidence: 95%

“…Gupta and Steward reported an increase in the number of schwann cells in a chronic sciatic nerve compression model [26]. In contrast, Somay et al indicated a decrease in the number of schwann cells in their sciatic nerve model [21]. In the present study we observed an increased number of schwann cells, cytoplasmic organelles and M axons in nerve cut injury after ozone therapy, and SFI values and pinch tests were improved at postoperative 4 th week in the ozone group (p<0.05) compared to group 3 (postoperative 8 th week) (p<0.05).…”

Section: Medical Ozone Therapy Of Sciatic Nerve Cut Injurymentioning

confidence: 98%

“…Travagli et al [22], also reported that ozone increased the total antioxidant status. Somay H. [21] et al reported that ozone therapy increased blood circulation and oxygenation by releasing growth factors and cytokines and reducing chronic oxidative stress, and that it can stimulate adaptation of oxidative stress and protects against cellular damage caused by FR [21]. Ozone treatment plays an important role in the peripheral nerve injury regeneration process.…”

Section: Medical Ozone Therapy Of Sciatic Nerve Cut Injurymentioning

confidence: 99%

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Neuroprotective Effects of Ozone Therapy After Sciatic Nerve Cut Injury

et al. 2018

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A number of antioxidants have been used to treat peripheral nerve injury. However, there are few definitive experimental studies of ozone therapy for peripheral nerve cut injury. We aimed to examine the effects of mild level ozone therapy on sciatic nerve regeneration. One hundred adult male Wistar albino rats were randomly divided into four groups: group 1 (n=20) no cut injury or therapy; group 2 (n=20) sham; group 3 (n=30) nerve cut injury, no therapy; group 4 (n=30) nerve cut injury and ozone therapy. Sciatic functional index (SFI) and withdrawal reflex (WDR) were measured for all groups before nerve cut, at postoperative day 1, and at weeks 2, 4, 6 and 8. More myelinated (M) nerve fibers were observed after nerve cut injury in the ozone-therapy group. Significant differences were seen in plasma SOD (superoxide dismutase), CAT (catalase) and GPx (glutathione peroxidase) activities (p<0.05), and significant functional improvement was observed at postoperative weeks 2 and 4 (p<0.05) after ozone treatment. This is the first study conducted for the purpose of examining the effects of ozone therapy on sciatic nerve cut injury.

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Section: Medical Ozone Therapy Of Sciatic Nerve Cut Injurysupporting

confidence: 82%

Section: Medical Ozone Therapy Of Sciatic Nerve Cut Injurymentioning

confidence: 95%

Section: Medical Ozone Therapy Of Sciatic Nerve Cut Injurymentioning

confidence: 98%

Section: Medical Ozone Therapy Of Sciatic Nerve Cut Injurymentioning

confidence: 99%

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Neuroprotective Effects of Ozone Therapy After Sciatic Nerve Cut Injury

et al. 2018

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“…Additionally, inflammation of the central and peripheral nervous system helps to cause and sustain chronic neuropathic pain [1]. Issues related to crushing injuries include increased endoneurial edema, free oxygen radicals, inflammatory reactions, de-and remyelination, axonolysis, regeneration, and degeneration [2][3][4]. Inflammatory mediators such as prostaglandins, histamines, cytokines, chemokines, and growth factors are involved in nerve regeneration and degeneration that is associated with neuropathic pain [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive and Anti-Inflammatory Effects of Nypa fruticans Wurmb by Suppressing TRPV1 in the Sciatic Neuropathies

Kang

Hyun

2020

Nutrients

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Neuropathic pain is generally characterized by sensory abnormalities such as sensory disorders, hyperalgesia, and allodynia. Recent studies have reported that TRPV1 activation is essential for establishing of inflammation in the neuropathy pain models, showing that the expression of this receptor is increased, and contributing to enhanced thermal sensitivity. Nypa fruticans Wurmb (NF), which was used as a folk remedy, is a plant that is gaining attention due to its various effects. In this study, we investigated the antinociceptive and anti-inflammatory effects of NFE (Nypa fruticans Wurmb extracts) by controlling the neurological function of TRPV1. In sciatic crush injury rat models, a significant level of antinociceptive effect was observed in the thermal hyperalgesia test in which NF extracts (NFE 500 mg/kg) were orally administered, daily. Protein quantification of the sciatic nerve and the of the L4–L6 spinal cord showed a decrease of the TRPV1 expression, the inflammatory expression factor, COX2, and proinflammatory factors in the NFE treated groups. Our results indicate that NFE affects antinociceptive and anti-inflammatory by controlling TRPV1 in sciatic neuropathic pain models.

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