The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies

Adams, Leon A.; Sanderson, Schuyler O.; Lindor, Keith D.; Angulo, Paul

doi:10.1016/j.jhep.2004.09.012

Cited by 814 publications

(645 citation statements)

References 33 publications

(37 reference statements)

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“…So with this we concluded that maximum patients are of middle age ie from age 31-60 years comprising 76% of total patients and mean age was found 47.24 ± 12.22. Similar findings was also observed by Adams LA et al 7 and Agrawal R et al 8 who reported mean age 45.0 ± 11.0 and 42.70 ± 10.09 respectively. various biochemical parameters of the patients were also compared across the Gender where it was found variable like triglycerides, ALT, AST were approximately same across the Gender without any significance with P values of (0.533,0.342,0.167) respectively but cholesterol levels across the Gender was significant (P=0.014).…”

Section: Discussionsupporting

confidence: 89%

To Study the Biochemical Parameters in Non-Alcoholic Fatty Liver Disease Patients

Warkade¹

2018

jmscr

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Section: Discussionsupporting

confidence: 89%

To Study the Biochemical Parameters in Non-Alcoholic Fatty Liver Disease Patients

Warkade¹

2018

jmscr

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“…Therefore, a CT L-S of less than 1 HU could be used as a conservative criterion for diagnosing hepatic steatosis with nonenhanced CT more consistently. diagnosis of hepatic steatosis and is widely generalizable, the low sensitivity of this approach considerably limits the capability of nonenhanced CT in the detection of hepatic steatosisparticularly nonalcoholic fatty liver disease and nonalcoholic steatohepatitisas patients with these conditions frequently have a mild degree of hepatic steatosis (25)(26)(27). Although the CT fi ndings of hepatic steatosis should not be neglected when interpreting CT data, it may be inappropriate to perform nonenhanced CT to diagnose mild hepatic steatosis.…”

Section: Discussionmentioning

confidence: 99%

Biopsy-proven Nonsteatotic Liver in Adults: Estimation of Reference Range for Difference in Attenuation between the Liver and the Spleen at Nonenhanced CT

et al. 2011

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Purpose:To establish the reference range for hepatic attenuation minus splenic attenuation difference (CT L 2 S ) values on nonenhanced computed tomographic (CT) images obtained in adults with a biopsy-proved nonsteatotic liver and determine the CT L 2 S criterion for diagnosing hepatic steatosis. Materials and Methods:This retrospective study was institutional review board approved, and all subjects had provided written informed consent. The CT L 2 S was measured in 315 liver donor candidates (207 men, 108 women; mean age, 31.5 years 6 10.1 [standard deviation]) who underwent nonenhanced CT of the liver and subsequent ultrasonographically guided liver biopsy on the same day. Nonenhanced liver CT was performed with a 16-section multidetector scanner in 154 individuals and with a 64-section multidetector scanner in 161 individuals. Biopsy specimens were analyzed for degree of hepatic steatosis and iron deposition. The CT L 2 S reference range was determined according to Clinical and Laboratory Standards Institute guideline C28-A3 in individuals with a histologically proved nonsteatotic liver. The sensitivity of nonenhanced CT for the diagnosis of 5% or greater and 30% or greater hepatic steatosis with use of the lower limit of the reference range as the diagnostic cutoff was determined. The effects of subject age and sex, CT scanner type, and hepatic iron on the CT L 2 S were evaluated by using multiple linear regression analysis. Results:Ninety-six subjects (48 men, 48 women) were found to have a histologically proved nonsteatotic liver, with an estimated reference range for CT L 2 S values of 1-18 HU. With a CT L 2 S of less than 1 HU as the criterion for hepatic steatosis, the sensitivities of nonenhanced CT for 5% or greater and 30% or greater hepatic steatosis were 18.6% (29 of 156 subjects) and 67 % (26 of 39 subjects), respectively. Subject age had a signifi cant but negligible effect on CT L 2 S (0.076-HU increase per year of age, P = .009), subject sex and scanner type had no effects on CT L 2 S , and hepatic iron deposition signifi cantly increased the CT L 2 S (1.434-HU increase per increase in iron deposition grade, P = .011). Conclusion:The histologically proved reference range of CT L 2 S values for nonsteatotic livers was 1-18 HU. A CT L 2 S of less than 1 HU could be used as a conservative criterion for diagnosing hepatic steatosis with nonenhanced CT more consistently.q RSNA, 2011

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“…4,5 When paired biopsies are performed, 30% to 50% of NAFLD patients have histological progression with time. [6][7][8] Alanine aminotransferase (ALT) is an enzyme found abundantly in the cytosol of hepatocytes. 9 Serum ALT level is commonly used to reflect hepatic inflammation and injury in patients with chronic liver disease.…”

mentioning

confidence: 99%

Metabolic and histological features of non‐alcoholic fatty liver disease patients with different serum alanine aminotransferase levels

Wong

Tsang

et al. 2009

Aliment Pharmacol Ther

108

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The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies

Cited by 814 publications

References 33 publications

To Study the Biochemical Parameters in Non-Alcoholic Fatty Liver Disease Patients

To Study the Biochemical Parameters in Non-Alcoholic Fatty Liver Disease Patients

Biopsy-proven Nonsteatotic Liver in Adults: Estimation of Reference Range for Difference in Attenuation between the Liver and the Spleen at Nonenhanced CT

Metabolic and histological features of non‐alcoholic fatty liver disease patients with different serum alanine aminotransferase levels

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